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Quality control method of fresh fleece flower root and prepared fleece flower root

A quality control method and technology for preparing Polygonum multiflorum, which can be used in measuring devices, pharmaceutical formulations, medical preparations containing active ingredients, etc., which can solve the problem that traditional Chinese medicine Polygonum multiflorum cannot meet production and utilization, cannot accurately reflect the efficacy of Polygonum multiflorum, and test results are inconsistent. Objective and accurate problems, to achieve the effect of reducing the possibility of human processing, strong ability to express traditional Chinese medicine information, and overcoming limitations

Inactive Publication Date: 2009-10-14
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The identification of appearance traits (including microscopic identification) in this quality control method has strong subjective factors, the test results are not objective and accurate, and the error is large
Moreover, the efficacy of Polygonum multiflorum is not only related to a single component, but is determined by multiple active components. The determination method of single component content has limitations and cannot accurately reflect the efficacy of Polygonum multiflorum.
Therefore, the existing quality control methods of the traditional Chinese medicine Polygonum multiflorum can not meet the needs of production and utilization

Method used

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  • Quality control method of fresh fleece flower root and prepared fleece flower root
  • Quality control method of fresh fleece flower root and prepared fleece flower root
  • Quality control method of fresh fleece flower root and prepared fleece flower root

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specific Embodiment approach

[0051] A specific embodiment of the present invention is: a quality control method for raw and prepared Polygonum multiflorum, which consists of the following steps:

[0052] A. Fingerprint comparison

[0053] A1, establish the standard fingerprint of Radix Polygoni Multiflori

[0054] The raw Polygonum multiflorum standard medicinal material in this example is Polygonum multiflorum directly collected from Mount Emei in Sichuan.

[0055] Take 0.2 g of the standard medicinal material powder of Radix Polygoni Multiflori, dissolve it in 8ml of acetone, filter it after ultrasonic treatment for 0.5 hours, take the filtrate, repeat three times (including this time), combine the filtrate, add acetone, and dilute to 25ml to obtain the standard medicinal material Accurately measure 5ml of acetone solution, and after the acetone evaporates to dryness, dry powder is obtained, and the dry powder is dissolved in 2ml of methanol to obtain a methanol solution, and the methanol solution is f...

Embodiment 2

[0087] This example is basically the same as Example 1, except that the standard medicinal material of Radix Polygoni Multiflori is replaced with the standard medicinal material of Radix Polygoni Multiflori, and the medicinal material of Radix Polygonum multiflorum to be tested is replaced with the medicinal material of Radix Polygoni Multiflori to be tested. The standard medicinal material for producing Radix Polygoni Multiflori is prepared from Radix Polygoni Multiflori Radix Polygonum multiflorum produced in Mount Emei, Sichuan by steaming or black bean processing; in this example, a specific medicinal material to be tested is the Polygonum Polygonum multiflorum medicinal material purchased in Deqing, Guangdong.

[0088] image 3 It is the standard fingerprint spectrum of Radix Polygoni Multiflori Radix Radix Polygoni Multiflori, which is measured by the method of this example. image 3 It can be seen that there are 6 characteristic peaks with high peaks in the standard fin...

Embodiment 3

[0094] This example is basically the same as Example 1, except that in the comparison of fingerprints in step A, the powder of the standard medicinal material of Radix Polygoni Multiflori is 0.1 gram, and the time of each ultrasonic treatment is 1 hour; The precisely weighed 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucopyranoside reference substance was 3.2 mg, and the precisely weighed emodin in step C was 2.8 mg.

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Abstract

The invention relates to a quality control method of fresh fleece flower root and prepared fleece flower root which comprises the steps as follows: A. standard crude drug powder of fresh fleece flower root or prepared fleece flower root is weighed and dissolved in acetone; the solution undergoes ultrasonic treatment and is then filtered, brought to constant volume and evaporated to dry; obtained dry powder is dissolved in methyl alcohol and the methyl alcohol solution is filtered by Millipore, thereby obtaining standard crude drug solution; fingerprint spectrum of the standard crude drug is then worked out by high performance liquid chromatography; the same method is then employed to establish fingerprint spectrum awaiting measurement of fresh fleece flower root or prepared fleece flower root to be measured; similarity between the fingerprint spectrum awaiting measurement and the standard fingerprint spectrum are then used for deciding whether the crude drug to be measured is qualified. B. contents of two index components, including 2, 3, 4', 5-tetrahydroxystilbene-2-O-beta-D-glucopyranoside and rheum emodin, are measured by high performance liquid chromatography. The quality control method has various judging evidences, thereby not only realizing qualitative detection of major chemical compositions of fresh and prepared fleece flower root, but also measuring contents of the two major components. The quality control method has reliable and precise measurement result, thereby reducing possibility of quality pass rate affected by manual treatment.

Description

technical field [0001] The invention relates to a quality control method of traditional Chinese medicine, in particular to a quality control method for raw and prepared Polygonum multiflorum; Background technique [0002] Polygonum multiflorum was first recorded in "Rihuazi Materia Medica". It is the dry root tuber of Polygonum multiflorum Thunb, a plant of Polygonum multiflorum Thunb. It is mainly produced in Henan, Shandong, Hubei, Sichuan, Jiangsu, Guangxi and other places. It is mostly wild and also cultivated. The well-known traditional Chinese medicine for raw and cooked different treatments can be divided into raw and prepared Polygonum multiflorum; Raw Polygonum multiflorum is flat in nature, sweet and bitter; Guixin, liver, and large intestine meridian; Polygonum multiflorum prepared is slightly warm in nature, sweet in taste, astringent, and returns to liver, Kidney meridian; Raw Polygonum multiflorum cuts malaria and detoxifies, moistens the intestines and relieve...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61P1/10A61P1/14A61P3/06G01N30/86A61K125/00
Inventor 吴晓青童妍蒋合众
Owner SOUTHWEST JIAOTONG UNIV
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