Poly-sebacic acid glycerine ester biodegradable shape memory polymers and preparation method

Abstract

The invention relates to a poly sebacic-co-propanetriol ester biodegradable shape memory polymer and a preparation method thereof. The invention relates to a biodegradable shape memory polymer and the preparation method thereof. A product of the invention is formed by the copolymerization and the cross linking of sebacic acid and propanetriol. The method is as follows: a. a preformed polymer is prepared; and b. the product is obtained by moulding, cross linking and solidifying. The product has the advantages of large deformation, the high restoration ratio of deformation and good biocompatibility. The shape restoration temperature is 0 DEG C to 45 DEG C; the tensile strength is 0.5-10MPa; and the degradation time is 30 to 300 days. The poly sebacic-co-propanetriol ester biodegradable shape memory polymer can be used as material for repairing human body soft tissue injury, such as cornea, retina, skin, blood vessel, connective tissue, islet tissue, musculature, nervous tissue, etc. The method has simple technology and convenient operation.

Description

technical field [0001] The invention relates to a biodegradable shape memory polymer and a preparation method thereof. Background technique [0002] At present, the biodegradable shape memory polymers that have been developed include: Langer's research group uses poly-1,4-dioxane-2-ketone oligomer as the stationary phase, polycaprolactone oligomer or polylactide glycol Lactide copolymers are reversibly synthesized multi-block copolymers and polycaprolactone oligomers are reversibly synthesized methacrylate crosslinked polymers (US Patent 6160084), Yasuo Shikinami research group synthesized simultaneously with shape Memory properties, biodegradable and bioabsorbable polylactic acid (US Patent 6281262), etc.; but the shape recovery temperature of these existing materials is far from the body temperature, and the mechanical properties of human soft tissue are very different, and they are degraded Mechanisms all belong to bulk degradation; therefore it can only be used as the h...

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Problems solved by technology

[0002] At present, the biodegradable shape memory polymers that have been developed include: Langer's research group uses poly-1,4-dioxane-2-ketone oligomer as the stationary phase, polycaprolactone oligomer or polylactide glycol Lactide copolymers are reversibly synthesized multi-block copolymers and polycaprolactone oligomers are reversibly synthesized methacrylate crosslinked polymers (US Patent 6160084), Yasuo Shikinami research group synthesized simultaneously with shape Memory properties, biodegradable and bioabsorbable polylactic acid (US Patent 6281262), etc.; but the shape recovery temperature of these existing materials is far from the body temperature, and the mechanical properties of human soft tissue are very different, and they are degraded The mechanism belongs to the body degradation; therefore, it is only suitable for the hard tissue (such as bone) of the human body, and cannot be used as the soft tissue of the human body.