Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ainsliaea fragrans Champ total flavone extract and extraction method and use thereof

A technology of apricot rabbit ear wind and extract, which is applied in the field of medicine, can solve the problems of outdated preparation process, large daily dosage, and low content of active ingredients, and achieve the effect of convenient operation, good repeatability, and simple process

Inactive Publication Date: 2009-03-11
SHENYANG PHARMA UNIVERSITY
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current commercially available rabbit ear wind preparations have outdated preparation methods, all of which are preparations after simple extraction of apricot fragrance rabbit ear wind, with low active ingredient content and large daily dose

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ainsliaea fragrans Champ total flavone extract and extraction method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Get 1 kg of rabbit ear wind medicinal material, pulverize, pass through a 20-mesh sieve, add 12000 ml of ethanol solution with a volume fraction of 5% prepared by a calcium hydroxide solution with a pH value of 9, reflux extraction for 2 hours, filter and save the filtrate, and repeat the operation for 3 Second-rate. The three filtrates were combined, the filtrate was concentrated to about 2 mg / ml of flavonoids, extracted three times with petroleum ether, and the aqueous layer was retained. The macroporous resin column that has been treated on the mother liquor (soaked in 95% ethanol for 12 hours, then eluted for 2-4 volumes with 95% ethanol, and then eluted with distilled water until the eluent has no alcohol smell), the flow rate is 1ml / min. Elute with a large amount of distilled water until the eluate is colorless, elute with 5 volumes of 10% ethanol, collect the eluate with 10% ethanol, concentrate and evaporate to dryness to obtain the purified rabbit ear wind, t...

Embodiment 2

[0016] Get 1 kg of rabbit ear wind medicinal material, pulverize, pass through a 20-mesh sieve, add 12000 ml of ethanol solution with a volume fraction of 10% prepared by a calcium hydroxide solution with a pH value of 8, reflux extraction for 2 hours, filter and save the filtrate, and repeat the operation for 3 Second-rate. The three filtrates were combined, the filtrate was concentrated to about 2 mg / ml of flavonoids, extracted three times with petroleum ether, and the aqueous layer was retained. The macroporous resin column that has been treated on the mother liquor (soaked in 95% ethanol for 12 hours, then eluted for 2-4 volumes with 95% ethanol, and then eluted with distilled water until the eluent has no alcohol smell), the flow rate is 1ml / min. Elute with a large amount of distilled water until the eluate is colorless, elute with 5 volumes of 30% ethanol, collect the eluate with 30% ethanol, concentrate and evaporate to dryness to obtain the purified rabbit ear wind, ...

Embodiment 3

[0018] Take 1 kg of rabbit ear wind medicinal material, pulverize, pass through a 20-mesh sieve, add 12000 ml of ammonia water with a pH value of 8 to prepare a 30% ethanol solution, reflux extraction for 2 hours, filter and save the filtrate and repeat the operation 3 times. The three filtrates were combined, the filtrate was concentrated to about 2 mg / ml of flavonoids, extracted three times with petroleum ether, and the aqueous layer was retained. The macroporous resin column that has been treated on the mother liquor (soaked in 95% ethanol for 12 hours, then eluted for 2-4 volumes with 95% ethanol, and then eluted with distilled water until the eluent has no alcohol smell), the flow rate is 1ml / min. Elute with a large amount of distilled water until the eluate is colorless, elute with 30% ethanol for 5 volumes, collect the eluate with 30% ethanol, concentrate and evaporate to dryness to obtain the purified rabbit ear wind, the total flavonoid content is about 69% .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the pharmaceutical technology field and provides an extract of total flavonoids of frangrant ainsliaea herb, an extraction method thereof and a use. The extract adopts the frangrant ainsliaea herb as a raw material, ethanol which is prepared by weak alkaline solutions with the different pH values is taken as an extraction solvent, the reflux extraction is adopted, the impurities are removed by the petroleum ether extraction, the separation and the enrichment are finally carried by macroporous resin, and the purity of the components of the obtained total flavonoids is 50-95 percent. The invention has simple process, convenient and safe operation and good repeatability and can be used for the industrial production. The invention further provides an application of the components of the total flavonoids or a preparation which is prepared by the total flavonoids and a pharmaceutically acceptable carrier in the prepration of drugs for treating acute and chronic cervicitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an extract of total flavonoids from apricot and rabbit ear wind, an extraction method and application thereof. Background technique [0002] Apricot-fragrance rabbit ear wind is a common folk medicine, which is the dried whole herb of Ainsliaea fragrans Champ. Apricot Fragrant Rabbit Ear Wind is sweet in nature and flavor, slightly bitter, cool in nature, and returns to the lung and liver channels. It has the effects of clearing away heat and invigorating deficiency, cooling blood for hemostasis, promoting dampness and detoxification. Indications for consumptive bone steaming, pulmonary rash and hemoptysis, women's uterine bleeding, damp-heat jaundice, edema, carbuncle and swelling, scrofula and tuberculosis, bruises, snake bites, etc. Clinically, Xingxiang rabbit ear wind preparation and folk prescriptions are used to treat cervical erosion, endometritis, hot boils, thrush and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/28A61P15/00
Inventor 王淑君邱宁周国勤杨瑞
Owner SHENYANG PHARMA UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com