Titanic oxide solid lipid nano granule, fluid dispersion and preparation method thereof

A technology of solid lipid nano and titanium dioxide, which is applied in cosmetic preparations, cosmetics, pharmaceutical formulations, etc., can solve the problems of poor slow-release effect, short action time of sunscreen, poor effect of sunscreen, etc., and achieve good sustained release Effect, High Physiological Compatibility, Effect of Improving Action Effect

Active Publication Date: 2009-08-05
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Abstract
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Problems solved by technology

[0010] One of the purposes of the embodiments of the present invention is to provide a titanium dioxide solid lipid nanoparticle dispersion, which aims to solve the problem of the poor slow-release effect of the existing titanium dioxide anti-ultraviolet agent dispersion, the short action time of sunscreens, and the harmful effects of sunscreens on the skin. The problem of poor performance

Method used

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preparation example Construction

[0024] The preparation method of the above-mentioned nanoparticle dispersion comprises the following steps: dissolving titanium dioxide, lipid material, and emulsifier in an organic solvent according to the stated ratio to form an organic phase; heating the organic phase and the aqueous phase to the same temperature of 60-80°C respectively, The aqueous phase and the organic phase are uniformly mixed to form a clarified system; the clarified system is decompressed to remove the organic solvent for concentration, and stirred to cool down to room temperature to form a dispersion of solid lipid nanoparticles. The above-mentioned organic phase can also be added with an additive, the additive is 0-2 times the volume of the organic phase, preferably 0-0.3 times, selected from glycerol, propylene glycol, ethanol, 1,3 butanediol, manna or one of Several kinds.

[0025]The titanium dioxide solid lipid nanoparticles in the embodiment of the present invention are obtained by freeze-drying...

Embodiment 1

[0028] Dissolve 10mg of titanium dioxide, 100mg of stearic acid, and 200mg of poloxamer 188 in acetone, then add 15ml of ethanol to form the organic phase, slowly inject the 70-degree water phase into the organic phase at the same temperature with a syringe, and stir at constant temperature until clear. The clarified system was evaporated under reduced pressure with a rotary evaporator to remove the organic solvent and concentrated to 1 / 3 volume, while stirring and cooling down for 2 hours to form a suspension of solid lipid nanoparticles. Use a filter cloth to remove large particles, and store in a sealed container at 4 degrees. The titanium dioxide solid lipid nanoparticles can be obtained by freeze-drying.

Embodiment 2

[0030] Dissolve 80mg of titanium dioxide, 100mg of cetyl palmitate, and 180mg of poloxamer 188 in ethanol, and add 2ml of mannitol dropwise to form the organic phase. Slowly inject the 70-degree water phase into the organic phase at the same temperature with a syringe, and keep the temperature constant. Stir until clear. The clarified system was evaporated under reduced pressure with a rotary evaporator to remove the organic solvent and concentrated to 1 / 3 volume, while stirring and cooling down for 2 hours to form a suspension of solid lipid nanoparticles. Use a filter cloth to remove large particles, and store in a sealed container at 4°C to obtain a titanium dioxide solid lipid nanoparticle dispersion. Continue the freeze-drying process to obtain titanium dioxide solid lipid nanoparticles.

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Abstract

The invention provides a titanium dioxide solid lipid nanoparticle, a dispersion liquid thereof and a method for preparing the same. The dispersion is prepared from an organic phase and water phase, wherein the organic phase comprises titanium dioxide, a lipid material, an emulsifier and an organic solvent in sun-screening effective quantity; and the mass of the lipid material is 6 to 30 times that of the titanium dioxide, the emulsifier is 3 to 15 times of the lipid material, the mass of the organic solvent is 2 to 20 times of the total mass of the titanium dioxide, the lipid material and the emulsifier, and the volume of the water phase is 2 to 15 times of the organic phase. The titanium dioxide nanoparticle is coated in a carrier colloidal particle drug delivery system with slow release effect, thereby realizing the better slow release effect and prolonging the acting time of the sun-screening agent; and due to the cell membrane-similar structure of the solid lipid nanoparticle, the nanoparticle has the advantage of high physiological compatibility of the skin cells and also improves the effect of the sun-screening agent on the skin.

Description

technical field [0001] The present invention relates to the technical field of beauty, skin care and cosmetic chemicals, and specifically relates to a titanium dioxide solid lipid nanoparticle, its dispersion and a preparation method. Background technique [0002] Ultraviolet rays are one of the most harmful light waves in sunlight to the human body. Excessive exposure to ultraviolet rays can cause erythema and dark spots on the skin, accelerate skin aging, and seriously cause skin cancer. In recent years, with the expansion of the ozone layer, the harm of ultraviolet radiation has become increasingly serious. Among the ultraviolet rays that are harmful to the human body are generally UVB290nm-320nm in the medium-wave region and UVA320nm-400nm in the long-wave region. UVB causes erythema or blisters on the skin, promotes the formation of melanin, causes skin pigmentation, and significantly reduces enzyme and non-enzyme oxidants in the skin, thus weakening the ability of th...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/29A61Q17/04
Inventor 裴渭静李荣先王乃利阎玺庆曾嘉明
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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