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Composite aspartate, vitamin B6 and dipotassium glycyrrhetate eye drops without bacteria inhibitor and preparation method thereof

A technology of winter vegan and eye drops, which is applied in the field of compound aspart vegan eye drops and its preparation, can solve problems such as high risk, achieve cost savings, ensure sterility requirements, and avoid toxic and side effects

Inactive Publication Date: 2009-06-17
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially for eye drops that need to be used frequently, the potential danger is greater

Method used

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  • Composite aspartate, vitamin B6 and dipotassium glycyrrhetate eye drops without bacteria inhibitor and preparation method thereof
  • Composite aspartate, vitamin B6 and dipotassium glycyrrhetate eye drops without bacteria inhibitor and preparation method thereof
  • Composite aspartate, vitamin B6 and dipotassium glycyrrhetate eye drops without bacteria inhibitor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] prescription:

[0047]

[0048] Its preparation method:

[0049] a. Accurately weigh 7.8g aspartic acid and 0.5g vitamin B 6 , 1.0g dipotassium glycyrrhizinate, 0.03g naphazoline hydrochloride, 0.05g neostigmine methosulfate, 0.1g chlorpheniramine maleate, 1.0g polysorbate 80, 6.5g sodium chloride, 0.1g Mint, add 200mL of water for injection to dissolve, stir evenly, adjust the pH value to 5.0-6.0 with 5% sodium hydroxide solution, and dilute to 1000mL with water for injection to obtain a medicinal solution.

[0050] b. Filter the above medicinal solution once with a 0.45 μm microporous membrane, and then filter twice with a 0.22 μm microporous membrane under a Class 100 environment.

[0051] c. After the medicinal liquid is tested and passed, fill 0.4mL of the above medicinal liquid into a 1mL single-dose packaging plastic container in a class 100 environment, and seal it to obtain the finished product.

Embodiment 2

[0053] prescription:

[0054]

[0055] Its preparation method:

[0056] a. Accurately weigh 0.5g of sodium hyaluronate, add 300mL of water for injection to dissolve it, fully swell, and cool to obtain solution 1 for later use; accurately weigh 7.8g of aspartic acid and 0.5g of vitamin B 6 , 1.0g dipotassium glycyrrhizinate, 0.03g naphazoline hydrochloride, 0.05g neostigmine methosulfate, 0.1g chlorpheniramine maleate, 18.0g sodium citrate, add 200mL water for injection to dissolve, and dissolve it Stir and mix to obtain solution 2 for later use; mix solution 1 and solution 2, stir evenly, and dilute to 1000 mL with water for injection to obtain a medicinal solution.

[0057] b. Filter the above medicinal solution once with a 0.45 μm microporous membrane, and then filter twice with a 0.22 μm microporous membrane under a Class 100 environment.

[0058] c. After the medicinal liquid is tested and passed, fill 0.6mL of the above medicinal liquid into a 1mL single-dose packaging...

Embodiment 3

[0060] prescription:

[0061]

[0062] Its preparation method:

[0063] a. Accurately weigh 7.8g aspartic acid and 0.5g vitamin B 6 , 1.0g dipotassium glycyrrhizinate, 0.03g naphazoline hydrochloride, 0.05g neostigmine methosulfate, 0.1g chlorpheniramine maleate, 7.2g sodium dihydrogen phosphate, 0.9g disodium hydrogen phosphate, 12.0 g glycerin, add 200mL of water for injection to dissolve, stir evenly, and dilute to 1000mL with water for injection to obtain a medicinal solution.

[0064] b. Filter the above medicinal solution once with a 0.45 μm microporous membrane, and then filter twice with a 0.22 μm microporous membrane under a Class 100 environment.

[0065] c. After the medicinal liquid is tested and passed, fill 0.6mL of the above medicinal liquid into a 1mL single-dose packaging plastic container under a class 100 environment, and seal it to obtain the finished product.

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PUM

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Abstract

The present invention discloses compound aspartate, vitamin B6 and dipotassium glycyrrhetate eye drops which do not contain bacteriostat and a preparing method thereof, wherein the compound aspartate, vitamin B6 and dipotassium glycyrrhetate eye drops comprises aspartic acid, vitamin B6, dipotassium glycyrrhetate, naphazoline hydrochloride, neostigmine methysulfate, chlorpheniramine maleate, pH modifying agent, isoosmotic agent, stabilizing agent, thickening agent, algefacient, etc. The preparing method adopts an aseptic manipulation filling technique. Furthermore the eye drops of the invention adopt a disposable single-dose independent packaging. The sterilized performance of product is guaranteed. The product is safer, more reliable, easier and more sanitary.

Description

Technical field [0001] The invention belongs to the field of pharmaceuticals, and particularly relates to compound asparagine and viganone eye drops without bacteriostatic agents and a preparation method thereof. Background technique [0002] Compound Asparagine Vigan Eye Drops are used for the treatment of eye fatigue, chronic conjunctivitis, eye membrane congestion, and allergic conjunctivitis. Compound Vegan Aspartate Eye Drops that have been marketed all contain bacteriostatic agents and are packaged in multi-dose packages for repeated use. Once the preparation is opened, it is easily contaminated by tears and microorganisms in the air during use and storage, which may cause safety hazards. In order to prevent ophthalmic preparations from being contaminated by microorganisms during reuse after opening, bacteriostatic agents (preservatives) are added to ophthalmic preparations. Preservatives are used in almost all eye drop prescriptions in the "Chinese Hospital Preparati...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/198A61K31/4415A61K31/704A61K31/27A61K31/4402A61P27/02A61P27/14
Inventor 姚军
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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