Process for preparing slow and controlled micro pills

A preparation process and miniature technology, which can be used in medical preparations with non-active components, non-active components of polymer compounds, capsule delivery, etc. effect of release phenomenon, low equipment cost and high bioavailability

Inactive Publication Date: 2009-08-26
孙民富
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sustained and controlled release preparations prepared by the above method have the disadvantages of small capacity, difficult to control the release rate, complicated process, and high cost.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] A group of specific embodiments are provided below to further illustrate the method:

[0024] Example 1 Based on the total weight of 100g, 37% of PEG4000, 29% of PEG6000, 11% of stearic acid, 14% of glyceryl monostearate, and 10% of matrine. After heating and melting the matrix in a water bath, add the pulverized bitter The ginseng, stir well to make it evenly mixed, spray it into very fine mist liquid beads under the condition of 80 ℃ heat preservation, contact with 5 ℃ cold air in parallel and cool it in a very short time to get the finished product.

[0025] The obtained product has a 2-hour cumulative release percentage of 38-68%, a 6-hour cumulative release percentage of 65-85%, a 10-hour cumulative release percentage of 75-95%, and good roundness.

[0026] Example 2 Based on the total weight of 100g, PEG4000 50%, PEG6000 12%, stearic acid 6%, poloxamer 12%, matrine 20%, after heating and melting the matrix in a water bath, add the pulverized matrine , Stir fully ...

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PUM

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Abstract

The invention discloses a process for preparing slow and controlled micro dripping pills and belongs to the technical field of medicine production. The process is to prepare micro dripping pills by using a solid dispersion technology, hydrophilic and hydrophobic materials as a carrier and a spray or dripping method. The key points of the technical proposal of the invention include: a mixed carrier is adopted; the medicine exists in molecular, gel micro-crystal metastable state microparticle and other high energy states; a solid dispersion system with highly-dispersed multiple systems is formed; a centrifugal spray, pressure spray or dripping method is used for preparing the micro dripping pills; and the micro dripping pills can be tableted, or filled into capsules, or packaged with bottles, bags, bubble cap and the like. The invention relates to a method for preparing the slow and controlled micro dripping pills, which is simple, easy to implement, short in process, low in production cost and wide in application range, overcomes the drawbacks of the prior art and has wide market prospects.

Description

Technical field [0001] The invention relates to a preparation process of slow- and controlled-release micro-dropping pills, belonging to the technical field of pharmaceutical production. Background technique [0002] In recent years, with the wide application of pharmaceutical polymer materials and the in-depth study of drug delivery system (DDS), oral sustained or controlled release dosage forms are increasing. Compared with traditional preparations, this type of preparation has the characteristics of high efficacy, strong selectivity and good safety. And because of its high technical content and huge profits, it is valued by the pharmaceutical industry, and it is the most active system in application and development at present. Foreign countries did not start to develop oral sustained-release preparations in the 1950s. In the 1970s, the types of drugs approved for marketing continued to increase. By the end of the 1990s, the types of such preparations on the market had re...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/48A61K47/38A61K47/42A61K47/36A61K47/34A61K47/32A61K47/14A61K47/10
Inventor 孙民富
Owner 孙民富
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