Preparation method of lipid microspheres combined by salvia lipid extract and poppy seed oil

A technology of lipid microspheres and extracts, applied in the field of drug preparation, can solve the problems of retardation, digestive system disorder, oil leakage and the like

Inactive Publication Date: 2011-09-28
HEILONGJIANG BAOQINGLONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although poppy seed oil has good nutritional value, taking this crude oil-based preparation, like taking other crude oil-based preparations, often causes diarrhea and digestive system disorders
On the other hand, due to the ubiquitous problems of oil leakage, hardening and slow disintegration of crude oil soft capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Take 100g of poppy seed oil, 2g of tanshinone IIA, 20g of polyene phosphatidylcholine, 100mg of vitamin E, 2g of oleic acid, 25g of glycerin, 35mg of sodium hydroxide, and add water to 1000ml; Inject nitrogen to return to normal pressure. Under the protection of nitrogen, take poppy seed oil and put it in an oil tank, add polyene phosphatidylcholine and vitamin E, and slowly heat up to 70°C under stirring to make the polyene phosphatidylcholine Dissolve in alkali, add tanshinone IIA and sodium oleate in turn and stir until completely dissolved, keep temperature, nitrogen protection, and form an oil phase; take sterile water into the water tank of the emulsification system, fill the water with nitrogen to remove oxygen, heat up to 70°C, and add in sequence Stir the glycerin and sodium hydroxide until they are completely dissolved, keep the temperature constant, and form a water phase.

[0042]In the state of nitrogen protection, start the high-speed emulsification and sh...

Embodiment 2

[0045] Get poppy seed oil 50g, tanshinone 10.5g, polyene phosphatidylcholine 10g, vitamin E 100mg, oleic acid 1g, sodium hydroxide 25mg, add water to 1000ml; Prepare by the same preparation process as Example 1. Aliquot and sterilize at 100°C / 30min.

Embodiment 3

[0047] Get poppy seed oil 100g, dihydrotanshinone 10.5g, polyene phosphatidylcholine 20g, vitamin E100mg, oleic acid 2g, glycerin 25g, sodium hydroxide 35mg, add water to 1000ml; Carry out by the preparation process identical with embodiment 1 Preparation, aliquoting. Sterilize at 121°C / 15min.

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Abstract

The invention discloses lipid microspheres comprising a lipid-soluble Salvia miltiorrhiza extract and Papaver somniferum seed oil, which are prepared by the steps of mixing the fat-soluble Salvia miltiorrhiza extract and Papaver somniferum seed oil, and making into an oil-in-water type lipid microsphere emulsion dispersion system by using the surface active nature of polyene phosphatidylcholine. The inventive lipid microspheres have certain apoptotic and inhibitory actions on H22 liver cancer cells; and can be used for preventing and treating hepatic injury.

Description

technical field [0001] The invention provides a lipid microsphere combined with salvia miltiorrhiza miltiorrhiza and poppy seed oil. The invention also discloses its preparation method and its medical use in the preparation of medicines for preventing and treating liver damage diseases, which belongs to the field of medicine preparation. . Background technique [0002] Poppy seed oil is the oil squeezed from the seedlings of the poppy plant (Papavei Somniferum L). Poppy seed oil is non-toxic and non-narcotic. It is composed of a small amount of saturated fatty acids and polyunsaturated fatty acids, and contains linolenic acid and arachidic acid that are easily absorbed by the human body. high. It is an essential fatty acid that cannot be synthesized in the human body. This fatty acid is absorbed and transformed into γ-linolenic acid by the human body, and finally produces prostaglandins, which participate in the regulation of various basic physiological processes of the h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/66A61K47/24A61P1/16
Inventor 陈曦侯文阁
Owner HEILONGJIANG BAOQINGLONG BIOTECH
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