Production process of 2,6-diethyl-N-(2-propoxyethyl) acetanil

A technology of diethylaniline and propoxyethyl, which is applied in the preparation of carboxylic acid amides, the preparation of organic compounds, organic chemistry, etc., can solve the problems of low yield of finished products and few related reports, and achieve high yield of products, Raw materials are readily available and easy to operate

Inactive Publication Date: 2009-07-08
南通德益化工有限公司
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Problems solved by technology

[0002] 2,6-diethyl-N-(2-propoxyethyl)acetanilide (referred to as amino ether) is a new chemical intermediate, mainly used in pharmaceutical intermediates, pesticide intermediates, liquid crystal materials and other related fields ; With the continuous discovery of its new uses, its dosage is also more and more extensive, but its related reports are less, and the yield of finished products made by synthesis is low

Method used

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  • Production process of 2,6-diethyl-N-(2-propoxyethyl) acetanil
  • Production process of 2,6-diethyl-N-(2-propoxyethyl) acetanil
  • Production process of 2,6-diethyl-N-(2-propoxyethyl) acetanil

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Embodiment

[0024] Mix 1 mole of ethylene glycol monopropyl ether, 1.5 moles of triethylamine and an appropriate amount of esterification catalyst to react and stir, and cool down to 0-5°C by freezing brine (for example: 0°C, 1°C, 2°C, 3°C, 4°C , 5°C,), slowly add 1.1 moles of methanesulfonyl chloride dropwise, and the dropwise addition is completed in about 5 hours. After the reaction is completed, add an appropriate amount of water and stir for 2 hours, leave to separate and separate, and the oil layer is subjected to vacuum distillation to obtain the product sulfonyl chloride Esterate 167 grams.

[0025] Add 1 mole of 2,6-diethylaniline, 1 mole of sulfonate and an appropriate amount of etherification catalyst into the autoclave, and heat to 165-180°C (for example, 165°C, 169°C, 170°C, 175°C, 180°C ), kept warm for 5 hours, after the reaction was finished, drop liquid caustic soda to neutralize, add water to wash and separate layers to obtain an oil layer, and obtain 2,6-diethyl-N-(2-pr...

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Abstract

The invention discloses technology for preparing 2,6-diethyl-N-(2-propoxyl ethyl)acetanilide, which comprises: firstly, performing esterification reaction on ethylene glycol monopropyl ether, triethylamine and proper amount of esterifying catalyst; secondly, adding 2,6-diethylaniline, esterified sulfonic acid ester and a catalyst into an autoclave, and performing heating reaction and etherification reaction; and thirdly, adding refined ether, a toluene solvent, sodium carbonate and water into an acylation reaction kettle, reducing the temperature, dripping acetyl chloride, and performing acylation reaction to prepare finished products. The method has the advantages of easily obtained raw materials, easy operation and high product yield.

Description

technical field [0001] The invention relates to a production process of a new fine chemical material 2,6-diethyl-N-(2-propoxyethyl)acetanilide, referred to as amine ether. Background technique [0002] 2,6-diethyl-N-(2-propoxyethyl)acetanilide (abbreviated as amino ether) is a new chemical intermediate, mainly used in pharmaceutical intermediates, pesticide intermediates, liquid crystal materials and other related fields ; With the continuous discovery of its new uses, its usage is also more and more extensive, but its related reports are less, and the yield of finished products made by synthesis is low. Contents of the invention [0003] The invention provides a production process of 2,6-diethyl-N-(2-propoxyethyl)acetanilide. [0004] In order to solve the above technical problems, a kind of 2,6-diethyl-N-(2-propoxyethyl) acetanilide production technique of the present invention is characterized in that: mainly by esterification reaction, etherification reaction and acyl...

Claims

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Application Information

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IPC IPC(8): C07C233/88C07C231/02
Inventor 王莉马海兵贾庆山
Owner 南通德益化工有限公司
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