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Cordycepin polysaccharide buccal tablet and preparation method thereof

A Cordyceps polysaccharide and tableting technology, applied in the field of bioengineering, can solve the problems of single dosage form, restricting the development process of polysaccharide products, limiting throat moisturizing and local anti-inflammatory effects, etc.

Active Publication Date: 2011-09-21
HEILONGJIANG XINYISHENG PHARMACY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In short, the Cordyceps polysaccharide product has a single dosage form and simple compatibility, which seriously restricts the development process of polysaccharide products
In addition, judging from the efficacy of buccal tablets produced at home and abroad, most of them are limited to throat moistening and local anti-inflammatory effects.

Method used

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  • Cordycepin polysaccharide buccal tablet and preparation method thereof
  • Cordycepin polysaccharide buccal tablet and preparation method thereof
  • Cordycepin polysaccharide buccal tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of Cordyceps polysaccharide lozenges

[0033] Combination of raw and auxiliary materials ① Cordyceps polysaccharide extract: Cordyceps polysaccharide extract that has been crushed and passed through a 100-mesh sieve, the polysaccharide content is greater than 30%; ② Luo Han Guo extract: mogroside ≥ 80%; ③ green tea extract, tea polyphenols ≥ 80%; ④ composite filler: spray-dried mannitol 200SD is the main filler, with an additional amount of citric acid (or menthol), 10% polyvinylpyrrolidone (PVP) ethanol solution, magnesium stearate, mannitol and aspen Batian, etc., in line with national food hygiene requirements.

[0034] The various raw materials produced are combined into a mixture according to the following weight percentages for the next step of production.

[0035]

[0036] Production process Cordyceps polysaccharide extract, Luo Han Guo extract, green tea extract, + filler → (add 95% ethanol) granulate → (pass 14 mesh nylon sieve) dry (5...

Embodiment 2

[0053] Example 2 Detection of Cordyceps polysaccharide in buccal tablets

[0054] The finished buccal tablets made from Combination 1, Combination 2 and Combination 3 were taken respectively to detect the polysaccharide content.

[0055] 1. Sample Processing

[0056] (1) Sample extraction: take 10 buccal tablets and grind them in a mortar, weigh 2.0 g of a solid sample that is uniformly mixed, add about 80 mL of water to a 100 mL volumetric flask, heat with boiling water for 2 hours, cool to room temperature and then supplement Add water to the mark, mix well, filter, discard the initial filtrate, and collect the remaining filtrate for precipitation of polysaccharides.

[0057] (2) Precipitate crude polysaccharide: Accurately draw 5.0mL of the final filtrate sample (or 5mL of liquid sample), put it in a 50mL centrifuge tube, add 20mL of absolute ethanol, mix for 5min, centrifuge at 3000r / min for 5min, and discard the supernatant liquid. Wash the residue with a few millilite...

Embodiment 3

[0061] Example 3 TLC (thin-layer chromatography) qualitative identification of mogroside V in buccal tablets

[0062] The finished buccal tablets made from Combination 1, Combination 2 and Combination 3 were used for qualitative identification of Hanfructoside V.

[0063] (1) TLC conditions

[0064] Use 0.5% sodium carboxymethyl cellulose solution as the adhesive to pave the silica gel G plate with a thickness of 0.3mm and activate it at 105°C for 30min. Using n-butanol-ethanol-water (8:2:3) as the developer, develop upward with a span of 11 cm, develop color with 10% sulfuric acid ethanol, and bake at 105°C until the spots are clear.

[0065] (2) Preparation of reference substance solution

[0066] Accurately weigh 10.0 mg of Mogro side V reference substance, and dilute it in a 10 mL volumetric flask with distilled water to make a 1.0 mg / mL solution.

[0067] (3) preparation of test solution

[0068] Preparation of the test solution: Accurately weigh the compound Cordycep...

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Abstract

The invention relates to a polysaccharide buccal and a preparation method thereof, wherein, the polysaccharide buccal comprises 50-70 percent of polysaccharide extract, 5-15 percent of fructus monordicae extract, 2-10 percent of green tea extract and 20-30 percent of complex filling agent; and the preparation method of invention is that: the polysaccharide extract, the fructus monordicae extract and the green tea extract are taken to respectively cross a 100-meshed sieve, then mixed after being added with the complex filling agent, the evenly mixed medical powders are put into a trough-shapedmixer, then the confected wetting agent is added and mixed, later, the evenly mixed soft materials are put into a oscillating granulator to cross a nylon sieve and then made into granules, the granules are then put into a vacuum drier for drying and sizing the granules, finally are pressed into tablets by a tablet machine after being mixed evenly. The buccal has reasonable composing prescription,equal active ingredients and unique flavor and is a health care food which is suitable for being taken by most people.

Description

technical field [0001] The invention relates to a lozenge in the technical field of bioengineering and a preparation method thereof, in particular to a cordyceps polysaccharide lozenge and a preparation method thereof. Background technique [0002] Cordyceps fungi are a large class of medicinal fungi, belonging to the fungus (Eumycota), Ascomycotina (Ascmycotina), Sclerotinia (Pyenomycetes), Sphaerides (Sphaerides), Ergotaceae (Clavicipiracese) , Cordyceps (Cordyceps). This genus has been reported more than 350 species, domestic discovery has more than 30 species, some species can be used as medicine, some species can not be used as medicine, and more have not been studied. Cordyceps militaris in Cordyceps (Cordyceps militaris) is a species that parasitizes on the nymphs of Noctuidae, etc. It is distributed all over the world. Xu Jiazhong collected and reported it in Jilin in the 1950s, so it is called: Northeast Cordyceps, Northern Cordyceps, referred to as Northern Cordyce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/82A61K9/20A61P11/04A61P37/02
Inventor 汪新周选围
Owner HEILONGJIANG XINYISHENG PHARMACY
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