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Anti-collapsibility calcium phosphate cement, preparation method and application thereof

A calcium phosphate bone cement, anti-collapse technology, applied in medical science, prosthesis and other directions, can solve the problems of reducing the strength of the implant, delaying the curing time of calcium phosphate bone cement, and collapsing, etc., to expand the medical value and improve the anti-collision. The effect of improving the collapsing performance and anti-collision performance

Inactive Publication Date: 2009-09-09
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The primary purpose of the present invention is to overcome the deficiencies in the prior art of calcium phosphate bone cement that will collapse when soaked and washed by body fluids before self-curing and that the existing anti-collapse agent will delay the curing time of calcium phosphate bone cement and reduce the strength of the implant to provide an anti-collapse calcium phosphate bone cement

Method used

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  • Anti-collapsibility calcium phosphate cement, preparation method and application thereof
  • Anti-collapsibility calcium phosphate cement, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 10% by mass percentage of β-cyclodextrin and 90% of amorphous calcium phosphate-calcium hydrogen phosphate bone cement were evenly mixed. Then, mix the deionized water and the calcium phosphate bone cement containing β-cyclodextrin prepared in this example evenly according to the liquid-solid ratio of 0.4ml / g, and reconcile it into a paste, inject it into the affected part of the patient through the injection device, Perform clinical repair. The comparison of physical and chemical properties between the anti-collapse calcium phosphate bone cement containing β-cyclodextrin prepared in this example and ordinary calcium phosphate bone cement is shown in Table 1:

[0031] Table 1

[0032] liquid to solid ratio

ml / g

β-cyclodextrin

Anti-collapse system

number(%)

Anti-collapse

Room (min)

curing time

(min)

compressive strength

(MPa)

0.4

-

15

3.5

14

25

0.4

...

Embodiment 2

[0036] 2 mass percent carboxylated β-cyclodextrin ((2,6-di-O-carboxymethyl)-β-cyclodextrin) and 98% tetracalcium phosphate-calcium hydrogen phosphate bone cement were evenly mixed. Then mix the pH7.2 disodium hydrogen phosphate buffer solution with the anti-collapse calcium phosphate bone cement containing carboxylated β-cyclodextrin prepared in this example according to the liquid-solid ratio of 0.5ml / g, and mix them into a paste The drug is injected into the patient's diseased part through an injection device for clinical repair. The physical and chemical properties of the anti-collapse calcium phosphate bone cement containing carboxylated β-cyclodextrin prepared in this example and ordinary calcium phosphate bone cement are shown in Table 2:

[0037] Table 2

[0038] liquid to solid ratio

[0039] Compared with ordinary calcium phosphate bone cement, the anti-collapse calcium phosphate bone cement containing carboxylated β-cyclodextrin prepared in this example ha...

Embodiment 3

[0041] Mix 5% by mass of methylated β-cyclodextrin (2,6-dimethyl-β-cyclodextrin) with 95% of tetracalcium phosphate-β-tricalcium phosphate-calcium dihydrogen phosphate bone cement uniform. Then mix the pH7.0 sodium dihydrogen phosphate buffer solution with the anti-collapse calcium phosphate bone cement containing methylated β-cyclodextrin prepared in this example according to the liquid-solid ratio of 0.6ml / g, and mix them into a paste The shape is injected into the patient's diseased part through an injection device for clinical repair. The comparison of physical and chemical properties between the anti-collapse calcium phosphate bone cement containing methylated β-cyclodextrin prepared in this example and ordinary calcium phosphate bone cement is shown in Table 3:

[0042] table 3

[0043] liquid to solid ratio

[0044] Compared with ordinary calcium phosphate bone cement, the anti-collapse calcium phosphate bone cement containing methylated β-cyclodextrin prepa...

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Abstract

The invention belongs to the technical field of medical bone injury restoration materials, in particular discloses anti-collapsibility calcium phosphate cement, as well as a preparation method and the application thereof. The anti-collapsibility calcium phosphate cement is prepared by uniformly mixing 2-10 percent of beta-cyclodextrin or derivates thereof by mass percentage with 90-98 percent of common calcium phosphate cement by mass percentage. The invention successfully applies the beta-cyclodextrin or the derivates thereof to the common calcium phosphate cement for the first time, not only remarkably improves the anti-collapsibility performance of original calcium phosphate cement, but also keeps the original curing characteristics of the original calcium phosphate cement and improves the mechanical performance requirements thereof, effectively improves the success rate of operations, widens the application fields of the beta-cyclodextrin or the derivates thereof and enables the calcium phosphate cement to have wider application prospects.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing bone damage, and in particular relates to an anti-collapse calcium phosphate bone cement and its preparation method and application. Background technique [0002] Calcium phosphate bone cement is composed of powder mixed with one or more calcium phosphate salts and a solidification solution. When used, the two are blended in a certain proportion, and can be cured and plasticized at room temperature or in the environment of the human body. The reaction is finally converted into hydroxyapatite (HA), which can guide bone growth, be gradually absorbed by tissue and produce bone tissue regeneration effect, has good biocompatibility, and currently shows great clinical application in bone defect repair However, the material still has shortcomings, especially it is prone to collapse during implantation, which reduces the strength of the material after implantation, and in severe cases leads ...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/20A61L27/12
Inventor 叶建东于涛王迎军
Owner SOUTH CHINA UNIV OF TECH
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