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Cordyceps sinensis sustained and controlled release capsule and preparation method thereof

A Cordyceps Suspension and Capsule Technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as adverse overall health level, low dissolution rate, and long dissolution time limit to enhance human immunity. , the effect of reducing toxic and side effects and reducing the frequency of medication

Inactive Publication Date: 2009-07-15
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to preparation technology and other reasons, most Cordyceps medicines are oral preparations, especially oral preparations of traditional Chinese medicines, which have long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking them. problems, thus affecting the efficacy of the drug, and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause harm to the health of the staff to a certain extent, and will also cause environmental pollution. certain pollution
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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  • Cordyceps sinensis sustained and controlled release capsule and preparation method thereof
  • Cordyceps sinensis sustained and controlled release capsule and preparation method thereof
  • Cordyceps sinensis sustained and controlled release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of Cordyceps sustained-release capsules (specification: 10mg)

[0030] 1 Prescription: (1000 tablets for 10mg)

[0031] (1) Prepare drug-loaded pellets according to the following prescription:

[0032] Cordyceps active extract 80g, polyethylene glycol-4000 15g, polyvinylpyrrolidone 3g, 50% ethanol 10g, magnesium stearate 0.5g.

[0033] Immediate-release pellets were prepared according to the following formulation:

[0034] Drug-loaded pellets 100g, carboxypropylmethylcellulose 2.5g, polyethylene glycol-4000 15g;

[0035] Sustained-release pellets were prepared according to the following prescription:

[0036] Drug-loaded pellets 100g, carboxyethyl cellulose 20g, polyethylene glycol-6000 15g;

[0037] 2 Preparation method:

[0038] (1) Weigh the active extract of Cordyceps sinensis of prescription quantity, put polyethylene glycol-4000, polyvinylpyrrolidone in the mixer and mix evenly, add 50% ethanol to make soft material, sieve through 20-60 mesh, carr...

Embodiment 2

[0044] Preparation of Cordyceps capsules (specification: 10mg)

[0045] 1. Prescription (1000 tablets for 10 mg)

[0046] (1) Prepare drug-loaded pellets according to the following prescription:

[0047] Cordyceps active extract 80g, mannitol 37g, crospovidone 15g, PEG-2000 30g, 50% ethanol 10g, talcum powder 0.5g.

[0048] Immediate-release pellets were prepared according to the following formulation:

[0049] Drug-loaded pellets 100g, croscarmellose sodium 15g, PEG-2000 30g;

[0050] Sustained-release pellets were prepared according to the following prescription:

[0051] Drug-loaded pellets 100g, ethyl cellulose 15g, PEG-2000 30g;

[0052] 2 Preparation method:

[0053] (1) The active extract of Cordyceps sinensis, mannitol, crospovidone, and PEG-4000 are placed in a mixer to mix evenly, and an appropriate amount of 50% ethanol is added to make a soft material, and 20-60 meshes are sieved. Perform wet granulation.

[0054] (2) Dry at 40-60°C, and sieve the granules w...

Embodiment 3

[0059] Preparation of Cordyceps capsules (specification: 10mg)

[0060] 1. Prescription (1000 tablets for 10 mg)

[0061] (1) Prepare drug-loaded pellets according to the following prescription:

[0062] 80 parts of Cordyceps active extract, 15 parts of crospovidone, 15 parts of dextrin, 30 parts of PEG-1000, 5 parts of 50% ethanol, 0.5 parts of talcum powder, 5 parts of dilute alkali;

[0063] Immediate-release pellets were prepared according to the following formulation:

[0064] 100 parts of drug-loaded pellets, 37 parts of microcrystalline cellulose, 30 parts of PEG-1000;

[0065] Sustained-release pellets were prepared according to the following prescription:

[0066] 100 parts of drug-loaded pellets, 15 parts of croscarmellose sodium, 30 parts of PEG-4000;

[0067] 2 Preparation method:

[0068] (1) Take the active extract of Cordyceps sinensis of prescription quantity and place in the mixer with crospovidone, PEG-1000, dextrin and mix evenly, add appropriate amount...

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Abstract

The invention relates to a worm grass slowly controlled release capsule and a preparation method thereof. The capsule comprises 5 parts to 50 parts of quick release pillers and 50 parts to 95 parts of slow release pillers, each quick release piller comprises a core for carrying a pill and a protective layer, each slow release piller comprises a core for carrying a pill and a slowly controlled release coating layer, and the capsule has the dose of 30mg to 100mg. Medicine continuously released by the worm grass slowly controlled release capsule outside a body can reach more than 90 percent in 24 hours, a patient only needs to take medicine once every day, so times for taking medicine every day can be obviously reduced, the toxic side effect of medicine is lowered, the adaptability of the patient is enhanced and the abuse of medicine is not easy to occur.

Description

Technical field: [0001] The invention relates to a cordyceps slow-release and controlled-release capsule and a preparation method thereof, belonging to the technical field of extraction and application of active ingredients of traditional Chinese medicines. technical background: [0002] Cordyceps sinensis, also known as Cordyceps sinensis and Cordyceps sinensis, is a complex of larvae and larval corpses parasitized on the larvae of the larvae of the family Mothidae. Cordyceps sinensis is a traditional precious nourishing Chinese medicinal material, which is listed as the three major nourishing products together with natural ginseng and deer antler. It has mild medicinal properties and can be eaten all year round. It is suitable for the old, young, sick, weak, and weak. It has wider medicinal value than other types of tonics. Under the condition that the supply of Cordyceps sinensis is in short supply, its development and production have developed new sources of nutrition a...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61K9/52A61P3/06A61P9/10A61P25/20A61P29/00A61P31/04A61P35/00A61P39/00
Inventor 滕利荣逯家辉孟庆繁刘丹梅安金双王贞佐孟威吴凌
Owner JILIN UNIV
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