Diabecron sustained-release tablet and preparation method thereof

A technology of metformin hydrochloride and sustained-release tablets, which is applied to the oral drug metformin hydrochloride for treating diabetes and its preparation, and the field of sustained-release tablets and its preparation, can solve the problem that the timed and quantitative release of drugs and release can not be achieved well. Large difference, instability and other problems, to achieve the effect of reliable treatment and self-prevention of sudden onset, small difference in release, and safety

Active Publication Date: 2011-07-27
QINGDAO HUANGHAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the existing metformin hydrochloride slow-release tablet that is made with common macromolecule material releases in vitro and has certain disparity, is not very stable between every batch, especially between each sheet after 10 hours and between each batch release difference is bigger, can't It is very good to achieve the purpose of timing and quantitative release of drugs

Method used

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  • Diabecron sustained-release tablet and preparation method thereof
  • Diabecron sustained-release tablet and preparation method thereof
  • Diabecron sustained-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The metformin hydrochloride sustained-release tablet includes a main drug, a sustained-release material and other auxiliary materials, and is characterized by being formulated in the following weight percentages: 68% of the main drug, 19% of sustained-release materials, and 13% of other auxiliary materials.

[0041] The sustained-release tablet is prepared from the following raw materials in weight ratio:

[0042] 1000 tablets prescription

[0043] Metformin hydrochloride 68%

[0044] Hypromellose K100 16.3%

[0045] Glyceryl behenate 2.7%

[0046] Lactose 6.8%

[0047] Polyvinylpyrrolidone K90 3%

[0048] Dry accessories:

[0049] Magnesium stearate 1.4%

[0050] Talc 1.8%

[0051] 1000 pieces in total

[0052] The above-mentioned hypromellose K100 and glyceryl behenate are slow-release agents, lactose is a filler, talc and magnesium stearate are lubricants, and polyvinylpyrrolidone K90 in ethanol is a binder.

[0053] Preparation:

[0054] Prepare the materials according to the componen...

Embodiment 2

[0056] The metformin hydrochloride sustained-release tablet includes a main drug, a sustained-release material and other auxiliary materials, and is characterized in that it is formulated in the following weight percentages: 68% of the main drug, 18% of the sustained-release material, and 14% of other auxiliary materials.

[0057] The sustained-release tablet is prepared from the following raw materials in weight ratio:

[0058] 1000 tablets prescription

[0059] Metformin hydrochloride 68%

[0060] Hypromellose K100 12%

[0061] Glyceryl behenate 6%

[0062] Lactose 7%

[0063] Polyvinylpyrrolidone K90 3.8%

[0064] Dry accessories:

[0065] Magnesium stearate 1.4%

[0066] Talc 1.8%

[0067] 1000 pieces in total

[0068] The above-mentioned hypromellose K100 and glyceryl behenate are slow-release agents, lactose is a filler, talc and magnesium stearate are lubricants, and polyvinylpyrrolidone K90 in ethanol is a binder.

[0069] Preparation:

[0070] Prepare the materials according to the comp...

Embodiment 3

[0072] The metformin hydrochloride sustained-release tablet includes a main drug, a sustained-release material and other auxiliary materials, and is characterized by being formulated in the following weight percentages: 68% of the main drug, 22% of the sustained-release material, and 10% of other auxiliary materials.

[0073] The sustained-release tablet of the present invention is prepared from the following raw materials with a weight ratio:

[0074] 1000 tablets prescription

[0075] Metformin hydrochloride 68%

[0076] Hypromellose K100 20%

[0077] Glyceryl behenate 2%

[0078] Lactose 4.8%

[0079] Polyvinylpyrrolidone K90 2%

[0080] Dry accessories:

[0081] Magnesium stearate 1.4%

[0082] Talc 1.8%

[0083] 1000 pieces in total

[0084] Among them, hypromellose K100 and glyceryl behenate are slow-release agents, lactose is a filler, talc and magnesium stearate are lubricants, and polyvinylpyrrolidone K90 in ethanol is a binder.

[0085] Preparation:

[0086] Prepare the materials accor...

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Abstract

The invention discloses a metformin hydrochloride slow release tablet which is prepared from the following materials according to the weight proportion: 68% of metformin hydrochloride, 18-22% of a slow release material and the residual amount of a pharmaceutic adjuvant, wherein, the slow release material takes the compound of hydroxypropyl methylcellulose K100 and glyceryl behenate, and the weight ratio of the hydroxypropyl methylcellulose K100 and the glyceryl behenate is 1:0.1-0.5. The metformin hydrochloride slow release tablet has the advantages of small in vitro release difference among tablets and batches, good curative effect, long drug action, little side effect, few administration frequency, convenient use and the like, and has unique advantages of treating and relieving type II diabetes symptoms, preventing sudden onset of diseases, protecting the daily life of patients and bringing the patients through the onset peaks; and the slow release provides reliable measures and great convenience for the treatment of the patients and self prevention of the sudden onset of diseases.

Description

Technical field [0001] The invention relates to a sustained-release tablet for treating diabetes and a preparation method thereof, in particular to a sustained-release tablet of metformin hydrochloride, an oral drug for treating diabetes, and a preparation method thereof. It belongs to the technical field of pharmaceutical preparations. Background technique [0002] Metformin Hydrochloride Sustained-Release Tablets were developed by Qingdao Huanghai Pharmaceutical Co., Ltd. and were approved in January 2004 for use in type II diabetes. The trade name is Mattmei. The dosage form is a sustained-release tablet with a dose of 500 mg / tablet. Usage and dosage: Orally once a day, 1 tablet each time, the maximum daily dose does not exceed 4 tablets. [0003] Diabetes can have many complications, some of which directly threaten the lives of patients. The risk of cardiovascular disease and stroke in type II diabetes is 2 to 4 times higher than that of the general population, and patients...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/155A61P3/10
Inventor 吴康孙桂荣袁芳
Owner QINGDAO HUANGHAI PHARM CO LTD
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