Inclusion compound of higher fatty alcohol and its prepn
A high-level aliphatic alcohol and clathrate technology, which is applied in the direction of non-active ingredients of polymer compounds, food preparation, active ingredients of hydroxyl compounds, etc., can solve the problem of cyclodextrin inclusion complex reports and pharmacology of octacosanol that have not yet been found. The effect is not easy to exert, poor absorption in the body, etc., to achieve the effect of improving bioavailability, improving dissolution mechanism, and increasing surface area
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Embodiment 1
[0025] Example 1 β-CD is preparation of octacosanol clathrate of clathrate material
[0026] This example examines the preparation of octacosanol clathrates in which β-CD is clathrate material. Dissolve octacosanol in a small amount of ethanol, weigh an appropriate amount of β-CD according to the mass ratio of 1:1, 1:5, 1:10, 1:20, and 1:30, dissolve it in water, and After the start, slowly add the ethanol solution of octacosanol to the aqueous solution of cyclodextrin, ultrasonicate for 30 minutes, freeze-dry in vacuum, grind it finely, and pass through a 60-100 mesh sieve to obtain the octacosanol clathrate. At the same time, a blank experiment was carried out, and the dissolution rate of octacosanol in artificial gastric juice, distilled water, and phosphate was detected according to the method described in the instructions. The results are shown in Table 1.
[0027]
[0028] This example shows that the preparation of octacosanol β-CD inclusion compound by ultras...
Embodiment 2
[0029] Example 2 Preparation of octacosanol β-CD inclusion compound by different methods
[0030] This example investigates the preparation of octacosanol β-CD inclusion compound by different preparation methods. Mix octacosanol β-CD with β-CD at a mass ratio of 80% by mass, and prepare octacosanol β-CD according to different preparation methods such as saturated solution method, ultrasonic method and grinding method CD clathrate. At the same time, a blank experiment was carried out, and the dissolution rate of octacosanol in artificial gastric juice, distilled water, and phosphate was detected according to the method described in the instructions. The results are shown in Table 2.
[0031] Preparation
[0032] This example shows that the ultrasonic method is slightly better than the other three methods, and the ultrasonic method is preferred in this case. This example also shows that octacosanol in the β-CD inclusion compound prepared by the three methods has a g...
Embodiment 3
[0033] Example 3 Preparation of Higher Fatty Alcohol Inclusion Compounds Using Hydroxypropyl-β-CD as Inclusion Materials
[0034] This example examines the preparation of octacosanol inclusion compound with hydroxypropyl-β-CD as the inclusion material. Dissolve octacosanol with 80% higher fatty alcohol in a small amount of ethanol, and weigh hydroxyprene in proportions of 1:1, 1:5, 1:10, 1:20, 1:30 An appropriate amount of base-β-CD, dissolved in water, slowly added octacosanol ethanol to the aqueous solution of hydroxypropyl-β-CD after the start of ultrasonication, ultrasonicated for 30 minutes, vacuum freeze-dried, and grinded finely, after 60-100 mesh sieve to obtain octacosanol. After determination, the mass percentage of octacosanol in the clathrate is 2% to 40%. At the same time, a blank experiment is carried out to detect the dissolution rate of octacosanol in artificial gastric juice, distilled water, and phosphate according to the method described in the manual. The...
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