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Hydroxyethyl starch 130/0.4 sodium chloride injection and preparation method and use thereof

A technology of sodium chloride injection and hydroxyethyl starch, which is applied in the fields of active ingredients of alkali/alkaline earth metal chlorides, blood diseases, and pharmaceutical formulations, to achieve low cost, avoid the occurrence of infectious diseases, and have a broad market prospect

Inactive Publication Date: 2012-01-18
CHENGDU ZHENGKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But a single hydroxyethyl starch 200 / 0.5 preparation can not meet the clinical needs

Method used

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  • Hydroxyethyl starch 130/0.4 sodium chloride injection and preparation method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] The preparation of embodiment 1 injection of the present invention

[0022] 1. Prescription composition

[0023] Hydroxyethyl starch 130 / 0.4 60g

[0024] Sodium chloride up to 9g

[0025] 0.1mol / L hydrochloric acid appropriate amount

[0026] Add water for injection to 1000ml

[0027] Each bottle contains hydroxyethyl starch 130 / 0.4 30g and sodium chloride 4.5g

[0028] 2. Production process

[0029] Pre-treatment: Process the infusion bottle, butyl rubber stopper and aluminum cap according to the injection requirements.

[0030] Concentrated preparation: Weigh the hydroxyethyl starch 130 / 0.4 and sodium chloride of the prescription amount, add them into the batching tank, and dissolve them completely with freshly prepared water for injection with a total volume of 50% under stirring.

[0031] Activated carbon adsorption: add 0.1% (g / ml) activated carbon for needles, boil for 20 minutes, decarbonize with a medium-speed sand filter, add water for injection to the fu...

Embodiment 2

[0038] The preparation of embodiment 2 injections of the present invention

[0039] Hydroxyethyl starch 130 / 0.4 20g

[0040] Sodium chloride up to 5g

[0041] Prepared according to the method of Example 1.

Embodiment 3

[0042] The preparation of embodiment 3 injections of the present invention

[0043] Hydroxyethyl starch 130 / 0.4 80g

[0044] Sodium chloride up to 13g

[0045] Prepared according to the method of Example 1.

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Abstract

The invention provides an ethoxyl starch 130 / 0.4 sodium chloride injection, in which, 20-80g of ethoxyl starch 130 / 0.4 and 5-13g of sodium chloride is include in per litre injection. The invention further provides the preparing method and application of the injection. The ethoxyl starch 130 / 0.4 in the raw material of the medicine in the invention is an improved product of 'heas' used clinically for treating and preventing hypovolemia, acute normovolemic hemodilution and so on. A better normovolemic therapeutic effect is achieved by optimizing molecular weight and molecular weight distribution, reducing displacement grade and changing displacement manner (C2 / C6); it can stays in blood for longer time after intravenous drip, consequently, can increase plasma osmotic pressure, tissue fluid back-flow and blood volume, can improve oxygenation condition in or after major operation evidently, and can increase tissue oxygen partial pressure and improve tissue oxygenation faster and earlier, thereby can satisfy the clinic demand better.

Description

technical field [0001] The invention relates to hydroxyethyl starch 130 / 0.4 sodium chloride injection, belonging to the pharmaceutical field. Background technique [0002] As a blood volume expansion drug, artificial colloid plays an extremely important role in the treatment and prevention of hypovolemia and shock. Compared with blood plasma, albumin and crystalloid, artificial colloid has the advantages of low cost and long action time as blood volume expansion drug, and can effectively avoid the occurrence of infectious diseases caused by the use of blood products. The hydroxyethyl starch solution made of corn starch is the third generation artificial colloid after gelatin and dextran colloids. Since it was introduced into clinical practice in 1962, after more than 30 years, due to continuous replacement and renewal, it has gradually become the most popular in European and American countries. A popular plasma expander with broad market prospects. [0003] At present, hy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/718A61K33/14A61P7/00
Inventor 朱贞华
Owner CHENGDU ZHENGKANG PHARMA
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