Iron supplementary liposome iron and method of preparing the same

A technology for liposomes and iron supplements, applied in the field of biological sciences, can solve the problem of not finding iron supplements liposome iron, etc., and achieve the effects of reducing drug dosage, improving absorption efficiency and easy operation.

Inactive Publication Date: 2008-09-03
HEBEI NORMAL UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

Although liposomes have the above excellent properties as a drug carrier, no relevant reports about iron supplement liposomal iron have been found in the existing literature after searching

Method used

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  • Iron supplementary liposome iron and method of preparing the same
  • Iron supplementary liposome iron and method of preparing the same
  • Iron supplementary liposome iron and method of preparing the same

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Embodiment Construction

[0030] The following examples are used to illustrate the present invention.

[0031] The composition of iron supplement liposomal iron:

[0032] The mass ratio of heme iron and / or inorganic iron: cholesterol: lecithin is (0.1~200): (1~10): (10~100)

[0033] Preparation:

[0034]Weigh an appropriate amount of cholesterol and lecithin, the mass ratio of the two is (1-10): (10-100), add a certain amount of organic solvent ethanol, and after it is completely dissolved, place it in a 250ml ground-mouth pear-shaped flask. Then put the pear-shaped flask in a constant temperature water bath of 25~38℃, and use a rotary evaporator to volatilize the organic solvent under the conditions of rotation speed 80~140r / min and reduced pressure (the pressure is kept at 0.08~0.1MPa) to make phospholipids and other films form The material forms a uniform lipid film on the wall of the flask, and then fills the flask with N 2 120~200min to completely remove the solvent; meanwhile, weigh the heme iron acc...

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Abstract

The invention relates to a liposomal iron prepared as a novel iron-supplementing agent by a rotary film ultrasonic method. The liposomal iron is prepared from heme iron and / or inorganic iron, cholesterol and lecithin at a weight ratio of (0.1-200):(1-10):(10-100) by dispersing lecithin, and cholesterol ethanol solution into iron solution containing PBS under a specific condition. The inventive liposomal iron iron-supplementing agent has no toxicity or immunogenicity, has targeting ability, and can be used as pharmaceutical carrier. Clinically, the liposomal iron iron-supplementing agent can reduce drug dose, improve absorption efficiency, reduce toxicity, remarkably improve the solubility and stability of heme iron, and improve bioavailability. The rotary film ultrasonic method can obtain liposome with high encapsulation efficiency, can effectively remove organic (ethanol) residues, and has the advantages of easily controlled process conditions and simple operation.

Description

Technical field [0001] The invention relates to a new iron supplement, especially liposomal iron and a preparation method thereof, belonging to the technical field of biological sciences. Background technique [0002] Iron-deficiency anemia is currently one of the most common diseases in my country and internationally. There are many types of iron supplement drugs and nutrients. However, since the absorption mechanism of intestinal iron has not been clarified, people have developed many kinds of diseases without knowing the mechanism. Iron supplements are very blind and have poor effects. Some are very toxic, poor in taste and irritating to the digestive tract. With the understanding of the mechanism of intestinal iron absorption in recent years, we have learned about the mechanism of intestinal iron absorption and regulation pathways, providing a theoretical basis for the development of new iron supplements. Studies have shown that heme iron is a kind of biological iron. Compare...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K9/127A61K47/28A61K47/24A61P3/02A61K31/555
Inventor 常彦忠葛兰段相林
Owner HEBEI NORMAL UNIV
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