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Medicament composition for curing cardiovascular and cerebrovascular diseases and method of preparing the same

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied in the field of pharmaceutical compositions for the treatment of cardiovascular and cerebrovascular diseases and its preparation. Effect of reducing the size of the infarct area and reducing the area

Inactive Publication Date: 2008-10-08
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the shortcomings of the existing traditional Chinese medicine preparations for treating cardiovascular and cerebrovascular diseases, such as large doses, active ingredients and unclear mechanisms of action, and to provide a drug with rapid curative effect and safety for treating cardiovascular and cerebrovascular diseases Compositions and methods for their preparation

Method used

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  • Medicament composition for curing cardiovascular and cerebrovascular diseases and method of preparing the same
  • Medicament composition for curing cardiovascular and cerebrovascular diseases and method of preparing the same
  • Medicament composition for curing cardiovascular and cerebrovascular diseases and method of preparing the same

Examples

Experimental program
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Effect test

Embodiment 1

[0080] Embodiment 1: the preparation of injection

[0081] Prescription: Ginsenoside-Rd 9.6g, Astragaloside IV 6.4g, Sodium Chloride 9g, 1,2-Propanediol 100ml, Water for Injection

[0082] Preparation: Prepare 1,2-propanediol into a 500ml aqueous solution, add sodium chloride to dissolve, then add ginsenoside-Rd and astragaloside IV, stir in a water bath at 60-70°C until completely dissolved, cool to room temperature, add injection Make up to 1000ml with water, mix well and filter with 0.22μm membrane filter. The filtrate is filled in separate bottles, sealed, and sterilized to obtain the product.

[0083] Usage and dosage: 1 time / day, 1-2 bottles / time.

Embodiment 2

[0084] Embodiment 2: the preparation of dropping pill

[0085] Prescription: ginsenoside Rd 16g, astragaloside IV 4g, polyethylene glycol 6000 37g

[0086] Preparation: Take polyethylene glycol 6000, put it in a container, heat it to 70-80°C, wait until it is completely melted, and when the temperature drops to about 50°C, add ginsenoside Rd and astragaloside IV to melt, and control the temperature at 40-50°C ℃, pour it into a dropping pill machine for dripping, drop into simethicone oil, and make 1000 dropping pills.

[0087] Usage and dosage: Oral, 1-3 times / day, 1-2 capsules / time.

Embodiment 3

[0088] Example 3: Preparation of Sublingual Tablets

[0089] Prescription: Ginsenoside Rb1 10g, Isastragloside I 4g, hydroxypropylmethylcellulose (E-50) 80g, hydroxypropylmethylcellulose (E-4M) 50g, hydroxypropylcellulose 20g, micronized silica gel 3g, magnesium stearate 7g

[0090] Preparation: Take ginsenoside Rd, astragaloside IV, hydroxypropyl methylcellulose (E-50), hydroxypropyl methylcellulose (E-4M), hydroxypropyl cellulose, micronized silica gel and magnesium stearate Mix evenly with the method of increasing in equal amounts, and directly compress into 1000 sublingual lozenges.

[0091] Dosage: Take orally, 1-2 times / day, 1-2 tablets / time.

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Abstract

The invention provides a medicine composition used for treating cardio-cerebrovascular and a preparing method thereof in order to overcome the defects of large dosage and indefinite mechanism of effective components of the existing Chinese medicine preparation used for treating the cardio-cerebrovascular. The medicine composition is made of medicine materials comprising the monomer compositions of ginsenoside and astragalus saponin and excipient and is prepared by conventional preparation technology. Compared with prior art, the medicine composition of the invention has definite components, reliable curative effect, small dosage and manageable quality, so the medicine composition can effectively treat the cardio-cerebrovascular.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations for treating cardiovascular and cerebrovascular diseases, in particular to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases have the characteristics of high morbidity, high disability, high mortality and high recurrence rate, and are the number one killer of human death and disability at present and in the next 20 years. According to epidemiological surveys, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities, and the incidence of cerebrovascular diseases worldwide is 140-200 people / 10 million population, the average death rate is 100 people / 100,000 population, while the number of deaths due to cardiovascular and cerebrovascular diseases ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/7048A61P9/00A61P9/10A61P25/00
Inventor 张观福
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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