A Xuesaitong pharmaceutical composition and its preparation method, preparation and application

A technology of Xuesaitong and its composition, which is applied in the field of Xuesaitong pharmaceutical composition and its preparation, can solve the problems of unfixed medicinal ingredients and composition, adverse reactions, unclearness, etc., and achieve reduction of myocardial infarction size and cardiac function. Impairment improvement, the effect of improving heart function indicators

Active Publication Date: 2021-06-22
KPC PHARM INC
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  • Description
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AI Technical Summary

Problems solved by technology

[0003] Panax notoginseng saponins (PNS) is a general term for a series of saponins and their aglycon components extracted from the traditional Chinese medicine Panax notoginseng. figure out
However, the raw materials of Panax notoginseng saponins (PNS) from different manufacturers are currently on the market. Due to the different origins of the medicinal materials Panax notoginseng used for extraction of Panax notoginseng saponins, different parts of the drug, different harvesting time and years, as well as extraction methods and process conditions Different, the chemical composition of the obtained Panax notoginseng saponins (PNS) is not the same, even if it is different batches of Panax notoginseng saponins (PNS) produced by the same manufacturer, its chemical composition and the composition and content of Panax notoginseng saponins are also very different
It is precisely because of the above reasons that the medicinal ingredients and composition of Xuesaitong products on the market are not fixed and unclear, and the medicinal ingredients and composition ratios of products from different manufacturers or different batches vary greatly, which seriously affects the clinical efficacy of the products. and cause a series of adverse reactions and safety problems, therefore, it is urgent for scientific researchers to study and solve

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  • A Xuesaitong pharmaceutical composition and its preparation method, preparation and application
  • A Xuesaitong pharmaceutical composition and its preparation method, preparation and application
  • A Xuesaitong pharmaceutical composition and its preparation method, preparation and application

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preparation example Construction

[0181] The preparation method of Xuesaitong pharmaceutical composition of the present invention, comprises the steps:

[0182] Step 1): Weigh notoginsenoside R1, place it in an ethanol solvent, stir and dissolve to obtain solution A;

[0183] Step 2): Weigh ginsenoside Rb2, ginsenoside Rb1, ginsenoside Rg1 and ginsenoside Rc, stir and dissolve in distilled water, heat to 50-70°C, add solution A while stirring, add activated carbon for needles, heat up and boil for 30 -50 minutes, let stand to cool to room temperature, filter out activated carbon;

[0184] Step 3): Put the above filtrate in a vacuum freeze dryer, cool down to -40~-30°C, pre-freeze for 3~5 hours, then control the temperature at -25~-20°C, pressure 10~20Pa, sublimation and dry for 3~ 5 hours, and then control the temperature at 30-50°C, pressure at 1-10Pa, and analyze and dry for 4-6 hours to obtain it.

[0185] In step 1), the mass ratio of notoginseng saponin R1 to ethanol solvent is 0.05-5:100, and the volum...

Embodiment 11

[0251]The preparation of embodiment 1 1# pharmaceutical composition

[0252] Raw material composition:

[0253] Ginsenoside Rb2 54.6 g

[0254] Ginsenoside Rb1 21.1 g

[0255] Ginsenoside Rg1 11.3 g

[0256] Ginsenoside Rc 8.5 g

[0257] Notoginsenoside R1 4.5g

[0258] Total 100g

[0259] Preparation:

[0260] 1) Weigh 4.5 g of notoginseng saponin R1, place it in 100 g of ethanol solvent with a concentration of 50% by volume, stir and dissolve to obtain solution A;

[0261] 2) Weigh 54.6 g of ginsenoside Rb2, 21.1 g of ginsenoside Rb1, 11.3 g of ginsenoside Rg1 and 8.5 g of ginsenoside Rc, stir and dissolve in 900 g of distilled water, heat to 50-70°C, add solution A while stirring, Add 2.0g of activated carbon for needles, heat up and boil for 30-50 minutes, let it stand to cool to room temperature, filter out the activated carbon;

[0262] 3) Put the above filtrate in a vacuum freeze dryer, cool down to -40~-30℃ at a cooling rate of 5℃ / h, pre-freeze for 3~5 hours, ...

Embodiment 2

[0263] The preparation of embodiment 2 2# pharmaceutical composition

[0264] Raw material composition:

[0265] Ginsenoside Rb2 20.5 g

[0266] Ginsenoside Rb1 47.8 g

[0267] Ginsenoside Rg1 23.4 g

[0268] Ginsenoside Rc 6.7 g

[0269] Notoginsenoside R1 1.6 g

[0270] Total 100g

[0271] Preparation:

[0272] 1) Weigh 1.6 g of notoginseng saponin R1, place it in 100 g of ethanol solvent with a concentration of 80% by volume, stir and dissolve to obtain solution A;

[0273] 2) Weigh 20.5 g of ginsenoside Rb2, 47.8 g of ginsenoside Rb1, 23.4 g of ginsenoside Rg1 and 6.7 g of ginsenoside Rc, stir and dissolve in 950 g of distilled water, heat to 50-70°C, add solution A while stirring, Add 1.0g of activated carbon for needles, heat up and boil for 30-50 minutes, let it stand and cool to room temperature, and filter out the activated carbon;

[0274] 3) Put the above filtrate in a vacuum freeze dryer, cool down to -40~-30℃ at a cooling rate of 15℃ / h, pre-freeze for 3~...

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Abstract

The invention discloses a Xuesaitong pharmaceutical composition, its preparation method, preparation and application. The Xuesaitong pharmaceutical composition includes the following pharmaceutical components in mass percentage: 0.001-99.996% of ginsenoside Rb2, 0.001-99.996% of ginsenoside Rb1, 0.001-99.996% of ginsenoside Rg1, 0.001-99.996% of ginsenoside Rc and Notoginsenoside R1 0.001~99.996%. The pharmaceutical composition of the present invention and its preparation are effective for myocardial infarction, cerebral apoplexy, cerebral infarction, cerebral hemiplegia and other ischemic cardiovascular and cerebrovascular diseases, as well as retinopathy or optic nerve damage caused by ischemic cardiovascular and cerebrovascular diseases, diabetes and other reasons. Significant curative effect, has broad application prospects. Compared with the prior art and products, the Xuesaitong medicinal composition and its preparations of the present invention have better curative effect and higher safety, and can better meet the requirements of clinical medication. The preparation method provided by the invention has simple process, mild conditions, convenient operation, stable and controllable quality, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to a Xuesaitong pharmaceutical composition and a preparation method, preparation and application thereof. Background technique [0002] Panax Notoginseng (Burk) F. Panax Notoginseng (Burk) The dried roots and rhizomes of H Chen, also known as Panax notoginseng and Tianqi, are precious traditional Chinese medicines for the treatment of cardiovascular and cerebrovascular diseases. According to "Yu Pu Yao Jie", Panax notoginseng can "heal the blood to stop bleeding, clear blood stasis, remove blood stasis and collect new blood. All postpartum, menstrual period, trauma, carbuncle, all blood stasis are broken; Metrorrhagia, knife wounds, arrow wounds, all new blood will stop." [0003] Panax notoginseng saponins (PNS) is a general term for a series of saponins and their aglycones extracted from the traditional Chinese medicine Panax notoginseng. Its components are diverse a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K9/48A61P9/00A61P9/10A61P25/02A61P27/02
CPCA61K9/4816A61K9/4825A61K31/704A61P9/00A61P9/10A61P25/02A61P27/02A61K2300/00
Inventor 周荣光赵加强顾静波文冰亭郭泽剑
Owner KPC PHARM INC
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