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Applications of dendrobium nobile lindl alkaloids in medicines prepared for treating senile dementia and product thereof

A technology of Dendrobium nobile and biological total alkaloids, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as unclear mechanism of action

Active Publication Date: 2009-09-23
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that Dendrobium extract can significantly inhibit the secretion of IL-10, TNF-α, iNOS and IL-8 from mouse peritoneal macrophages induced by bacterial lipopolysaccharide (LPS), but its mechanism of action is still unclear and needs further investigation Research
At present, there is no research report on the effect of Dendrobium nobile extract on senile dementia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1 of the present invention: the extraction of total alkaloids of Dendrobium nobile:

[0055] Take the medicinal material of Dendrobium nobile, crush it into coarse powder, add 95% ethanol to reflux and extract 3 times, recover the ethanol until it has no alcohol smell, adjust the pH to 3-4 with hydrochloric acid, filter, and adjust the pH of the filtrate to 10 with 10% ammonia water, Then extract with appropriate amount of chloroform for 7-8 times, collect the chloroform layer, recycle the chloroform, and dry to obtain the total alkaloids of Dendrobium nobile; wherein the content of lipophilic total alkaloids is 68.3%.

Embodiment 2

[0056] Embodiment 2 of the present invention: the extraction of total alkaloids of Dendrobium nobile:

[0057] Take the medicinal material of Dendrobium nobile, crush it into coarse powder, add ethanol to extract 3 times, recover the ethanol until it has no alcohol smell, adjust the pH to 3-4 with hydrochloric acid, filter, adjust the pH of the filtrate to 10 with sodium hydroxide solution, and then use an appropriate amount of Extract 5-6 times with chloroform, collect the chloroform layer, recycle the chloroform, and dry to obtain the total alkaloids of Dendrobium nobile, wherein the content of lipophilic total alkaloids is 61.9%.

Embodiment 3

[0058] Embodiment 3 of the present invention: the application of total alkaloids of Dendrobium nobile:

[0059] Get 50-2000 mg of Dendrobium nobile total alkaloid extract, 0.1-0.40 mg of magnesium stearate, 4-12 mg of sodium carboxymethyl starch, and 50-100 mg of microcrystalline cellulose obtained in Example 1, and extract The product is mixed with sodium carboxymethyl starch and microcrystalline cellulose, sieved, mixed evenly, added an appropriate amount of water or ethanol to granulate, after drying, granulated, added magnesium stearate, and then pressed the granules with a punching device into Tablets, that is, tablets for treating senile dementia. The tablet is taken orally, 3 times a day, 1-3 tablets each time.

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Abstract

The invention discloses applications of dendrobium nobile lindl alkaloids (DNLA) in medicines prepared for treating senile dementia and a product thereof. The DNLA is lipophilic total alkaloids composition which is extracted from the dendrobium nobile lindl. Compared with the prior art, the invention makes clear the pharmacological action and mechanism action of the DNLA for treating senile dementia by studying the action of the DNLA for protecting nerve cells and cerebral ischemia model and the influence of the DNLA on the capacity of learning and memory of rats, and provides pharmacological basis for the development and applications of the dendrobium nobile lindl medical material.

Description

Technical field: [0001] The invention relates to the application and product of total biological alkaloids of Dendrobium nobile in the preparation of medicines for treating senile dementia, and belongs to the technical field of traditional Chinese medicines. Background technique: [0002] Alzheimer's disease (AD) is an aging-related disease and the main cause of dementia in the elderly over 65 years old. With the emergence of my country's population aging problem, AD has become an important issue of family burden and social medical insurance. The clinical manifestations of AD are progressive mental decline, mental and motor disorders, and the main pathological features are senile plaques (SP), neurofibrillary tangles (NFT), vascular amyloidosis, neuronal degeneration and loss. AD is a heterogeneous disease with multiple causes, and the exact etiology and pathogenesis are still unclear. Existing studies have shown that its pathogenesis may involve gene defects, central neur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P25/28
Inventor 石京山
Owner ZUNYI MEDICAL UNIVERSITY
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