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Medicinal smectite content measuring standard

A technology of montmorillonite and content, which is applied in the direction of drug combination, material analysis using radiation diffraction, active ingredients of aluminum/calcium/magnesium, etc., can solve problems affecting clinical curative effect, can not effectively control drug quality, etc., to ensure clinical Curative effect, quality assurance effect

Inactive Publication Date: 2009-07-08
JINAN KANGZHONG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such standards cannot effectively control the quality of drugs, which in turn will affect clinical efficacy
[0022] The purpose of this invention is to provide a new standard that can effectively control the quality of medicinal montmorillonite in order to overcome the defects of silicon dioxide and aluminum oxide content standards in the existing medicinal montmorillonite quality standards

Method used

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  • Medicinal smectite content measuring standard

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Take bentonite and pulverize it, make X-ray diffraction patterns, and carry out qualitative and quantitative analysis. The result is that besides montmorillonite, it also contains about 30% of impurities such as illite and kaolinite. g, accurately weighed, put in a platinum crucible, add 0.5g sodium carbonate and 0.5g potassium carbonate, stir well, slowly raise the temperature, blaze at 800°C for 3 hours, cool, add dilute hydrochloric acid to a total of 50ml, stir to make the residue Completely dissolve and transfer to a 250ml beaker, wash the crucible with a small amount of water several times, put the lotion into the beaker, heat and evaporate about 1 / 2 volume of the solution, let it cool, add 20ml of hydrochloric acid and 1ml of 2% gelatin solution, at 60-70 Keep warm in a water bath at ℃ for 10 minutes, stir from time to time, filter while hot, and wash the container with hot water, collect the filtrate and lotion for later use; then transfer the filter paper and re...

Embodiment 2

[0048] Take an appropriate amount of zeolite, dry it at 105°C to constant weight, weigh about 1.0g, weigh it accurately, put it in a porcelain dish, add 6ml of sulfuric acid and 10ml of nitric acid, and wait until the effect is complete, put it on a sand bath and evaporate it to dryness, let it cool, and add to dilute Sulfuric acid 30ml, boiled, the supernatant was filtered through ash-free filter paper by pouring method, the residue was washed 3 times with hot water by pouring method, and the lotion was filtered together, and finally the residue was placed on the filter paper, washed with hot water, and the residue was Use as silicon dioxide; combine the filtrates, put them in a 100ml measuring bottle, let cool to room temperature, add water to dilute to the mark, and shake well; accurately measure 20ml, neutralize with ammonia test solution until precipitation occurs, then add dilute sulfuric acid dropwise Add 10ml of acetic acid-ammonium acetate buffer solution (pH6.0) until...

Embodiment 3

[0052] Take bentonite, add 8 times the amount of water and stir well, let it stand for 24 hours, absorb the upper suspension, discard the lower impurities, filter, dry the filter cake below 105°C, crush it, make an X-ray diffraction pattern, and conduct qualitative and quantitative analysis , the result was that the content of montmorillonite was 98%, weighed an appropriate amount, dried at 105°C to constant weight, weighed about 0.25g, accurately weighed, placed in a platinum crucible, heated to 900°C, ignited for 2 hours, cooled, and added sulfuric acid 0.2ml and 2ml ethanol to make the test product completely wet, add 6ml of hydrofluoric acid, evaporate at 100°C-300°C, add 6ml of hydrofluoric acid when it is almost dry, continue to evaporate until the gas is completely removed, and slowly heat up to 900°C , ignited for 1 hour, cooled, and accurately weighed. The weight difference between the two ignited results is the SiO content contained in the test product. 2 The amount ...

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Abstract

The invention discloses a standard for determining the content of medicinal montmorillonite, and in particular relates to a standard for controlling the content of silicon dioxide and aluminium sesquioxide in a quality standard of medicinal montmorillonite with pertinence. The standard is characterized in that the content standard of silicon dioxide and aluminium sesquioxide is as follows: the content of montmorillonite needs to be between 95.0 and 105.0 percent; according to the calculation of dry matter, the content of silicon dioxide (SiO2) needs to be between 55 and 65 percent; and the content of aluminium sesquioxide (Al2O3) needs to be between 12 and 22 percent.

Description

field of invention [0001] The invention relates to a standard for measuring the content of medicinal montmorillonite and belongs to the technical field of pharmaceutical standards. Background technique [0002] Montmorillonite is a drug that has been proved to be effective in treating diarrhea with few toxic and side effects. The existing quality standard for medicinal montmorillonite stipulates: calculated as dry product, containing silicon dioxide (SiO 2 ) should not be less than 50%, containing aluminum oxide (Al 2 o 3 ) should not be less than 10%. [0003] Montmorillonite is the main component of bentonite, which is obtained by washing bentonite with water to remove impurities. The main components of montmorillonite are silicon dioxide and aluminum oxide. Due to the different characteristics of bentonite ore-forming parent rock and mineralization and the preparation process of montmorillonite, besides montmorillonite, medicinal montmorillonite often has associated m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N23/20A61K33/06A61P1/12
Inventor 张梅雪许翠萍徐东峰张为胜李诗标
Owner JINAN KANGZHONG PHARMA TECH DEV
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