Thermostatic sustained release injection containing topoisomerase inhibitor and preparing method thereof

Abstract

A temperature control sustained release injection comprising topoisomerase inhibitor is composed of the topoisomerase inhibitor with an effective anti-cancer amount, an amphiphilic block copolymer, menstruum, and medicine release regulator with a fixed amount; wherein, the amphiphilic block copolymer consists of polyethylene glycol and polyester and an aqueous liquid of the amphiphilic block copolymer under a room temperature can change into a semi-solid or solid gel which can be absorbed by biodegradation and insoluble in water in a body of a hot blood animal; thereby being able to slowly release the Polyphosphate 3-Kinase inhibitor comprised in partial knub for a plurality of weeks to a plurality of months; an anti-cancer sustained release injection, being injected in the knub or in the surroundings of the knub or being arranged in a knub cavity after operation, can remarkably reduce the general reaction of the medicine, selectively enhance the curing effects of non operative treatments like chemotherapy and radiotherapy, and is used for curing the knub of different stages. The topoisomerase inhibitor is selected from self-hydroxy camptothecin, lartotecan, topotecan, irinotecan, etoposide, teniposid, podophyllotoxin, amrubicin, doxorubicin, esorubicin, pirarubicin and valrubicin.

Description

(1) Technical field [0001] The invention relates to a temperature-controlled slow-release injection containing a topoase inhibitor, which belongs to the technical field of medicines. Specifically, the invention relates to a slow-release gel preparation capable of stably releasing topoase inhibitors locally in solid tumors, mainly a slow-release gel injection. The slow-release gel preparation is an aqueous solution at room temperature, In animals, it can become a semi-solid or solid gel, so that the included topoase inhibitor can be slowly released locally in the tumor, from several days to several weeks. (2) Background technology [0002] Local application of chemotherapeutic drugs, especially local sustained release, has become the current research direction and focus of solid tumor chemotherapy. However, the current biodegradable sustained and controlled release preparations mostly use solid polymers such as polyglycolic acid, polylactic acid or their copolymers as sustai...

AI Technical Summary

Problems solved by technology

Therefore, in most cases, the final sustained-release formulations are mostly solid shapes (eg, microspheres, tablets, or rods), which require a more complicated implantation process and are prone to tissue trauma and even tumor cell seeding or dissemination

In addition, organic solvents or high-heat processes often lead to the degradation and denaturation of many anti-cancer active ingredients, and solid implants cannot effectively cover the irregular tumor cavity after tumor resection. relapse