Method and device for decreasing contamination

A technology of equipment, diagnostic equipment, applied in the field of clean rooms

Inactive Publication Date: 2008-03-05
PULMATRIX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These contaminants can create "fatal flaws" in tiny circuits

Method used

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  • Method and device for decreasing contamination
  • Method and device for decreasing contamination
  • Method and device for decreasing contamination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Example 1: In vitro simulation

[0092] The simulated cough machine system was designed similarly as described by King Am J. Respir. Crit. Care Med. 156(1):173-7 (1997). Construct an air-tight 6.5 liter Plexiglas tank with additional digital pressure measuring instrument and pressure relief valve as the capacitive function of the lungs. The tank is pressurized and a compressed air cylinder with regulator and air filter is connected to the inlet. At the inlet of the tank, an Asco two-way normal closed solenoid valve (8210G94) with sufficient Cv flow coefficient was connected for gas release. Reinforced solenoid valve with typical 120V, 60Hz light switch wire. The outlet port connected to the solenoid valve is a Fleisch no. 4 pneumotachometer, which creates the required Poiseuille flow detection "cough" profile. The outlet of the Fleisch tube was connected to the 1 / 4'' NPT inlet to the model trachea. The Validyne DP45-14 Differential Pressure Transducer measures the p...

Embodiment 2

[0095] These in vitro results show that application of saline to the mucus layer resulted in fragmentation with a substantial increase in particle size, possibly due to increased surface tension. As shown by the in vivo results, large size droplets were less able to exit the oral cavity. Therefore, the solution was administered to significantly reduce the amount of exhaled particles. Example 2: Reduction of Exhaled Airborne Particulates in Human Studies

[0096] A proof of concept study of exhaled aerosol particle generation was performed using 12 healthy individuals. The objectives of the study were (1) to determine the properties (size distribution and number) of exhaled bioaerosols; (2) to demonstrate the utility of the device sensitive enough to correctly count exhaled particles; (3) to estimate baseline counts of exhaled particles from healthy lungs; and (4) measuring the effect of two exogenously administered treatment sprays on inhibition of exhaled particle counts. ...

Embodiment 3

[0103] Example 3: Large animal studies

[0104]Seven Holstein steers were anesthetized, intubated and screened, and the baseline particle emission was measured by optical laser counting. Animals were then either untreated (sham) or treated with one of three doses (1.8 minutes, 6.0 minutes or 12 minutes) via a saline aerosolized spray. In the case of sham dosing, animals were treated in the same manner as they were dosed with isotonic saline solution. One animal was dosed daily and by random nebulizer throughout the exposure period (see Table 3 for dosing schedule). Each selected animal received all doses during the study. Exhaled particle counts were monitored for 180 minutes at discrete time points (0, 15, 30, 45, 60, 90, 120) after each dose was administered.

[0105] The exposure matrix for the animals used in this study can be found in Table 3. During the 57-day dosing period, there was an interval of at least 7 days between dosing. During the dosing period, each anim...

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Abstract

Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device ( 10 ) contains a mouthpiece ( 12 ), a filter ( 14 ), a low resistance one-way valve ( 16 ), a particle counter ( 20 ) and a computer ( 30 ). Optionally, the device also contains a gas flow meter ( 22 ). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as ''over producers'', ''super-producers'', or ''superspreaders''). Formulations to reduce particle production are also described herein. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. When applied to mucosal lining fluids, the formulation alters the physical properties such as the gel characteristics at the air/liquid interface, surface elasticity, surface viscosity, surface tension and bulk viscoelasticity of the mucosal lining. The formulation is administered in an effective amount to minimize ambient contamination due to particle formation during breathing, coughing, sneezing, or talking, which is particularly important in cleanroom applications. In one embodiment, the formulation for administration is a non-surfactant solution. In one embodiment, the formulations are conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment. Preferably the formulation is administered in the form of an aerosol.

Description

【Technical field】 [0001] The present invention is in the field of methods, formulations and apparatus for reducing particle emissions and contamination in various environments, and in particular for use in cleanrooms. 【Background technique】 [0002] A cleanroom is a controlled environment in which a product is manufactured. A clean room is a space where the concentration of airborne particles is controlled within a specific range. The reduction of sub-micron airborne pollution is a regulatory process. These contaminations can be generated by people, processes, facilities and equipment. These pollutants must be continuously removed from the air. The degree to which particles need to be removed depends on the desired criteria. The most commonly used standard is Federal Standard 209E. 209E is a document for establishing air cleanliness standard classification for the level of airborne particles in the clean room or clean zone (clean zone). Follow strict rules and procedur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/097G01N33/497G01N15/02
Inventor D·A·爱德华M·J·加布里埃尔森R·W·克拉克W·H·德哈安M·F·布朗德J·C－W·曼
Owner PULMATRIX
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