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Method of preparing bioavailability water-based magnetofluid

A biocompatibility and magnetic fluid technology, applied in the direction of magnetic liquid, medical preparations of non-active ingredients, inductance/transformer/magnet manufacturing, etc., can solve the problem of poor stability of magnetic liposomes and shell biocompatibility Unsatisfactory, large particle size of magnetic beads, etc., to achieve the effect of easy wide application, good biocompatibility, and small particle size

Inactive Publication Date: 2010-09-01
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the above materials, polymer magnetic beads have a large particle size and poor shell biocompatibility, and the stability of magnetic liposomes is not good, so it is difficult to apply clinically.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: get the ferric nitrate solution of 10ml 0.12mol / L and the ferrous sulfate solution of 10ml 0.08mol / L, mix and stir evenly, in 40 ℃ constant temperature water bath, add 1.6ml ammoniacal liquor (25%) rapidly, stir 15min , the temperature was raised to 60°C and the reaction was stopped for 5 minutes. Wash the generated black precipitate with distilled water until the upper liquid is neutral, and what is obtained is nano-Fe 3 o 4 . Add 16ml of water to the precipitate, and sonicate for 2 minutes to obtain a uniformly dispersed black solution, which is recorded as solution A; take 4ml of 0.17mol / L sodium gluconate aqueous solution, which is recorded as solution B. Add solution B to solution A, stir at 40°C for 2 hours to fully interact with each other, and sonicate for 2 minutes to finally obtain a stable water-based magnetic fluid. The particle size of the nanocomposite particles prepared by the method is 8.7nm, and the saturation magnetization is 35.3emu / g...

Embodiment 2

[0020] Embodiment 2: get the ferric nitrate solution of 10ml 0.18mol / L and the ferrous sulfate solution of 10ml 0.12mol / L, mix and stir evenly, in 40 ℃ constant temperature water baths, add 2.4ml ammoniacal liquor (25%) rapidly, stir 15min , the temperature was raised to 60°C and the reaction was stopped for 5 minutes. The resulting black precipitate was washed with distilled water until the upper liquid was neutral. Add 24ml of water to the precipitate, and sonicate for 2 minutes to obtain a uniformly dispersed black solution, which is recorded as solution A; take 6ml of 0.17mol / L sodium gluconate aqueous solution, which is recorded as solution B. Add solution B to solution A, stir at 40°C for 2 hours, and sonicate for 2 minutes to finally obtain a stable water-based magnetic fluid. The particle size of the nanocomposite particles prepared by the method is 10nm, and the saturation magnetization is 36.5emu / g.

Embodiment 3

[0021] Embodiment 3: get the ferric nitrate solution of 10ml 0.24mol / L and the ferrous sulfate solution of 10ml 0.16mol / L, mix and stir evenly, in 40 ℃ constant temperature water baths, add 3.2ml ammoniacal liquor (25%) rapidly, stir 15min , the temperature was raised to 60°C and the reaction was stopped for 5 minutes. The resulting black precipitate was washed with distilled water until the upper liquid was neutral. Add 32ml of water to the precipitate, and ultrasonicate for 2 minutes to obtain a uniformly dispersed black solution, which is recorded as solution A; take 8ml of 0.17mol / L sodium gluconate aqueous solution, which is recorded as solution B. Add solution B to solution A, stir at 40°C for 2 hours, and sonicate for 2 minutes to finally obtain a stable water-based magnetic fluid. The particle size of the nanocomposite particles prepared by the method is 12nm, and the saturation magnetization is 38emu / g.

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PUM

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Abstract

The invention relates to a biological compatible water-based magnetic fluid material and the preparation method thereof, and belongs to the fields of the material and the preparation technology thereof. In the invention, nanometer scale Fe3O4 particles are prepared by adopting a chemical coprecipitation method in common use and dispersed in water, the surface modification is performed to the nanometer scale Fe3O4 particles with gluconic acid sodium salt, and finally stable water-based magnetic fluid is obtained. The magnetic fluid prepared by adopting the method of the invention takes Fe3O4 as the magnetic material, the gluconic acid sodium salt as a coating layer, and water as a carrier, thus the magnetic fluid has good biological compatibility. During the preparation process, oxygen isnot required to be isolated, the particle diameter of the obtained Fe3O4 is small, and the distribution is narrow. In addition, the preparation method has the advantages that raw materials are easy to be obtained, and the method is simple and easy to be carried out and widely applied.

Description

technical field [0001] The invention relates to a biocompatible water-based magnetic fluid material and a preparation method thereof, belonging to the technical field of materials and preparation thereof. Background technique [0002] Ferrofluid is a kind of colloidal solution in which ferromagnetic or superparamagnetic nanoparticles are stably dispersed in carrier liquid by means of surfactants or surface modifiers. Under the action of an alternating magnetic field, this colloidal solution can rapidly convert magnetic energy into thermal energy due to relaxation loss. In recent years, researchers in the fields of medicine and materials science have used this unique property to develop a new tumor treatment technology-tumor magnetic hyperthermia technology, and it is gradually moving towards clinical application. [0003] At present, three kinds of magnetic materials, polymer magnetic beads, magnetic liposomes and biocompatible water-based magnetic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/44H01F41/02A61K47/00
Inventor 单永奎董健媛薛燕杨帆
Owner EAST CHINA NORMAL UNIV
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