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Preparation method of controlled release hydrogel used for tumor postoperative chemotherapy magnetic-thermal and photo-thermal combined treatment

A combined therapy and hydrogel technology, which is applied in the field of controlled-release hydrogel preparation, can solve the problems of inability to remove tumors, trauma and complications of patients, and normal cell damage, and achieve easy storage, reduced dosage, Effect of Good Controlled Release Properties

Inactive Publication Date: 2019-10-08
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods all have great risks, which are likely to bring great trauma and complications to patients, and at the same time, they are likely to cause great damage to normal cells while killing cancer cells.
At present, the treatment of tumors in our country is still based on surgical resection, but most of the operations cannot completely remove the tumor, which leads to tumor recurrence.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1) Add 1 g of carboxymethyl chitosan to 47 mL of MES buffer and stir for 2 h;

[0037] 2) Dissolve 85mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 51mg of N-hydroxysuccinimide in 1mL of MES buffer respectively;

[0038] 3) Put the solution in step 1) in a water bath and heat up to 60°C, and add the 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloric acid solution in step 2) under nitrogen protection and N-hydroxysuccinimide solution. Stir for 1 h, during which the pH of the solution is maintained at 5 with hydrochloric acid or sodium hydroxide;

[0039] 4) Finally, add 550 mg of dopamine to the solution obtained in step 3), and then react for 12 hours under stirring, and maintain the pH of the solution at 5 with hydrochloric acid or sodium hydroxide during stirring;

[0040] 5) The solution obtained in step 4) was placed in an 8000 Da dialysis bag and dialyzed in deionized water in an acidic environment for 2 days, then frozen in an ultr...

Embodiment 2

[0049] 1) Add 1.25g carboxymethyl chitosan to 47.5mL MES buffer, stir for 2h;

[0050] 2) Dissolve 87.5 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 53 mg of N-hydroxysuccinimide in 1.25 mL of MES buffer respectively;

[0051] 3) Put the solution in step 1) in a water bath and heat up to 60°C, and add the 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloric acid solution in step 2) under nitrogen protection and N-hydroxysuccinimide solution. Stir for 1.25h, and maintain the pH of the solution at 5 with hydrochloric acid or sodium hydroxide during stirring;

[0052] 4) Add 570 mg of dopamine to the solution obtained in step 3), and react under stirring for 14 hours. During the stirring, use hydrochloric acid or sodium hydroxide to maintain the pH of the solution at 5;

[0053] 5) The solution obtained in step 4) was placed in an 8000 Da dialysis bag and dialyzed in deionized water in an acidic environment for 2 days, then frozen in an ultra-low ...

Embodiment 3

[0062] 1) Add 1.5g carboxymethyl chitosan to 48mL MES buffer, stir for 2h;

[0063] 2) Dissolve 90mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 55mg of N-hydroxysuccinimide in 1.5mL of MES buffer respectively;

[0064] 3) Put the solution in step 1) in a water bath and heat up to 60°C, and add the 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloric acid solution in step 2) under nitrogen protection and N-hydroxysuccinimide solution. Stir for 1.5h, and maintain the pH of the solution at 6 with hydrochloric acid or sodium hydroxide during stirring;

[0065] 4) Add 600 mg of dopamine to the solution obtained in step 3), and then react for 16 hours under stirring, and maintain the pH of the solution at 6 with hydrochloric acid or sodium hydroxide during stirring;

[0066] 5) The solution obtained in step 4) was placed in an 8000 Da dialysis bag and dialyzed in deionized water in an acidic environment for 3 days, then frozen in an ultra-low temperat...

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Abstract

The invention relates to the field of biomedical high polymer materials and discloses a preparation method of controlled release hydrogel used for tumor postoperative chemotherapy magnetic-thermal andphoto-thermal combined treatment. Carboxymethyl chitosan-dopamine with good biocompatibility is utilized to be loaded with ferroferric oxide@melanin-PEG@dopamine nano particles with good photo-thermal performance and magnetic-thermal performance, and indocyanine green with photo-thermal performance and photodynamic performance, and thus the hydrogel with a controlled release function for tumor postoperative magnetic-thermal, photo-thermal and photodynamic combined treatment. The hydrogel can conduct photo-thermal, photodynamic and magnetic-thermal treatment on postoperative tumor parts. Meanwhile, the hydrogel has good controlled release performance, the effects of decreasing the drug administration dosage, and reducing or avoiding toxic and side reaction are realized, the stability of adrug is improved, and storage is facilitated; and some new drug administration approaches can be established.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, in particular to a method for preparing a controlled-release hydrogel used in postoperative chemotherapeutic magnetothermal-photothermal combined therapy. Background technique [0002] Surgery, radiotherapy, and chemotherapy are currently the main means and methods of cancer treatment. These methods all have great risks, and are likely to cause major trauma and complications to patients. At the same time, they are likely to cause greater damage to normal cells while killing cancer cells. At present, the treatment of tumors in my country is still dominated by surgical resection, but most operations cannot completely remove the tumor, which leads to tumor recurrence. After surgical resection of the tumor, in order to remove the remaining tumor tissue, we need a treatment method that can act in a small local area and with milder conditions to achieve this goal. Heat, photothermal and ph...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/61A61K47/59A61K47/60A61K41/00A61P35/00
CPCA61K41/0052A61K41/0057A61K47/59A61K47/60A61K47/61A61K47/6903A61P35/00A61K2300/00
Inventor 王秉金小康邱方燚蒋鹏彭志勤
Owner ZHEJIANG SCI-TECH UNIV
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