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Pig interferon inducer and use

A porcine interferon and interferon technology, applied in the field of veterinary medicine of antiviral protein, porcine interferon inducer, induced production of viral antibodies, and endogenous interferon, can solve the problem of obstructing the use of interferon, high price and production. Complex process and other problems, to achieve the effect of low price, simple production process and low production cost

Inactive Publication Date: 2009-06-24
HANGZHOU WONDERFUL BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Porcine interferon can be used to immunize swine fever, porcine pseudorabies virus, porcine blue ear virus, etc. However, due to the shortcomings of expensive interferon products on the market and complicated production processes, the use of interferon has been hindered

Method used

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  • Pig interferon inducer and use

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Accurately weigh and take 28.8% of purified porcine α-interferon, 5% of ginseng polysaccharide, 5% of ginsenoside, 1% of hydroxymethylpachyran, and 0.2% of versicolor glycopeptide, add 20% glycerin and 20% gelatin and mix thoroughly to prepare Suspension, packed into sterilized bottles, and then put into storage for quality inspection, and the finished product is stored in a dry and dark place.

[0018] The method of using the inducer: take it orally at a ratio of 0.1ml / Kg, and use it continuously for 7-10 days. Preparation process:

[0019]

Embodiment 2

[0020] Embodiment 2 Animal safety test

[0021] Experimental animals: 240 weaned piglets at the age of 21 days.

[0022] Experimental method: randomly divided into three groups, 80 rats in each group. The first group was used as a blank control group without administration of drugs; the second group fed the weaned piglets continuously for 7 days by taking the above products orally at a dose of 0.01ml / Kg, and the third group added western medicine, namely Fuluoxin soluble powder western medicine In the control group, the drug was given for 7 days, and the drug was stopped for one week to observe the growth and disease of weaned piglets.

[0023] See Table 1 for the experimental results.

[0024] Table 1

[0025] group Number of cases number of survivors number of deaths Morbidity mortality rate 1 13 76 4 16.25％ 5.00％ 2 4 80 0 5.00％ 0 3 9 77 3 11.25％ 3.75％

[0026] At the end of the experiment, it was observed that when the f...

Embodiment 3

[0029] Experimental animals: selected from 240 80Kg fattening pigs

[0030] Experimental method: randomly divided into three groups, 80 rats in each group. The first group was used as a blank control group without administration; the second group took the above products orally at a dose of 0.01ml / Kg, and fed the weaned piglets continuously for 7 days, and the third group added western medicine, Fuluoxin soluble powder western medicine control group, administered for 7 days, and stopped for one week to observe the growth and disease of weaned piglets.

[0031] See Table 2 for the experimental results.

[0032] Table 2

[0033] group Number of cases number of survivors number of deaths Morbidity mortality rate 1 18 77 3 22.50％ 3.75％ 2 2 80 0 2.50％ 0 3 9 78 2 11.25％ 2.50％

[0034] At the end of the experiment, it was found that when the first group was the blank control group, the pig incidence rate was 22.50%, among which swin...

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Abstract

The invention provides a pig interferon inducer. The active components of the pig interferon inducer consist of purified pig alpha-interferon, ginseng polysaccharide, ginsenoside, hydroxymethyl tuckahoe polysaccharide and polysaccharide-peptide. By weighing up the active components and adding with glycerin and gelatin for fully mixing, a suspending liquid is prepared, and the suspending liquid needs to be stored in light-shading places. For porcine reproductive respiratory syndrome, hog cholera and pseudorabies, the effective prevention rate of the pig interferon inducer provided by the invention is more than 70 percent. The invention provides a veterinary medicine which is safe, effective and low-priced, and can prevent diseases, and the cells are induced to generate the interferon by stimulating an animal body, so that the veterinary medicine has various biological activities of resisting virus in the broad spectrum, improving body immunity and the like, and the aims of preventing and curing viral diseases are achieved. The pig interferon inducer has the advantages of solving the problems of high production cost and inconvenient use existing in the leukocyte interferon and the recombination interferon of the pig, along with simple production process, low production cost and convenient popularization.

Description

technical field [0001] The invention belongs to the field of veterinary medicine and relates to a porcine interferon-inducing agent, in particular to a veterinary medicine induced to produce virus antibody, antiviral protein and endogenous interferon and its application. Background technique [0002] Interferon (IFN) is a broad-spectrum antiviral agent that does not directly kill or inhibit viruses, but is mainly produced by cells, lymphocytes and other body cells after the cell surface is stimulated by viruses or other interferon-inducing agents. The function of a highly active and multifunctional glycoprotein enables cells to produce antiviral proteins, thereby inhibiting virus replication; at the same time, it can also enhance the activity of natural killer cells (NK cells), macrophages and T lymphocytes, thereby It plays an immune regulation role, and enhances the antiviral ability, replacing the use of some antibiotics. Porcine interferon can be used to immunize swine ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/21A61K47/42A61P31/14A61K31/704A61K31/715
Inventor 姜礼辉刘韶娜陈伟东
Owner HANGZHOU WONDERFUL BIOTECH
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