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Oral composition containing crystalline cellulose surface-treated with water-soluble substance

A technology of crystalline cellulose and water-soluble substances, which is applied in the field of oral compositions, can solve the problems of compromising the stability of the composition and the feeling of use due to stringing, and achieve excellent feeling of use, low stringiness and high dispersibility Effect

Inactive Publication Date: 2009-10-21
SUNSTAR KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, low-viscosity compositions, especially components such as abrasives, precipitate and impair the stability of the composition, sink between the brushes when placed on a toothbrush, and cause stringiness, etc., which impair the feeling of use.

Method used

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  • Oral composition containing crystalline cellulose surface-treated with water-soluble substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0071] Example 2 Dispersibility of ingredients

[0072] Preparation of oral compositions

[0073] An oral composition (Example 2) using crystalline cellulose surface-treated with a water-soluble substance used in the present invention was prepared according to the formulation shown in Table 2 below, and the same raw materials and equivalent shape retention properties were used Oral composition using crystalline cellulose and a water-soluble substance as a monomer (Comparative Example 2).

[0074] [Table 2]

[0075] Composition Example 2 Comparative Example 2

Crystalline cellulose (carboxymethylcellulose sodium surface treatment, crystalline cellulose: carboxy 4 -

Sodium methylcellulose=89:11 (weight ratio))

Crystalline Cellulose - 3.56

Sodium carboxymethylcellulose - 2.04

Silica 10 10

Glycerin 30 30

Sorbitol solution 20 20

Sodium lauryl sulfate 1 1

Hexadecyl pyridinium chloride 0.1 0.1

Tranexamic acid 0.1 0.1

Dipotassium...

Embodiment 3    Embodiment 4    comparative example 3

[0098] 5 seconds 2 2 1

[0099] 15 seconds 3 8 1

[0100] 30 seconds 6 44 2

[0101] 60 seconds 33 60 21

[0102] 120 seconds 90 70 55

[0103] 180 seconds 98 80 61

[0104] As is clear from the results in Table 5, the dispersibility of the oral compositions of Examples 3 and 4 improved after shaking for 5 seconds, and most of them dispersed after 3 minutes. On the other hand, the dispersibility of the oral composition of Comparative Example 3 was low, and only 61% was dispersed even after 3 minutes when the oral composition of Example 3 was almost completely dispersed.

[0105] Dispersion test 2

[0106] In order to compare the difference in dispersibility of the shorter shaking time, except that the number of revolutions of the shaking machine was changed to 320 times / min, the dispersion of each active ingredient of the oral composition of Example 2 and Comparative Example 2 was studied under the same conditions. sex. The results are shown in Table 6.

[0107] [Table...

Embodiment 5

[0112] toothpaste

[0113] Ingredient name Compounding amount (weight %)

[0114] Crystalline cellulose (sodium carboxymethyl cellulose surface treatment,

[0115] Crystalline cellulose: sodium carboxymethyl cellulose=85:15) 3.0

[0116] Hydroxyethyl Cellulose 1.0

[0117] Lauryl Glucoside 3.0

[0118] Decyl Glucoside 1.0

[0119] Calcium hydrogen phosphate 30.0

[0120] Hexadecyl pyridinium chloride 0.1

[0121] Pyridoxine hydrochloride 0.1

[0122] Sodium monofluorophosphate 0.72

[0123] Spice 1.0

[0124] Sodium saccharin 0.1

[0125] Titanium oxide 0.3

[0126] Propylene Glycol 3.0

[0127] Concentrated Glycerin 20.0

[0128] Pure water balance

[0129] Total 100.0

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Abstract

The invention relates to an oral composition, particularly a dentifrice composition, which contains crystalline cellulose surface-treated with a water-soluble substance and is excellent in shape retention and dispersibility in the oral cavity. The oral composition of the invention can be favorably placed on a brush such as a toothbrush because it has low spinnability, and also enables blended components to immediately disperse throughout the oral cavity when it is used in the oral cavity, therefore, an active ingredient can be dispersed throughout the oral cavity for longer time, and a favorable feeling of use can be provided.

Description

technical field [0001] The present invention relates to oral compositions. Specifically, it relates to an oral composition, particularly a dentifrice composition, which contains crystalline cellulose surface-treated with a water-soluble substance and is excellent in shape retention and oral dispersibility. Background technique [0002] Tooth-cleaning compositions are required not only to function as auxiliary cleaning agents for toothbrushes, but also as oral health preparations that actively prevent / treat oral diseases, prevent bad breath, whiten, etc., by incorporating ingredients that have various functions. function. However, even if such components with various functions are combined, if they are not quickly dispersed throughout the oral cavity when applied to the oral cavity, their functions cannot be fully exerted and the purpose cannot be achieved. [0003] Generally, the dosage form of the composition suitable for dispersing such ingredients throughout the oral ca...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61Q11/00
CPCA61K8/731A61Q11/00A61K8/73
Inventor 中尾彰长谷川谨崇
Owner SUNSTAR KK
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