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Preparation method of heavy metal and trace element mass control standard substance in radix salvia miltiorrhiza

A standard substance and heavy metal technology, applied in the preparation of test samples, testing pharmaceutical preparations, and material inspection products, etc., can solve the problems of inaccurate value transfer, restricting foreign trade of traditional Chinese medicine, and large measurement errors.

Inactive Publication Date: 2008-12-24
SHANGHAI INST OF MEASUREMENT & TESTING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no standard material for traditional Chinese medicine, including harmful heavy metals and trace elements in Danshen. In fact, the standard materials used in the detection of heavy metals and trace elements in traditional Chinese medicine are all heavy metals and trace elements in the water matrix. The difference in matrix effect leads to large measurement errors and inaccurate value transfer, which seriously restricts the foreign trade of Chinese medicine in my country

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0004] Example 1: First, according to the 2005 edition Chinese Pharmacopoeia appendix ΠA medicinal material sampling method, Salvia miltiorrhiza was sampled, washed with tap water and then cleaned with ultrapure water, dried naturally in the shade to about 80% weight loss, and dried in the shade. Dry at a temperature of 50-70°C, preferably 60°C, to constant weight, and the drying time is 2-6 hours, preferably 4 hours; then, use a traditional Chinese medicine grinder to crush the particle size of the salvia miltiorrhiza to 60 mesh; then , the particle size of Salvia miltiorrhiza was crushed to 1350 mesh with a jet mill; then, the crushed Salvia miltiorrhiza was sealed and packaged at 30 g / bottle; finally, sterilized by cobalt-60 gamma ray irradiation with a sterilization dose of 6 kGy .

Embodiment 2

[0005] Example 2: First, according to the 2005 edition Chinese Pharmacopoeia appendix ΠA medicinal material sampling method, Salvia miltiorrhiza was sampled, washed with tap water and then cleaned with ultrapure water, dried naturally in the shade to about 80% weight loss, and dried in the shade. Dry at a temperature of 50-70°C, preferably 60°C, to constant weight, and the drying time is 2-6 hours, preferably 4 hours; then, use a traditional Chinese medicine grinder to crush the particle size of the salvia miltiorrhiza to 80 mesh; then , the particle size of Salvia miltiorrhiza was crushed to 700 mesh with a jet mill; then, the crushed Salvia miltiorrhiza was sealed and packaged at 35 g / bottle; finally, sterilized by cobalt-60 gamma ray irradiation with a sterilization dose of 6 kGy .

Embodiment 3

[0006] Example 3: First, according to the 2005 edition Chinese Pharmacopoeia appendix ΠA medicinal material sampling method, Salvia miltiorrhiza was sampled, washed with tap water and then cleaned with ultrapure water, dried naturally in the shade to about 80% weight loss, and dried in the shade. Dry at a temperature of 50-70°C, preferably 60°C, to constant weight, and the drying time is 2-6 hours, preferably 4 hours; then, use a traditional Chinese medicine grinder to crush the particle size of the salvia miltiorrhiza to 70 mesh; then , use a jet mill to crush the particle size of Salvia miltiorrhiza to 1000 mesh; then, seal and pack the crushed Salvia miltiorrhiza in 40 g / bottle; finally, sterilize it by irradiating cobalt-60 gamma rays with a sterilization dose of 6 kGy .

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Abstract

The invention relates to the field of metrology and measurement standard quantity value transmission technique, in particular to a preparation method which is widely applied to the researching and monitoring on heavy metal and trace element quality control standard matter (standard sample) in salvia, comprising the steps as follows: a. fore processing; b. mechanical crushing; c. airflow crushing; d. sealing package; e. germicidal treatment. The invention provides a quantity value transmission way of the heavy metal and the trace element in the salvia, has outstanding effects on the correct evaluation of researching the detection method for the heavy metal and the trace element in the Chinese traditional medicine and the quality control of export Chinese traditional medicine, prompting the standardization of the Chinese traditional medicine, ensuring the quantity value traceability, breaking through the green barrier of the export of the Chinese traditional medicine, and developing the national industry, etc., simultaneously, the method makes up the blank of the salvia in the field of the heavy metal and the trace element standard matter, prompts the development of the national Chinese traditional medicine on the export trade, and reduces the trade collision after China joins in the WTO.

Description

technical field [0001] The invention relates to the technical field of measurement and test standard value transfer, in particular to a preparation method of a quality control standard substance (standard sample) widely used in research and monitoring of heavy metals and trace elements in Danshen. Background technique [0002] In recent years, with the changes in human dietary structure and the emergence of aging society, the incidence of cardiovascular diseases has been increasing year by year. Danshen plays an irreplaceable role in clinical treatment and prevention. The development of science and technology has made Danshen There are more and more uses, leading to a rapid increase in export demand, and trade frictions also increase. Especially after my country's accession to the WTO, in the international market, the field of traditional Chinese medicine is the only field in which China has completely independent intellectual property rights, but it is facing a severe situa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15G01N1/28
Inventor 王虎杨静崔启明陈黎明吴立敏吴蓉
Owner SHANGHAI INST OF MEASUREMENT & TESTING TECH
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