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Medicine compounds of pericarp trichosanthis, longstamen onion bulb extract and preparing method thereof

A technology of extract and Trichosanthes peel, which is applied in the field of traditional Chinese medicine pharmaceuticals, can solve the problems of no clear quality control means, unfavorable long-term storage of aqueous solution, and the need for several grams or even tens of grams, so as to achieve safety without obvious side effects and reduce consumption The amount, the effect of reducing the efficacy of the drug

Inactive Publication Date: 2008-07-23
江苏吴中苏药医药开发有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Gualou Xiebai Decoction has not yet been developed as a drug, and it is used clinically as a decoction
There are many inconveniences in the use of traditional Chinese medicine: (1) Most traditional Chinese medicines are decocted in water, which requires special decoction tools. The operation is troublesome, the process is unstable, and the aqueous solution is not conducive to long-term storage. Seriously restrict the clinical use of
(2) Traditional Chinese medicines are taken in a large amount. After extraction by conventional water decoction, even if it is made into a preparation, several grams or even tens of grams are needed.
(3) Traditional Chinese medicine only identifies the authenticity of the source of the medicinal materials, but there is no clear control method for its quality, which makes it difficult to guarantee the quality of the medicinal materials and also affects the efficacy of the medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Put the Trichosanthes peel medicinal material in the extraction tank, add water and boil for extraction three times, each time the volume of water added is 10 times, 8 times, and 8 times the mass of the medicinal material, the first extraction is 3 hours, the second extraction is 2 hours, and the third extraction is 3 hours. Extract for 2 hours, combine the three extracts, filter with a sieve, place the filtrate in a vacuum distillation pot at 80°C and concentrate under reduced pressure to an appropriate amount (concentrate to 4000ml of medicinal solution per kg of crude drug), add 90-95% ethanol while it is hot , stir while adding, add to alcohol content and be 65% (according to ethanol specific gravity), leave standstill 36 hours, make it fully precipitate, filter supernatant, precipitate centrifugation, merge supernatant; Pressure reclaims ethanol, concentrates to 1ml reclaimed liquid and is equivalent to 2g crude drug, filters, and filtrate goes up 732 type cation ex...

Embodiment 2

[0043] Put the Trichosanthes barbatus medicinal material in an extraction tank, add 30% ethanol and heat and reflux to extract three times, and the volume of each solvent is 10 times, 8 times and 8 times of the mass of the medicinal material respectively. Heat and extract for the first time for 3 hours, extract for the second time for 2 hours, extract for the third time for 2 hours, combine the three extracts, filter with a screen, and place the filtrate in a vacuum distillation pot to concentrate under reduced pressure to an appropriate amount (concentrated crude drug per kg) to 1500ml liquid medicine), add 90-95% ethanol while it is hot, stir while adding, add until the alcohol content is 90% (according to the specific gravity of ethanol), let it stand for 48 hours, make it fully precipitate, and filter the supernatant Liquid, sediment centrifugation, combined supernatant; supernatant decompression recovery ethanol, concentrated to 1ml recovered liquid equivalent to 0.5g crud...

Embodiment 3

[0048] Put the Trichosanthes barbatus medicinal material in an extraction tank, add 95% ethanol and heat and reflux for extraction three times, and the solvent volume each time is 10 times, 8 times, and 8 times the mass of the medicinal material respectively. Heat extraction for 3 hours for the first time, 2 hours for the second extraction, and 2 hours for the third extraction, combine the three extracts, filter, decompress the supernatant to recover ethanol, concentrate until 1ml of recovered solution is equivalent to 1g of crude drug. The method of column adsorption and elution of the extract of Trichosanthes barbatus, the preparation of the extract of Trichosanthes barbas, the extraction of the medicinal solution of Xiebai, the adsorption and elution of the extract of Xiebai on the column, and the preparation method of the extract of Xiebai are the same as in Example 2.

[0049] The extract of the quince peel and the extract of the scallops are taken according to the weight ...

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Abstract

The invention discloses a medicine combination of snakegourd peel extract and allium macrostemon extract. The medicine combination is composed of 50-90 parts of snakegourd peel extract and 10-50 parts of allium macrostemon extract by weight; wherein, the total amino acid content in the snakegourd peel extract is not less than 50 percent, if calculated according to arginine, and the total saponin content in the allium macrostemon extract is not less than 50 percent, if calculated according to dioscin. The combination has stable quality, and high content of effective ingredients; the technique of the preparation method of the invention is stable, and has good reproduction quality. Proved by pharmacological tests, the combination has better protective effect on acute myocardial ischemia caused by rat hypophysin and canine myocardial ischemia due to coronary artery ligation. The medicine combination of the invention has promising application prospect in the respect of treating cardiovascular system diseases.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a medicinal composition of Trichosanthes bark and Allium scallions extracts for treating diseases of the cardiovascular system and a preparation method thereof. Background technique [0002] Coronary heart disease belongs to the category of "chest obstruction" and "heart palpitation" in traditional Chinese medicine. The syndromes of traditional Chinese medicine are stagnation of qi and blood stasis, depression of chest yang, endogenous phlegm turbidity, and blockage of heart vessels to cause disease. "Gualou Xiebai Decoction" is the first prescription of Zhang Zhongjing, a famous doctor in the Eastern Han Dynasty, in "Synopsis of the Golden Chamber", which treats "chest pain and shortness of breath" mainly. Symptoms, namely the current coronary heart disease angina pectoris. After thousands of years of clinical practice, "Gualou Xiebai Decoction" ...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 顾维沈晓兰楼凤昌曹庆先
Owner 江苏吴中苏药医药开发有限责任公司
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