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Use of arctigenin in the preparation of medicament for treating and preventing chronic renal failure and kidney fibrosis

A technology of arctigenin and arctigenin, which is applied in the direction of drug combination, pharmaceutical formula, organic active ingredients, etc.

Inactive Publication Date: 2008-03-05
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pharmacological effects of arctigenin in the preparation of treatment or prevention of acute and chronic renal failure and renal fibrosis have not been reported. and renal fibrosis drug application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0010] The preparation of preparation example 1 arctigenin

[0011] Arctiin was purchased from Shanghai Yousi Biotechnology Co., Ltd. as white needle-like crystals with a purity of >98%. Helicase is a product of Shanghai Yuanju Biotechnology Co., Ltd. (batch number: 030510).

[0012] Arctiin 20g, add water for injection 1000ml, boil to completely dissolve arctiin. Cool to room temperature, add sterilized water to 1000ml, adjust the pH value to 5.0 with 1N hydrochloric acid, add 4g of helicase, stir to dissolve completely. Incubate in a 37°C water bath shaker for 24 hours. Add 8 times the volume of methanol, stir evenly, let stand overnight, filter through a 0.45 microporous membrane, evaporate the filtrate to dryness under reduced pressure, dissolve the residue in 1 L of chloroform, take the chloroform solution, add anhydrous sodium sulfate for dehydration, filter, and evaporate under reduced pressure dry (total aglycons). Take the total aglycone with silica gel (200-300 m...

preparation example 2

[0013] The preparation of preparation example 2 arctigenin

[0014] Arctiin was purchased from Shanghai Yousi Biotechnology Co., Ltd. as white needle-like crystals with a purity of >98%. Laetrile is a self-made sample.

[0015] Arctiin 20g, add water for injection 1000ml, boil to completely dissolve arctiin. Cool to room temperature, add sterilized water to 1000ml, adjust the pH value to 5.0 with 1N hydrochloric acid, add 4g of amygdalin, and stir to dissolve it completely. Incubate in a 37°C water bath for 48 hours. Extract twice with 5 times dichloromethane, combine the extracts, recover dichloromethane under reduced pressure at 70°C, separate the residue on a silica gel column, and elute with dichloromethane and dichloromethane-ethyl acetate (5:4) successively , HPLC detection of the outflow of arctigenin in the eluent, the effluent containing arctigenin was combined, concentrated under reduced pressure at 70°C to an appropriate volume, left at low temperature overnight,...

preparation example 3

[0016] The preparation of preparation example 3 arctigenin tablet

[0017] Weigh 40.0g of arctigenin, 85.0g of powdered sugar, 40.0g of lactose and 23.0g of sodium carboxymethyl starch, mix well and pass through a 100-mesh sieve, add 3% PVP K30 Appropriate amount of water solution to prepare soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, granulate with 18-mesh sieve, add 2.0g of magnesium stearate, mix evenly and compress into tablets, about 200mg per tablet, to obtain.

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PUM

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Abstract

The present invention is use of arctigenin in preparing medicine for preventing and treating chronic kidney failure and kidney fibrosis. The present invention also provides medicine composition with arctigenin as active component for preventing and treating chronic kidney failure and kidney fibrosis. When the medicine composition is applied in preventing and treating chronic kidney failure and kidney fibrosis, the injection has dosage of 30mg-1000 mg, preferably 30-500 mg, and the orally taken dosage is 50-2000 mg, preferably 50-800 mg.

Description

technical field [0001] The invention relates to the use of arctigenin in the preparation of medicines for treating or preventing chronic renal failure and renal fibrosis. Background technique [0002] Arctigenin is an active ingredient extracted from the traditional Chinese medicine Arctium chinensis, and can also be prepared by hydrolysis of arctiin. Burdock is a plant of the genus Arctium of the Compositae family, and is a traditional medicinal plant. As a traditional Chinese medicine, its seeds have the functions of dispelling wind and dissipating heat, clearing the lungs and clearing rashes, detoxifying the throat, smoothing the intestines and defecating. Its stems and leaves are also widely used among the people. However, the pharmacological effects of arctigenin in the preparation of treatment or prevention of acute and chronic renal failure and renal fibrosis have not been reported. And the application in the medicine of renal fibrosis. Invention content: [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P13/12
Inventor 蒋王林曲桂武岳喜典马福禄谢飞霞
Owner SHANDONG LUYE PHARMA CO LTD
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