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Silk fibroin and polyvinyl alcohol blending antibacterial nanometer fiber and its preparation method

A polyvinyl alcohol, silk fibroin technology, applied in the direction of cellulose/protein conjugated rayon, fiber processing, filament/thread forming, etc. The problem of high dissolution rate, to achieve the effect of good adsorption, improved mechanical properties, good compatibility characteristics

Inactive Publication Date: 2008-05-28
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mat obtained by this method has a high dissolution rate in contact with water, and does not have antibacterial properties, which limits its application in biomedical materials
[0006] At present, silk fibroin and polyvinyl alcohol blended nanofibers with antibacterial properties have not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put 0.1 kg of leftover raw silk (the by-product of cocoon reeling in the silk reeling factory) into 5 liters of sodium carbonate aqueous solution with a concentration of 0.5%, boil for 0.5 hour, repeat the treatment six times, and try to remove the sericin and silk around the silk as much as possible. residual oil to obtain pure silk fibroin.

[0027] The pure silk fibroin after natural drying is swollen with a mixed solvent of calcium chloride:ethanol:water with a molar ratio of 1:2:8 for 1 to 2 days, and then stirred and dissolved in a water bath at 75°C for 2 hours. After 3 days of dialysis with deionized water, centrifugation to remove impurities, and then natural drying to obtain a regenerated silk fibroin membrane. The regenerated silk film was dissolved in formic acid with a mass fraction of 13% in a water bath at 70°C. Polyvinyl alcohol with a degree of polymerization of 2400 was dissolved in deionized water at a mass fraction of 7% in a water bath at 82°C. Th...

Embodiment 2

[0032] First put 0.2 kg of leftover raw silk (by-product of cocoon reeling in silk reeling factory) into 10 liters of sodium carbonate aqueous solution with a concentration of 0.5%, boil for 0.5 hour, repeat the treatment six times, and try to remove the sericin and silk around the silk as much as possible. residual oil to obtain pure silk fibroin.

[0033] The pure silk fibroin after natural drying is swollen with a mixed solvent of calcium chloride:ethanol:water with a molar ratio of 1:2:8 for 1 to 2 days, and then stirred and dissolved in a water bath at 75°C for 3 hours. After 3 days of dialysis with deionized water, centrifugation to remove impurities, and then natural drying to obtain a regenerated silk fibroin membrane. The regenerated silk film was dissolved in trifluoroacetic acid with a mass fraction of 15% in a water bath at 70°C. Polyvinyl alcohol with a degree of polymerization of 1700 was dissolved in deionized water with a mass fraction of 8% in a water bath at...

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Abstract

The invention discloses a nano-fiber and process for preparation, the components of the nano-fiber are silk fibroin, Argentine simple substance particles and polyvinyl alcohol, the process for preparation is that: a, after natural silk is unglued, dissolved, purified and dried, regenerated silk fibroin is obtained; b, the regenerated silk fibroin is dissolved in acidizing fluid, and regenerated silk acid solution is obtained; c, after polyvinyl alcohol is dissolved, polyvinyl alcohol solution is obtained; d, the two solutions are mixed. e, Ag-type inorganic salt is added; f, silver electrode is used to do electrostatic spinning, and blend nano fiber felt is obtained; g, the blend nano fiber felt is thermally treated for 2-5 minutes at the temperature condition of 100-150 DEG C and is treated by the radiation of ultraviolet light for 3-5 hours, and blend antibacterial nano fiber of the silk fibroin and the polyvinyl alcohol is obtained. The mechanical property of the fiber is better than pure silk fibroin fiber, the biocompatibility is excellent, the fiber has an antibacterial property, the fiber is suitable for bio-medical materials, in particular to tissue engineering scaffold materials.

Description

technical field [0001] The invention relates to a nanofiber and a preparation method thereof, in particular to a nanoscale antibacterial fiber blended with regenerated silk fibroin and polyvinyl alcohol and a preparation method thereof, belonging to the technical field of nanoscale fiber preparation, and the prepared material can be widely used in the fields of biology and medicine. Background technique [0002] Silk is rich in sources in my country. It is mainly composed of silk fibroin and sericin. Silk fibroin is non-toxic, non-irritating, non-allergic, has good biocompatibility, and can be prepared into films, gels, microcapsules, etc. Due to its unique physical and chemical properties, silk fibroin materials are widely studied in the field of biomedical materials, such as immobilized enzyme materials, cell culture substrates, drug sustained release agents, artificial organs, etc. Due to structural changes during processing, regenerated silk fibroin materials are difficu...

Claims

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Application Information

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IPC IPC(8): D01F8/02D01F8/10D01F1/10D01D5/00
Inventor 戴礼兴顾卓
Owner SUZHOU UNIV
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