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Optimizing method for attenuation processing of Tripterygium wilfordii and related formulation

An optimization method, the technology of Tripterygium wilfordii, which is applied in the field of purification and identification, and extraction of natural medicines, can solve difficult problems and achieve the effects of simple operation, reduced toxicity and significant efficacy

Inactive Publication Date: 2008-12-17
杨更亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, the current research on the dosage form of Tripterygium wilfordii mainly focuses on increasing drug stability, solubility, and reducing side effects. However, it is very difficult to reduce the toxicity of the drug and improve or maintain the curative effect when developing new dosage forms.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 200g of Tripterygium wilfordii, soak it in concentrated hydrochloric acid, and place it in a -20°C refrigerator for 5 minutes. After taking it out, extract it with chloroform three times, 300ml each time, wash the extract with water until it is neutral, and then wash it with anhydrous Na 2 SO 4 After drying and concentrating under reduced pressure, 5.68 g of a concentrate was obtained to prepare a preparation. Add 20mL of water to dissolve, filter and add 2g of potassium sorbate to prepare decoction or mixture; or add hypromellose (HPMC) and mix well, dissolve citric acid in ethanol as wetting agent to make soft material, granulate and dry , whole grains, mixed with magnesium stearate, and pressed into tablets; or dried, ground and passed through a 400-mesh sieve, mixed with 10 mg of sucrose 40 mg, added 0.8 mg of stearic acid, filled into No. 5 empty capsules and sealed to prepare capsules agent; or add water, add simple syrup, add glycerin to aid dissolution, ...

Embodiment 2

[0023] Weigh 200 g of Tripterygium wilfordii, soak it in a hydrochloric acid solution with a pH of 6.0, and place it in a refrigerator at 4°C for 48 hours. After taking it out, extract it with chloroform three times, 300ml each time, wash the extract with water until it is neutral, and then wash it with anhydrous Na 2 SO 4 After drying and concentrating under reduced pressure, 5.37 g of a concentrate was obtained to prepare a preparation. The relevant preparation method is the same as in Example 1.

Embodiment 3

[0025] Weigh 200 g of Tripterygium wilfordii, soak it in a hydrochloric acid solution with a pH of 6.0, and place it at 50° C. for 48 hours. After taking it out, extract it with chloroform three times, 300ml each time, wash the extract with water until it is neutral, and then wash it with anhydrous Na 2 SO 4 After drying and concentrating under reduced pressure, 5.62 g of a concentrate was obtained to prepare a preparation. The relevant preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses two optimization methods for attenuated processing of tripterygium wilfordii and the relevant preparations thereof. The optimization method (1) is that under the optimized condition, the traditional Chinese medicine tripterygium wilfordii is processed with salt water (or processed with acid) and processed with the acid (or processed with the salt water), or acid solution containing chloride ion is used for attenuation; the optimization method (2) comprises the following steps: under the optimized condition, tripterygium wilfordii extract, or the further purified product of the tripterygium wilfordii extract, or tripterygium wilfordii preparation is processed with the salt water (or processed with the acid) and processed with the acid (or processed with the salt water), the detailed method is described in the specifications. The methods have the advantages that the relevant preparations of the tripterygium wilfordii with the relatively low toxicity are obtained by the optimization of processing method, the medicinal resources of herb, root and bark, stem leaf parts of the tripterygium wilfordii with strong toxicity are utilized better, and the curative effect of tripterygium wilfordii preparations is strengthened. The methods of the invention simultaneously have the advantages of simple operation, low cost and being easy for popularization. The relevant preparations of the invention are used for treating rheumatoid arthritis, chronic nephritis, hepatitis, thrombopenic purpura and various dermatoarthritis, and can be used for resisting generation, anti-tumor, resisting rejection in the body after organ transplantation, etc.

Description

technical field [0001] The invention relates to methods for extracting, purifying and identifying natural medicines, in particular to a method for modifying traditional Chinese medicine Tripterygium wilfordii and its extracts. Background technique [0002] Triptergium wilfordii generally refers to the genus Triptergium wilfordii in the Euonymus family. There are four kinds of plants in China, three of which are used as medicine, namely Triptergium wilfordii Hook.f., which is produced in Zhejiang, Anhui, Hunan, Fujian and other provinces, mainly in the Yangtze River Downstream areas; Kunming Mountain Begonia (T.hypoglaucum Hutch), produced in the Yangtze River Basin and Southwest; Northeast Tripterygium (T.regelii Spragnc et Takcda), also known as black vine, mainly produced in Northeast China and Japan. Tripterygium wilfordii was first recorded in "Shen Nong's Materia Medica", and it has been widely used clinically for many years to treat rheumatoid arthritis, chronic nephri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61P29/00A61P19/02A61P13/12A61P7/00A61P1/16A61K125/00A61K127/00A61K133/00
Inventor 杨更亮王利娟管立李保芝
Owner 杨更亮
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