Liposome artificial tear eye drops

A technology of artificial tears and eye drops, applied in liposome delivery, medical preparations of non-active ingredients, inorganic active ingredients, etc., can solve the problem of active ingredients replenishing water and vitamins, achieve long retention time and convenient use , the effect of stable quality

Inactive Publication Date: 2008-01-02
孙勐
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] The product "Liposome Eyelid Spray-trade name Liyanshu (health product)" produced by Tong Ren Tang Company uses liposome technology, but it can only be sprayed on the eyelids and cannot be dripped into the eyes, and the active ingredients cannot pass through the eyelids Penetrates into the eyes to replenish ingredients such as moisture and vitamins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Prescription: 1000ml liposomal artificial tear eye drops

[0067] Soy Lecithin 8.90g

[0068] Cholesterol 1.10g

[0069] Vitamin E (antioxidant) 0.05g

[0070] Preparation of hydration solution: 1000ml

[0071] Sodium bicarbonate 0.20g

[0072]Sodium chloride 9.00g

[0073] Glucose 1.00g

[0074] Potassium chloride 0.14g

[0075]

[0076] 1000ml

[0077] pH value: 5.0~7.0

[0078] The preparation method is as follows:

[0079] 1. Weigh the prescription amount of soybean lecithin, cholesterol and vitamin E, and dissolve them with chloroform or absolute ethanol or ether or petroleum ether.

[0080] 2. Put the lipid solution on a thin film evaporator, and remove the organic solvent under reduced pressure to obtain a lipid film.

[0081] 3. Prepare the hydration solution according to the prescription, sterilize and filter for later use.

[0082] 4. Pour solution 3 into the phospholipid membrane, and af...

Embodiment 2

[0085] Prescription: 1000ml liposomal artificial tear eye drops

[0086] Soy Lecithin 8.25g

[0087] Cholesterol 1.75g

[0088] Vitamin E (antioxidant) 0.05g

[0089] Preparation of hydration solution: 1000ml

[0090] Sodium bicarbonate 0.20g

[0091] Sodium chloride 9.00g

[0092] Glucose 1.00g

[0093] Potassium chloride 0.14g

[0094] Menthol 10mg

[0095] PVP 20mg

[0096]

[0097] 1000ml

[0098] pH value: 5.0~7.0

[0099] The preparation method is the same as in Example 1.

Embodiment 3

[0101] Prescription: 1000ml liposomal artificial tear eye drops

[0102] Soy Lecithin 7.52g

[0103] Cholesterol 2.48g

[0104] Vitamin E (antioxidant) 0.05g

[0105] Preparation of hydration solution: 1000ml

[0106] Sodium bicarbonate 0.20g

[0107] Sodium chloride 9.00g

[0108] Glucose 1.00g

[0109] Potassium chloride 0.14g

[0110] HPMC 250mg

[0111]

[0112] 1000ml

[0113] pH value: 5.0~7.0

[0114] The preparation method is the same as in Example 1.

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Abstract

The invention relates to an artificial eye tear drop of liposome for preventing and treating dry eye disease and eye fatigue, which comprises soybean lecithin, cholesterin, anti-oxidizing agent and artificial tear hydrated liquid, whose constituents include sodium hydrogen carbonate, sodium chloride, glucose, potassium chloride, water, or one or more auxiliary compositions of mint, PVP and HPMC.

Description

Technical field: [0001] The invention relates to an artificial tear eye drop containing lipid component prepared by liposome. For the prevention and treatment of dry eye disease and eye fatigue. Background technique: [0002] The main cause of dry eye is due to the reduction in the number of eye blinks. According to statistics, the normal number of human eye blinks is 15 times per minute, while it is only 4 to 5 times when operating a computer, and 2 to 3 times when driving a car. If the number of blinks is reduced by 75%, the secretion of tears will be significantly reduced. When the cornea is exposed to air for longer than the break-up time of the tear film, a complete tear film cannot be formed, resulting in dry eye syndrome. [0003] Other physiological reasons such as advanced age, lack of sleep, and mental stress can also cause a decline in tear quality. [0004] Ophthalmological studies have found that the tear film is composed of three distinct separable membranes...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/127A61K47/24A61P27/04A61K33/00A61K31/045A61K31/7004A61K31/717
Inventor 孙猛史雪燕孙仁俊
Owner 孙勐
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