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Anticoccidiosis pharmaceutical composition and method of preparing the same

A composition and anti-coccidial technology, applied in the directions of drug combinations, anti-infective drugs, pharmaceutical formulations, etc., can solve the problems of weakening and disappearing after two days, obvious adverse pharmacological effects, and high consumption of organic solvents, and can improve the health of the body. Resistance, improved bioavailability, wide range of effects

Inactive Publication Date: 2008-02-27
华云芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug has short duration of drug efficacy, poor drug dispersibility, and low bioavailability; traditional preparations use a lot of organic solvents, which are irritating and have obvious adverse pharmacological effects. Moreover, as long as the drug is stopped for one day, the anticoccidial effect It will obviously weaken and disappear after two days. In order to control the outbreak of coccidia, continuous medication is required, and drug resistance may also develop after continuous medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The anticoccidial pharmaceutical composition, its constituents and weight percentages are respectively:

[0028] Diclazuril 10% Vitamin K3 0.3%

[0029] Shigella net 0.8% DMF 30%

[0030] Tween-80 3% Ethanol 2%

[0031] Purified water 53.9%.

[0032] The steps of the preparation method of the anticoccidial pharmaceutical composition are:

[0033] (1). Fully mix diclazuril, vitamin K3, and dysentery net according to the weight ratio to form a drug mixture;

[0034] (2). Add auxiliary materials in the drug mixture according to the weight ratio, that is, add DMF, Tween-80, and ethanol respectively according to the weight ratio and stir evenly;

[0035] (3). Purified water is added according to the proportion, and the pH value is adjusted to 8 to obtain the finished product of anticoccidial pharmaceutical composition.

Embodiment 2

[0037] The anticoccidial pharmaceutical composition, its constituents and weight percentages are respectively:

[0038] Diclazuril 5% Vitamin K3 0.5%

[0039] Dysentery Net 1.2% DMF 20%

[0040] Tween-80 5% Ethanol 5%

[0041] Purified water 63.3%.

[0042] The steps of the preparation method of the anticoccidial pharmaceutical composition are:

[0043] (1). Fully mix diclazuril, vitamin K3, and dysentery net according to the weight ratio to form a drug mixture;

[0044] (2). Add auxiliary materials in the drug mixture according to the weight ratio, that is, add DMF, Tween-80, and ethanol respectively according to the weight ratio and stir evenly;

[0045] (3). Purified water is added according to the proportion, and the pH value is adjusted to 7 to obtain the finished product of anticoccidial pharmaceutical composition.

Embodiment 3

[0047] The anticoccidial pharmaceutical composition, its constituents and weight percentages are respectively:

[0048] Diclazuril 15% Vitamin K3 0.1%

[0049] Shigella net 0.4% DMF 40%

[0050] Tween-80 2% Ethanol 4%

[0051] Purified water 38.5%.

[0052] The steps of the preparation method of the anticoccidial pharmaceutical composition are:

[0053] (1). Fully mix diclazuril, vitamin K3, and dysentery net according to the weight ratio to form a drug mixture;

[0054] (2). Add auxiliary materials in the drug mixture according to the weight ratio, that is, add DMF, Tween-80, and ethanol respectively according to the weight ratio and stir evenly;

[0055] (3). Purified water is added according to the proportion, and the pH value is adjusted to 9 to obtain the finished product of anticoccidial pharmaceutical composition.

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PUM

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Abstract

The invention relates to a coccidiostat composition and making method in medicinal composition field, which comprises the following parts: 5-15% diclazuril, 0. 1-1% vitamin K3, 0. 5-2% mequindox and 35-45% findings to add purified water to 100%. The invention is characterized by the following: adopting modern micro emulsion technology to produce; improving bioavailability of diclazuril to a great extent; extending releasing drug time with good dispersity and stable thermodynamic property and facilitating to absorb because of low viscosity; solving faults of strong irritation and conspicuously bad medicinal crop of overusing organic solvent drug of traditional agent; improving body's resisting power to achieve expecting treating effect. The invention can be used for diseases raised through all kinds of coccidian because of low toxicity and high efficient, which can be water-based drinking and used conveniently.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, in particular to an anticoccidial pharmaceutical composition and a preparation method thereof. Background technique [0002] Coccidia is one of the most common parasites in the aquaculture industry. It often parasitizes the epithelium of the intestinal mucosa, causing slow growth, loss of appetite, dysplasia, diarrhea or bloody dysentery, and can lead to dehydration and weight loss. Death, livestock, poultry, pets, special animals, etc. can be infected, easy to re-infect and difficult to remove. At the same time, parasitic coccidia can also damage the intestinal mucosal tissue and be easily attacked by pathogenic bacteria in the intestinal tract, resulting in secondary bacterial enteritis, resulting in accelerated death of sick animals, increasing the mortality of sick animals, and bringing great harm to the breeding industry. Huge economic loss. [0003] Diclazuril is currently one o...

Claims

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Application Information

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IPC IPC(8): A61K31/53A61K47/34A61P33/02A61K31/498A61K31/122A61K47/26
Inventor 张兴龙华云芳
Owner 华云芳
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