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Medicine gradient zero level implantation controlled-release drug administration device and preparation thereof

A drug delivery device and drug technology, applied in the direction of medical formula, drug delivery, medical preparations of non-active ingredients, etc., can solve the problems of insufficient research and development, and achieve simple preparation process, good reproducibility, and high degree of automation Effect

Inactive Publication Date: 2008-07-02
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are reports on the preparation of implanted drug delivery systems using 3D printing technology, there is obviously insufficient research and development on how to take advantage of the technical advantages of 3DP and obtain the required controlled release characteristics through structural and local component differences.
This patent designs and prepares an implantable controlled-release drug delivery device with two-end release-resisting layer structure and intermediate drug distribution according to radial gradient. There are no related reports at home and abroad.

Method used

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  • Medicine gradient zero level implantation controlled-release drug administration device and preparation thereof
  • Medicine gradient zero level implantation controlled-release drug administration device and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: the deployment of layer powder and binder

[0035] Pass polylactic acid through a 200-mesh sieve, and take powder with a particle size of less than 74 μm for the top and bottom layers; weigh 2 grams of polylactic acid powder, dissolve it in 50 mL of acetone, and prepare a polylactic acid containing 4% (w / v) The top and bottom powder forming binders.

[0036] The raw material composition and content (by weight percentage) of intermediate mixing powder are as follows:

[0037] Polylactic acid 100 parts

[0038] Colloidal silicon dioxide 2 parts

[0039] Macrogol 6000 20 parts

[0040] Weigh 13 grams of the drug chloramphenicol and dissolve in 100 mL of acetone to prepare an intermediate mixed powder forming binder.

Embodiment 2

[0041] Example 2: Determining 3D printing forming parameters

[0042] Top and bottom surface spray forming parameters:

[0043] Layer interval time 3min

[0044] Powder layer thickness 200μm

[0045] Spraying rate [spraying drop volume (droplet quantity × droplet size) × spraying frequency] 0.4nL × 12kz

[0046] Spray times 3 times

[0047] Parameters of intermediate medicated mixed powder spraying:

[0048] Layer interval time 5min

[0049] Powder layer thickness 200μm

[0050] Spraying rate [spraying drop volume (droplet quantity × droplet size) × spraying frequency] 0.4nL × 12kz

[0051] Spraying times 5 times

Embodiment 3

[0052] Example 3: Preparation of Drug Gradient Drug Delivery Device

[0053] The operation and preparation are directly controlled by the computer terminal output instructions. First lay a layer of polylactic acid powder with a thickness of 200 μm, spray 4% polylactic acid acetone solution three times as a binder to form the bottom surface of the drug delivery device, and then the piston rod drives the powder bed of the workbench to descend as a whole to prepare a new layer of polylactic acid powder. pink.

[0054] The middle layer is a mixed powder of polylactic acid and other auxiliary materials, the thickness of the layer is 200 μm, and the acetone solution containing 13% chloramphenicol is used as a binder. times, repeat 30 layers.

[0055] Subsequently, another layer of polylactic acid powder with a thickness of 200 μm was spread, and 4% (w / v) polylactic acid acetone solution was sprayed three times as a binder to form the top surface of the drug delivery device. Final...

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Abstract

The invention relates to a drug gradient zero-grade implantation controlled release drug delivery device and the preparation method thereof; the drug delivery device takes the controlled release polymer as a frame, the top surface and the bottom surface are formed by bonding of the insoluble polymer, that is, the release resistant materials, and the middle drug is radially distributed according to the gradient. The axial two sides of the drug deliver system are sealed by the polymer, and then the drug is released radially and two-dimensionally; the radial drug concentration difference is obtained by the change of the times of printing and spraying the drug-carrying adhesives, the peripheral drug release area is big, the spraying times are less, and the drug concentration is low; the drug release area of the central area is small, the spraying times are more, and the drug concentration is high. The drug concentration takes the gradient distribution and the drug release rate is constant. The technique has simple preparation, high degree of automation and good reproducibility.

Description

technical field [0001] The invention belongs to the field of drug controlled-release preparations and preparations, in particular to a drug gradient zero-order implanted controlled-release drug delivery device and a preparation method thereof. Background technique [0002] The three-dimensional printing (Three Dimensional Print, 3DP) forming technology first proposed by MIT Sachs et al. (US patent, NO.5204055, 1993) is based on the concept of "layer-by-layer printing, layer-by-layer superposition" to prepare a special shape. or objects with complex internal structures. This technology uses powder as the material, the processing process is very flexible, the forming speed is fast, the operating cost is low and the reliability is high. It is one of the most viable new technologies in the rapid prototyping industry. The key equipment of this technology - 3D printer is generally composed of computer terminal, powder processing system (including powder feeding, layering and recy...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/34A61K47/10A61K47/32
Inventor 朱利民余灯广申夏夏
Owner DONGHUA UNIV
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