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Levulorotation carnitine calcium fumarate and its preparing method and use

A technology of calcium fumarate and L-carnitine, applied in the field of preparation of calcium L-carnitine fumarate and its preparation, nutritional supplement composition for calcium supplementation, pharmaceutical intermediates and food additives, can solve the problem of galactose two Acid does not have the problems of mass production and high price, and achieves strong and more functional nutritional and therapeutic effects, suitable for oral administration, and convenient for storage and transportation

Active Publication Date: 2008-07-02
リャオニンコンセプヌトラシーオーエルティーディー
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the double salt formed with calcium ions, so far, only L-carnitine calcium galactarate has been patented, but galactaric acid is not produced in large quantities in China, and the price is relatively expensive
However, the most commonly used L-carnitine fumarate has no reports of forming double salts with calcium.

Method used

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  • Levulorotation carnitine calcium fumarate and its preparing method and use
  • Levulorotation carnitine calcium fumarate and its preparing method and use
  • Levulorotation carnitine calcium fumarate and its preparing method and use

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Effect test

Embodiment 1

[0037] The preparation of embodiment one L-carnitine calcium fumarate (2: 2: 1)

[0038]

[0039] Add fumaric acid (11.6g, 0.1mol) into 200mL water and stir to dissolve, add calcium hydroxide (3.7g, 0.05mol) ground into fine powder twice every half hour, heat up to 70-90°C, and stir vigorously until The solution was clear and reacted for two hours, and the water was distilled off under reduced pressure. Add L-carnitine (16.12g, 0.1mol) and 200mL ethanol, react at 60-70°C for 3h, cool down to room temperature, freeze at -5-5°C for 2 hours, and suction filter to obtain L-carnitine calcium fumarate. Further drying was carried out to obtain 28 g of the product, with a yield of 95%.

[0040] The obtained L-carnitine calcium fumarate has good fluidity, and the powder is uniform, and more than 98% of the powder is less than 40 mesh. Good water solubility, the solubility is 1.8g / 100mL water. Expose for 24 hours at a relative humidity of 60±5% at 25°C, no agglomeration and sticki...

Embodiment 2

[0057] The preparation of embodiment two L-carnitine calcium fumarate (1: 2: 1)

[0058]

[0059] Dissolve fumaric acid (23.2 g, 0.2 mol) in 740 mL of water, add Ca(OH) 2 (7.4g, 0.1mol) was heated to 70°C, stirred vigorously until the solution was clear, reacted for two hours, distilled off the water under reduced pressure, and dried. Add the dry obtained solid into 200mL ethanol and stir evenly, add L-carnitine (16.12g, 0.1mol), react at 60-70°C for 3h, freeze at -5-5°C for 5 hours, and obtain L-carnitine fumar by suction filtration Calcium acid, and then dried to obtain 39.5g, yield 91.6%. The water solubility of the compound is less than 40 mesh powder, the water solubility is 3.5g / 100mL (cold water), and the calcium content is 9.28%.

[0060] The obtained L-carnitine calcium fumarate has good fluidity, and the powder is uniform, and more than 98% of the powder is less than 40 mesh. Good water solubility, the solubility is 3.5g / 100mL water. Expose for 24 hours at a r...

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Abstract

The invention relates to an L-carnitine calcium fumarate and a preparation method and usages thereof. The L-carnitine calcium fumarate is characterized by oral intake, stability and no-hygroscopicity, and has stronger and more functions of nutrition and treatment, compared with corresponding internal salt and good water solubility; the preparation method is: the calcium furmarate is dissolved in the water and added with calcic alkali for reaction with the temperature increasing to 70 to 90 DEG C for 2 to 8 hours and then water is evaporated by reducing pressure. The solid obtained by drying is added into ethanol and evenly mixed, with the L-carnitine added for reaction with the temperature at 60 to 70 DEG C for 1 to 6 hours, then the mixture is put into a refrigerator for refrigeration for 2 to 8 hours and the L-carnitine calcium fumarate is finally obtained by suction and filtration; the composition containing the L-carnitine calcium fumarate can be made into one or more excipients acceptable on pharmacology, particularly solid and liquid oral intake preparation, such as powdered drug, granules, tablets, capsules, oral liquid, etc., is preferred and the solid and liquid oral intake preparation can be used for food / nutrition additives for people, or feed additives for animals, including additives for calcium supplement.

Description

technical field [0001] The invention relates to a stable and non-hygroscopic pharmaceutically acceptable salt of L-carnitine, in particular to a kind of L-carnitine calcium fumarate and its preparation method and application, belonging to the preparation technology of pharmaceutical intermediates and food additives , suitable for preparing nutritional supplements for humans or animals, including a nutritional supplement composition for calcium supplementation. Background technique [0002] There have been many reports on the efficacy of L-carnitine. L-carnitine is an important food nutrition fortifier, which has been widely used in the food industry, such as infant milk powder, diet food, nutrition products for athletes and nutritional supplements for middle-aged and elderly people, as well as feed additives. In the industry, there are also medical effects. Cardiovascular disease, liver disease, kidney disease, hyperlipidemia, diabetes, neuromuscular disease, etc. can all be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/22C07C213/08A61K31/195A61P3/02A61P3/14A23L1/30
CPCC07C229/22C07C57/15A23V2002/00A23K20/105A23K20/147A23K20/24A23L33/175A61P1/16A61P3/02A61P3/06A61P3/10A61P3/14A61P9/00A61P9/10A61P13/12A61P21/00A61P25/00A23V2200/30A23V2200/326A23V2250/0612A23V2250/036A23V2250/1578
Inventor 袁学亮梅国庆卿笃清张薇薇陈泠
Owner リャオニンコンセプヌトラシーオーエルティーディー
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