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Polyinosinic dropping-pills for pet and preparation method thereof

A technology of poly muscle cells and dripping pills, applied in the field of poly muscle cell dripping pills and their preparation, can solve the problems of pet owners inconvenience, pet stress, increase of secondary infection, etc., and achieves no injection, fast onset, accurate dose Effect

Inactive Publication Date: 2009-07-29
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is mainly used for the treatment of viral diseases in veterinary clinics, and its dosage form is mainly injections. However, the use of injections often causes stress on pets, directly affecting their growth and development and recovery from diseases. Since the injection needs to be carried out in a pet hospital, give pets Inconvenience to the host and possibly increased chance of secondary infection

Method used

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  • Polyinosinic dropping-pills for pet and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Prepare pH 7.2 sodium chloride-phosphate buffer solution, weigh the above-mentioned NaH 2 PO 4 12H 2 O0.262g, Na 2 HPO 4 2H 2 Dissolve O 3.895g and NaCl 8.768g in water respectively, mix well and dilute to 1000ml with water, the measured pH value should be 7.2±0.2;

[0031] 2. Take an appropriate amount of the above buffer solution preheated to 45°C in two containers, add 2 parts of polyinosinic acid and 2 parts of polycytidylic acid respectively, stir and dissolve, keep warm in a water bath at 45°C for 30 minutes, and combine the two solutions in it Wash the other container with a small amount of buffer solution, add the washing solution to the above solution, and keep warm at 45°C for 40 minutes, stirring gently during the heat preservation process.

[0032] 3. After the above-mentioned heat preservation is completed, the buffer solution is adjusted to 25ml, and stirred evenly.

[0033] 4. Add 46 parts of glucose to the prepared solution above, mix well, dry ...

Embodiment 2

[0038] 1. Prepare pH 6.6 sodium chloride-phosphate buffer solution, weigh NaH 2 PO 4 12H 2 O 4.35g, Na 2 HPO 4 2H 2 O 6.75g and NaCl 14.25g were dissolved in water respectively, mixed evenly and then diluted with water to 1000ml, the measured pH value should be 7.2±0.2.

[0039] 2. Take an appropriate amount of the above buffer solution preheated to 45°C in two containers, add 10 parts of polyinosinic acid and 10 parts of polycytidylic acid respectively, stir and dissolve, keep warm in a water bath at 45°C for 30 minutes, and combine the two solutions in it Wash the other container with a small amount of buffer solution, add the washing solution to the above solution, and keep warm at 45°C for 40 minutes, stirring gently during the heat preservation process.

[0040] 3. Dilute the solution after the above incubation to 50ml with buffer, and stir evenly.

[0041]4. Add the prepared solution above to 60 parts of lactose, mix well, dry under reduced pressure at 65°C to obta...

Embodiment 3

[0046] Sick dogs were randomly divided into groups, and those who showed fever (above 40°C), depression, refusal to eat, and vomiting were selected. The initial vomit is food, that is, mucus, yellow-green or blood. Diarrhea, the stool is loose, and with the development of the disease, the stool is coffee-colored or tomato-sauce-like bloody stool. Tenesmus, bloody stool with a special fishy smell. After a few hours of bloody stool, the sick dogs showed severe dehydration symptoms, sunken eyeballs, dry nose, decreased skin elasticity, and significant weight loss. The sick dogs with similar conditions were divided into experimental and control groups.

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Abstract

The invention relates to a polyinosinic acid drop pill for pets and a method for preparing the same. The drop pill is prepared from polyinosinic acid, polycytidylic acid, a pH buffering system, an excipient and a substrate.

Description

technical field [0001] The invention relates to a polykinocyte dripping pill for pets and a preparation method thereof. Background technique [0002] For pet viral diseases, such as canine coronavirus disease, canine parvovirus disease, rotavirus disease, canine parainfluenza, etc., veterinary clinics currently use symptomatic treatment, and there is no antiviral drug with good curative effect. Clinically, these diseases are usually treated symptomatically. At the same time, antibiotics were applied to prevent secondary infection. [0003] Polymyocytes, also known as polyinosine nucleotides and polycytosine nucleotides, are artificially synthesized double-stranded RNA polymers. Davies et al first synthesized it successfully in 1958. In 1967, Field and other experiments proved that polymyocytes are a kind of artificially synthesized strong inducer of interferon. In 1969, Group 824 of the Chinese Academy of Sciences began to develop polymyocytes in my country. In 1975, polym...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7105A61K48/00A61P31/12
Inventor 苏建东夏雪林李旭东
Owner TIANJIN RINGPU BIO TECH
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