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Method for fast choosing technological condition for preparing nanometer medicine-loading fibre felt by electro spinning

A technology of process conditions and nano-drug loading, applied in fiber processing, fiber chemical characteristics, rayon manufacturing, etc., can solve the problems of high cost, complicated processing, inconvenience, etc., and achieve short time consumption, simple operation, and controlled release performance. excellent effect

Inactive Publication Date: 2009-02-18
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For the observation of the morphology of electrospun fiber mats, most of the literature currently uses scanning electron microscopy for observation, and occasionally transmission electron microscopy and atomic force microscopy for observation. Although the results are good, these methods are expensive and the pre-treatment for observation is complicated. As a result, the cycle is long. In the process of preparing drug-loaded fiber mat by electrospinning, it is necessary to observe a large number of samples in advance and select and optimize the preparation process parameters. Therefore, it is not only inconvenient, but also expensive. If the electrospinning process can be optimized through a simple and practical The conditions are undoubtedly very favorable for the expansion of the electrospinning process and the development and application of drug-loaded fiber mats

Method used

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  • Method for fast choosing technological condition for preparing nanometer medicine-loading fibre felt by electro spinning
  • Method for fast choosing technological condition for preparing nanometer medicine-loading fibre felt by electro spinning
  • Method for fast choosing technological condition for preparing nanometer medicine-loading fibre felt by electro spinning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of drug-loaded fiber mats using different solvents to prepare PAN spinning solutions by electrospinning

[0025] The drug-loaded fiber spinning solution was prepared according to the following steps: 10g of acyclovir was dissolved in 1000mL of dimethylacetamide (DMAc) in a water bath at 60°C; then 90g of polyacrylonitrile (PAN) fine powder was added Wherein, it was swelled for 24 hours under stirring at 250 rpm and a water bath at 60° C.; cooled to room temperature to prepare for spinning.

[0026] Prepare the spinning stock solution of acyclovir of dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) in the same steps and ratio.

[0027] Pour the prepared solution into the solution reservoir (5mL syringe), use the flattened No. 6 injection needle as the capillary for spraying thin stream, connect the positive electrode of the high-voltage power supply, and connect the negative electrode to the aluminum foil fiber receiving plate with the glass s...

Embodiment 2

[0028] Embodiment 2: Observation of PAN drug-loaded fiber mat under different solvents by polarizing microscope

[0029] Carefully remove the downloaded glass slide, cover it with a cover glass, and fix it under a polarizing microscope. The polarizer and the analyzer are orthogonally interleaved, and observed under high magnification (objective lens 63 times × shooting magnification 16 times), and use Recorded by Canon digital cameras. The result is as figure 2 As shown, the spinning dope prepared by DMSO has a high volatilization point, which leads to serious adhesion phenomenon. Due to the low solubility of the drug in DMF and fast volatilization, although the diameter of the spun fiber is small, some crystals are separated out. , It is easy to cause the initial burst release effect of drug release, so it is better to use DMAc in the preparation of PAN drug-loaded fibers of acyclovir. Wherein, when DMAc solvent is used, the diameter range of the PAN drug-loaded fiber of a...

Embodiment 3

[0030] Example 3: Preparation of Eudragit III drug-loaded fibers with different ibuprofen concentrations by electrospinning and polarized light observation

[0031] Dissolve 5, 10, and 20 g of ibuprofen in 500 mL of methanol at room temperature, respectively; then add 100 g of Eudragit III into it, swell for 2 hours under stirring at 250 rpm, and then ultrasonically degas.

[0032] Pour the prepared solution into the solution reservoir (5mL syringe), use the flattened No. 6 injection needle as the capillary for spraying thin stream, connect the positive electrode of the high-voltage power supply, and connect the negative electrode to the aluminum foil fiber receiving plate with the glass slide, and the solution The ejection volume was controlled by a micro-syringe pump, and electrospinning was carried out for 10 minutes under the following conditions: the flow rate was 1.0 mL h -1 , the distance between the receiving plate and the spinneret is 15cm, the voltage is 15kV, the am...

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Abstract

The invention relates to a method for speedily selecting the technical conditions for fabricating nano drug carrying fiber felt through electrospinning. The method collects nano or ultra-thin fiber through a glass slide and selects the optimal technical conditions for electrospinning by observing the form of the fiber and the existing state of the drug in the fiber through orthogonal polarization of a polarizing fiber scope and by estimating the diameter of the fiber according to the graduation on the glass slide to fabricate nano or ultra-thin fiber felt which is excellent in drug carrying, controlling and releasing performances. The invention is widely applicable in the processes of selecting and optimizing the technological conditions for electrospinning various materials and composite materials into fiber.

Description

technical field [0001] The invention belongs to the field of selection of preparation process conditions for drug-loaded fiber mats, in particular to a method for rapidly selecting process conditions for preparing nanometer drug-loaded fiber mats by electrospinning. Background technique [0002] In recent years, since nanomaterials and grafted modified fibers have become research hotspots, people have paid great attention to the application of electrospinning technology. This technology is a top-down technology for preparing nanomaterials, which can economically prepare nanoscale fibers. Taking advantage of the performance advantages of nanofibers, many researchers have attempted to mix drugs into electrospun nanofibers to prepare matrix-type controlled-release drug delivery systems. [0003] Electrospinning device such as figure 1 , generally consists of a high-pressure generator, a spinneret, a micro-injection pump and a collection device. Unlike traditional spinning, w...

Claims

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Application Information

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IPC IPC(8): D04H13/00D01D5/00D01F1/10D01F6/54
Inventor 朱利民申夏夏余灯广张晓飞
Owner DONGHUA UNIV
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