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Medicine for hemorrhage after drug abortion

A technology of medicine and main medicine, applied in the field of medicine for bleeding after medical abortion, can solve the problems of ineffectiveness and secondary pain of patients

Active Publication Date: 2009-01-07
JUMPCAN PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Treatment with anti-inflammatory, hemostatic, uterine contraction or anti-fibrinolytic drugs is difficult to be effective, and often requires curettage, which brings secondary pain to the patient

Method used

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  • Medicine for hemorrhage after drug abortion
  • Medicine for hemorrhage after drug abortion
  • Medicine for hemorrhage after drug abortion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Radix Astragali 500g, Panax notoginseng 200g, Codonopsis 400g, Rehmannia glutinosa 400g, Peach kernel 400g, Angelica 400g, Motherwort 400g, Rubia 400g, Dipsacus 400g, Sea octopus 800g, Sacred vine 400g. in:

[0054] (1) Add 4 times the amount of water to Angelica sinensis, soak for 1 hour, extract the volatile oil with steam distillation for 4 hours, and collect the volatile oil and the distilled extract in another device;

[0055] (2) Radix Notoginseng plus 60% ethanol for reflux extraction twice, add 7 times the amount of alcohol for the first time, add 5 times the amount for the second time, each time for 1.5 hours, combine the alcohol extracts, filter, and recover the ethanol from the filtrate under reduced pressure. The relative density is 1.08-1.10 (60°C), dried under reduced pressure, and pulverized to obtain the dry extract powder of notoginseng alcohol;

[0056] (3) Panax notoginseng, dregs of angelica and other medicinal materials are decocted and extracted 3...

Embodiment 2

[0058] Example 2: Effects on the amount of uterine bleeding and endometrial morphology after drug abortion in rats

[0059] 1. Drugs

[0060] Medicinal dry paste powder of the present invention: prepared according to the method of the above-mentioned embodiment 1, without adding auxiliary materials such as dextrin and aspartame. Each gram of dry cream powder is equivalent to 7.50g of crude drug.

[0061] Positive control drug: Gongxuening capsule: 0.13g / capsule, product of Yunnan Baiyao Group Co., Ltd., batch number: 20031002.

[0062] Mifepristone tablet: 25mg / tablet, product of Beijing Zizhu Pharmaceutical Co., Ltd., batch number: 43041001.

[0063] Misoprostol tablets: 0.2mg / tablet, product of Beijing Zizhu Pharmaceutical Co., Ltd., batch number: 41030409.

[0064] 2. Method

[0065] Rats were mated in cages at a ratio of 2:1 female to male for 4 consecutive days. Vaginal smear examination was carried out every morning, and the female mouse with sperm was taken out, an...

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PUM

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Abstract

The invention provides a medicament for treating hemorrhage after drug abortion, the preparation method and the application thereof. The medicament comprises the following basic materials by the weight part: 0.5 to 1.5 parts of notoginseng, 2 to 3 parts of milkvetch root, 1.5 to 2.5 parts of radix codonopsitis, 1.5 to 2.5 parts of rehmannia root, 1.5 to 2.5 parts of peach seed, 1.5 to 2.5 parts of angelica root, 1.5 to 2.5 parts of herba leonuri, 1.5 to 2.5 parts of indian madder root, 1.5 to 2.5 parts of himalayan teasel root, 3 to 5 parts of cuttlebone and 1.5 to 2.5 parts of caulis sargentodoxae. The medicament has good curative effects on hemorrhage, particularly after drug abortion, artificial abortion or parturition, or hemorrhage caused by lochiorrhagia and placenta retension after childbirth or abortion.

Description

technical field [0001] The invention provides a medicine for bleeding after medical abortion, its preparation method and application. The medicines are calculated in parts by weight and include the following main ingredients: 0.5-1.5 parts of notoginseng, 2-3 parts of astragalus, 1.5-2.5 parts of codonopsis, 1.5-2.5 parts of rehmannia glutinosa, 1.5-2.5 parts of peach kernels, and 1.5-2.5 parts of angelica , 1.5-2.5 parts of motherwort, 1.5-2.5 parts of madder, 1.5-2.5 parts of Dipsacus, 3-5 parts of sea octopus, and 1.5-2.5 parts of S. Drugs have a good therapeutic effect on bleeding, especially gynecological medical abortion, bleeding after abortion or childbirth, or postpartum lochia, persistent afterbirth or bleeding caused by abortion. It belongs to the field of medicine. Background technique [0002] Vaginal bleeding after medical abortion continues for a long time, which is one of the common, frequently-occurring and difficult diseases in obstetrics and gynecology. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P7/04A61K35/56A61K35/618
Inventor 曹龙祥刘昭阳李昌龙田刚杨学芳
Owner JUMPCAN PHARMA GRP
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