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Compound sodium acetate electrolyte injection and preparation method thereof

A technology of electrolyte injection and compound sodium acetate, which is applied in the direction of pharmaceutical formulations, active ingredients of anhydride/acid/halide, medical preparations containing active ingredients, etc., can solve problems such as imperfect clinical use, and achieve benefits for blood sugar and blood sugar levels. Balance fat metabolism, make up for damaged parts of the liver, and inhibit hyperalteration of fat and hypoglycemia

Inactive Publication Date: 2010-05-19
CHINA OTSUKA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since most of the currently used clinically are lactated Ringer's solution, sugar-free Ringer's solution and acetic acid Ringer's solution with 5% glucose, there are imperfections in clinical use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: prepare compound sodium acetate electrolyte injection 250mL, 1000 bags:

[0038] Preparation prescription:

[0039]Sodium chloride (NaCl) 1.5925kg

[0040] Potassium chloride (KCl) 0.0745kg

[0041] Calcium gluconate (C 12 h 22 CaO 14 ·H 2 O) 0.16825kg

[0042] Magnesium Chloride (MgCl 2 ·6H 2 O) 0.05075kg

[0043] Sodium acetate (CH 3 COONa·3H 2 O) 0.8505kg

[0044] Sodium citrate (C 6 h 5 Na 3 o 7 2H 2 O) 0.147kg

[0045] Glucose (C 6 h 12 o 6 ) 2.5kg

[0046] Add water for injection to 250L

[0047] Preparation:

[0048] 1. It is prepared by using a stainless steel batching tank with a stirring paddle. First, add a pre-prepared amount of 80% water for injection. The water temperature is controlled at 40-45°C. Add sodium chloride, potassium chloride, magnesium chloride, and calcium gluconate in sequence according to the prescription amount (pre-used 80-90℃ water for injection), glucose, sodium acetate, sodium citrate, to dissolve,...

Embodiment 2

[0053] Embodiment 2: pharmacological action effect:

[0054] 1. Maintain the dynamic effect of circulation

[0055] Make a rabbit model of massive hemorrhage, make it lose 30% of the total blood volume rapidly, and quickly infuse 60mL / kg of this product about 3 times the amount of blood loss through the ear vein within 1 hour (the blood volume of the rabbit is generally 200ml, according to the body weight of 3kg A comparative study was carried out with Ringer's solution and 5% glucose plus lactate Ringer's solution on the maintenance effect of animal model's circulatory dynamics. It was found that the blood pressure, heart rate, and blood flow of the two groups all decreased after the end of blood removal, but they all recovered after infusion of this product, and the blood pressure and heart rate were well maintained thereafter.

[0056] 1. Serum magnesium maintenance and cashier improvement effect

[0057] Create a rabbit model of surgical injury (opening the abdomen to ex...

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PUM

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Abstract

The utility model relates to the technical field of chemical, in particular to a compound electrolyte injection of sodium acetate and process for preparation, wherein the compound electrolyte injection of sodium acetate takes natrium chloride, potassium chloride, calcium gluconate, magnesium chloride, sodium acetate, sodium citrate and glucose as raw materials. The compound electrolyte injection of sodium acetate of the invention is called sodium acetate equilibrium liquid because pH, osmotic pressure and molar concentration containing various particles are approximate to extra cellular fluidof human body. The invention is used to treat shock caused by oligemia of circulating blood and reduction of tissue fluid caused by operation, trauma, scald and profuse bleeding, to replenish and adjust the extra cellular fluid, to correct metabolic acidosis and to substitute partial blood transfusion as a crystalloid blood volume extended dose. The invention has the advantages of doing effectively organ perfusion, maintaining circularity stable, replenishing electrolyte, improving hyponatremia during shock, preventing and correcting acidosis.

Description

technical field [0001] The present invention relates to the technical field of chemical drugs, in particular to a compound sodium acetate electrolyte injection made from sodium chloride, potassium chloride, calcium gluconate, magnesium chloride, sodium acetate, sodium citrate and glucose as raw materials and its preparation method. Background technique [0002] Currently clinically used for extracellular fluid supplementation are: lactated Ringer's solution (with no sugar added and 5% glucose added), and acetate Ringer's solution (with no sugar added and 5% glucose added), among which the most used Lactated Ringer's solution is widely used, but a large amount of this type of electrolytic infusion can increase the lactic acid value in the blood. Lactic acid is mainly metabolized in the liver. When the liver function is low, it can lead to lactic acid metabolism disorders, especially in the case of surgical injury and hemorrhagic shock. Under normal conditions, the peripheral...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61P3/12A61K31/19A61K31/194A61K31/7004
Inventor 苗岩黄越王宁朱军夏焱
Owner CHINA OTSUKA PHARM CO LTD
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