Liver, spleen specific positive magnetic nuclear resonance contrast agent and method of preparing the same

Abstract

The present invention disclose a specific positive magnetic nuclear resonance contrast agent and method of preparing the same, the contrast agent is applying gadopentetate dimeglumine (Gd-DTPA) coating or scion grafting to 1-100 nm hydroxylapatite [Ca [10](PO [4][6](OH)[2], short as HA) particles, to obtain composite granule smaller than 1000 nm, modified by proserum, polyethylene imine (PEI), polyethyleneglycol (PEG) to get dispersion stability colloid solution. Comparing with the present technology the positive magnetic nuclear resonance contrast agent of the invention is provided with low toxicity, high stability, good biocompatibility, high sensibility, high relaxation capability and liver, spleen specificity. The contrast agent colloid solution can be used for enhancing contrast imaging of human body or non-human body liver or spleen.

Description

A liver-spleen-specific positive nuclear magnetic resonance contrast agent and preparation method thereof technical field The invention relates to the field of medical materials, in particular to a specific positive nuclear magnetic resonance contrast agent for liver and spleen and its preparation method technical background Tumor is one of the major diseases affecting human health in today's society. A research report published by the World Health Organization shows that the global cancer situation will become increasingly serious, the number of new patients will increase from the current 10 million per year to 15 million in the next 20 years, and the number of deaths from cancer will also increase from 6 million to 10 million per year , cancer has become the first cause of death, and the incidence of liver cancer ranks third among cancers. Every year in China, about 350,000 patients die of liver cancer caused by hepatitis B and cirrhosis, and the trend is increasing year...

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Problems solved by technology

Superparamagnetic iron oxide contrast agents (such as iron oxide nanoparticles), because the magnetic nanoparticles have high toxicity to the human body and poor biocompatibility, people use polymers with certain biocompatibility or human serum albumin Coated to reduce its toxicity to the human body, but these contrast agents are not ideally compatible with human blood

At present, the MRI contrast agents used in domestic hospitals are basically non-specific contrast agents (such as gadolinium (Gd) chelate). Due to its non-specific shortcomings, similar signal changes can be seen in various tissues of patients after injection, resulting in image Poor contrast ratio greatly affects the diagnostic accuracy of MRI

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