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Bone plate with sustained-release antimicrobial peptide

The technology of bone plate and antibacterial peptide is applied in the field of slow release bone plate loaded with antibacterial peptide and its manufacturing field, which can solve the problems that antibiotics are difficult to achieve effective antibacterial concentration, induce bacterial resistance, difficult to traumatic osteomyelitis and anti-infective effect, etc. Strong anti-infective bacterial biofilm formation, inhibition of bacterial biofilm formation, and improved efficacy

Inactive Publication Date: 2011-07-27
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former, often due to local injury and blood circulation disruption, makes it difficult for the antibiotics in the systemic blood to reach an effective antibacterial concentration in the damaged area; the latter, although it can initially produce a high concentration of antibiotics in the local area, is often easily diluted and cannot maintain an effective concentration
Therefore, it is difficult to have an effective anti-infection effect on the formation and development of traumatic osteomyelitis.
Even with the application of polymethyl methacrylate (PMMA) local slow-release antibiotics proposed in recent years, there are still disadvantages such as inducing bacterial resistance, having to be removed as a foreign body, and having no effect on fixing the fracture.

Method used

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  • Bone plate with sustained-release antimicrobial peptide
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  • Bone plate with sustained-release antimicrobial peptide

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Carry the manufacture method of antimicrobial peptide slow-release bone plate, carry out as follows:

[0017] Step 1, pretreatment of the surface of the titanium metal bone plate. The titanium metal bone plate was ultrasonically cleaned with distilled water, acetone, 75% ethanol, and distilled water for 10 minutes each. After taking it out, it was washed with deionized water and placed in 18wt with a volume ratio of 1:1. %HCl and 48wt%H 2 SO 4 20 minutes in the formed acid solution, take it out and wash it with deionized water, then place it in 2M NaOH solution, heat it at 50°C for 12 hours, then wash it with deionized water, and then put it in a Maofu furnace to heat at 600°C 1 hour;

[0018] Step 2, pre-coating hydroxyapatite coating 2, put the titanium or titanium alloy bone plate treated in step 1 into a mixture of NaCl: 733.5mM; CaCl 2 .2H 2 O: 12.5mM; Na 2 HPO 4 .2H 2 O: 5mM; NaCO 3 : Add 5mM MgCl to the saturated bionic solution prepared at 21mM 2 .6H 2...

Embodiment 2

[0024] Carry the manufacture method of antimicrobial peptide slow-release bone plate, carry out as follows:

[0025] Step 1: Pretreatment of the surface of the titanium alloy bone plate. The titanium alloy bone plate was ultrasonically cleaned with distilled water, acetone, 75% ethanol, and distilled water for 15 minutes each. After taking it out, it was washed with deionized water and placed in 18wt with a volume ratio of 1:1. %HCl and 48wt%H 2 SO 4 In the acid solution formed for 30 minutes, take it out and wash it with deionized water, then place it in 8M NaOH solution, heat it at 80°C for 48 hours, then wash it with deionized water, and then put it in a Maofu furnace to heat at 600°C 2 hours;

[0026] Step 2, pre-coating hydroxyapatite coating 2, put the titanium or titanium alloy bone plate treated in step 1 into a mixture of NaCl: 733.5mM; CaCl 2 .2H 2 O: 12.5mM; Na 2HPO4.2H 2 O: 5mM; NaCO 3 : Add 10mM MgCl to the saturated bionic solution prepared at 21mM 2 .6H ...

Embodiment 3

[0032] Carry the manufacture method of antimicrobial peptide slow-release bone plate, carry out as follows:

[0033] Step 1, pretreatment of the surface of the titanium metal bone plate. The titanium metal bone plate was ultrasonically cleaned with distilled water, acetone, 75% ethanol, and distilled water for 15 minutes each. After taking it out, it was washed with deionized water and placed in 18wt with a volume ratio of 1:1. %HCl and 48wt%H 2 SO 4 25 minutes in the formed acid solution, take it out and wash it with deionized water, then place it in 6M NaOH solution, heat it at 60°C for 30 hours, then wash it with deionized water, and then put it in a Maofu furnace to heat at 600°C 1.5 hours;

[0034] Step 2, pre-coating hydroxyapatite coating 2, put the titanium or titanium alloy bone plate treated in step 1 into a mixture of NaCl: 733.5mM; CaCl 2 .2H 2 O: 12.5mM; Na 2 HPO4.2H 2 O: 5mM; NaCO 3 : Add 7mM MgCl to the saturated bionic solution prepared at 21mM 2 .6H 2...

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Abstract

The invention discloses a release bone plate with antibiotic peptide; the matrix is medical titanium or titanium alloy material; the surface of the matrix is coated with hydroxyapatite and other release materials, wherein, beta- alexin-1 to 3 or lactoferrin 1-11 are combined; the thickness of the release coating is 5 to 30Mu M. The biomimetic solution method and coating method in the application surface coating technology of antibiotic peptide are used to design to carry the antibiotic peptide through the hydroxyapatite and other release materials, research and prepare a release steel plate with irreplaceable roles and multi-functions, such as strong anti-infection, thus prohibiting the forming of the bacteria bio-film and phase I fracture curing, etc., so that the steel plate can early release the beta- alexin-1 to 3 or lactoferrin 1-11 from inside to outside, change the action way of traditional antibiotics essentially, solve the technical difficulty that the antibiotic peptide cannot bear high temperature for a long time, directly prohibit the formation and development of the bio-film, and obtain the curative effect of preventing relevant infection of fixtures.

Description

technical field [0001] The present invention belongs to surgical medical materials and a manufacturing method thereof, in particular, an antimicrobial peptide-loaded slow-release bone plate and a manufacturing method thereof. Background technique [0002] In daily life, the infection rate after open fracture surgery is 3-29%. In wartime firearm injuries, due to serious tissue damage and pollution, there are a large number of bacteria within 0.5cm around the ballistic trajectory, even if the bone and soft tissue are infected after debridement. The infection rate is still as high as 25% to 40%, and if internal fixation is used, the infection rate will increase by more than 30%. Therefore, traumatic osteomyelitis has not been well resolved. General traditional treatment methods: first use surgical methods such as thorough debridement or lesion removal to remove most of the bacteria; on this basis, use external fixation brackets to temporarily fix the fracture ends; apply large...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/34A61L27/06A61L27/54A61B17/80
Inventor 费军余洪俊王爱民赵传宏潘长江
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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