Traditional Chinese medicine preparation for neurologic impairment due to craniocerebral trauma and post-operation and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine preparation for treating craniocerebral trauma and neurologic impairment caused by craniocerebral operations, which can effectively improve cerebral damaged motor nerves. The traditional Chinese medicine preparation is prepared from ginseng, angelica, hoantchy roots, flastem milkvetch seeds, medlar, red sage roots, pearl powder, earthworm, rhizoma gastrodiae, panax notoginseng, grassleaf sweelflag rhizome, hemlock parsley and kudzuvine roots. The preparation method comprises the following steps that: (1) the ginseng, the panax notoginseng, the rhizoma gastrodiae, the kudzuvine roots and the earthworm are broken into particles; the particles are added with ethanol, heated, refluxed, extracted, heated, concentrated and dried to be powder; and herb residue is reserved on standby; (2) the angelica and the hemlock parsley are soaked in water, heated and distilled; volatile oil is extracted; and the herb residue is reserved on standby; (3) the herb residue and residual medicine are combined, added with water and decocted; decoction is combined, filtered, concentrated and spray-dried; and (4) the volatile oil is added with water and beta-cyclodextrin, ground, included, filtered, dried, ground, well mixed with dry powder, sequentially added and well mixed with pearl powder and dextrin, added with the ethanol and dried. The preparation has the advantages of advanced technique, reasonable composition, no toxic-side effect and remarkable treatment effect.

Description

1. Technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine preparation for treating neurological deficits caused by craniocerebral trauma and craniocerebral surgery and a preparation method thereof. Traditional Chinese medicine is suitable for symptoms such as weak qi and blood, damaged brain vessels, unconsciousness due to stagnant meridians, crooked mouth and eyes, aphasia, dysphagia, limb paralysis accompanied by dizziness, headache, incontinence, and memory and cognitive impairment. 2. Background technology [0002] Craniocerebral trauma includes head injuries caused by bruises, falling injuries, gunshot wounds, industrial accidents, traffic accidents, etc., and brain injuries after craniotomy, such as confusion, aphasia, limb paralysis, crooked mouth and eyes, memory loss, etc. Handicap, mental retardation, incontinence, etc. The incidence rate is high, the mortality rate is high, and the disability rate is...

AI Technical Summary

Problems solved by technology

[0009] In view of the above situation, the object of the present invention is to provide a traditional Chinese medicine preparation for treating neurological deficits caused by craniocerebral trauma and craniocerebral surgery and its preparation method, which can effectively improve the damaged motor nerves of the brain, increase the blood flow of the brain, and reduce the Edema, increase the blood oxygen supply of the injured part, solve the current lack of drugs for targeted treatment of confusion, aphasia, and limb paralysis after craniocerebral injury, and similar drugs are mostly non-targeted and expensive. The traditional Chinese medicine preparation of the present invention is It is made of the following medicines by weight, and the total prescription quantity is: 140-170g of ginseng, 240-295g of angelica, 440-540g of astragalus, 400-490g of sandy fruit, 300-360g of medlar, 300-360g of salvia miltiorrhiza, 60-60g of pearl powder 75g, Earthworm 400-490g, Gastrodia elata 180-220g, Panax notoginseng 160-196g, Shichangpu 200-245g, Chuanxiong 240-295g, Pueraria 300-360g, the preparation method is realized by the following steps: ① First, ginseng, three 7. Gastrodia elata, kudzu root, and earthworm are broken into granules, add ginseng, notoginseng, gastrodia elata, kudzu root, earthworm weight and twice the mass concentration of 55-65% ethanol, heat at 50-70 ° C, reflux extraction 3 times, For 1.5-2.5 hours each time, heat and concentrate the obtained ethanol extract at 50-70°C, dry it into powder, and obtain the dry powder of alcohol extraction for later use; after ethanol extraction, ginseng, notoginseng, gastrodia elata, kudzu root, and earthworm medicine dregs for later use; ② take Angelica and Rhizoma Chuanxiong and add water to soak for 0.5-1.5 hours, heat and distill at 80-100°C for 1-1.5 hours, extract volatile oil, and set aside; after extracting volatile oil, dregs of Angelica and Rhizoma Chuanxiong are set aside; ③ Extract ethanol Combine the dregs of the medicine and the dregs after extracting the volatile oil with the remaining medicines, Astragalus membranaceus, Fructus Shayuanzi, Lycium barbarum, Salvia miltiorrhiza, and Shichangpu, and the amount of water added is 8 to 11 times the amount of medicinal materials except pearl powder in the total prescription amount. Boil 3 times, decoct for 1 hour each time, combine the decoction, filter, concentrate to a relative density of 1.04-1.08 (80°C thermal test), spray dry, and get a spray-dried powder for later use; ④ Add 10 to 20 times of water to the volatile oil Grinding and clathrate with β-cyclodextrin (the amount added is based on the principle that it can contain the volatile oil), and filtering to obtain the clathrate, drying at 50-65°C, crushing, and the above-mentioned alcohol extraction dry powder, spray-drying powder and mix evenly, add pearl powder, add 900-1100 grams of dextrin and mix evenly, add 1500-2000 ml of ethanol with a mass concentration of 90%, dry at 70-80°C to make granules, and obtain the traditional Chinese medicine preparation of the present invention

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