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Colchicine patch absorbing from skin for treating acute goute arthritis and the preparing method thereof

A technology of colchicine and acute gout, which is applied in the field of pharmaceutical preparations, can solve the problems of short onset time and low skin penetration rate, achieve short onset time, high content of active ingredients, improve blood drug concentration and biological The effect of utilization

Active Publication Date: 2007-10-31
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent 1165652 discloses a "colchicine patch", which is made of micron-sized raw materials, but this technology has the disadvantages of short onset time and low skin penetration rate

Method used

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  • Colchicine patch absorbing from skin for treating acute goute arthritis and the preparing method thereof
  • Colchicine patch absorbing from skin for treating acute goute arthritis and the preparing method thereof
  • Colchicine patch absorbing from skin for treating acute goute arthritis and the preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Transdermal enhancer Laurazone Azone 3kg

[0035] Pressure sensitive adhesive methyl acrylate 1000kg

[0036] Colchicine extracted from Arthia chinensis 0.5kg

[0037] β-cyclodextrin inclusion complex 2kg

[0038] Preparation method: According to the above formula, mix colchicine in water phase and oil phase vigorously at 80°C, emulsify under normal pressure, and perform micro-emulsification treatment for 15 minutes after high-shear stirring at 1500 rpm. Prepare a microemulsion dispersion and then clathrate it with β-cyclodextrin to make a dispersion, then add a transdermal absorption accelerator and pressure-sensitive adhesive to make a nano-powder, control the particle size of the colchicine drug component at 100nm, and enter the circle Type low-temperature drying coating machine, coating at 27 ℃, disinfection, shearing after coating, to make a patch, the loss rate is 20%, and the quality inspection pass rate is 80% according to the Chinese Pharmacopoeia patch stand...

Embodiment 2

[0040] Penetration enhancer sodium lauryl sulfate 5kg

[0041] Pressure sensitive adhesive polyisobutylene 1500kg

[0042] Colchicine extracted from Arthia chinensis 1kg

[0043] β-cyclodextrin inclusion complex 4kg

[0044]Preparation method: according to the above formula, mix colchicine in water phase and oil phase vigorously at 80°C, emulsify under normal pressure, and perform micro-emulsification treatment for 5 minutes after high-shear stirring at 1500 rpm. Prepare a microemulsion dispersion and then clathrate it with β-cyclodextrin to make a dispersion, then add a transdermal absorption accelerator and pressure-sensitive adhesive to make a nano-powder, control the particle size of the colchicine drug component at 150nm, and enter the circle Type low-temperature drying coating machine, coating at 27 ℃, disinfection, and shearing after coating, the patch was prepared with a loss rate of 15%, and a quality inspection pass rate of 85% according to the Chinese Pharmacopoei...

Embodiment 3

[0046] Penetration enhancer sodium lauryl sulfate 8kg

[0047] Pressure sensitive adhesive polyisobutylene 1200kg

[0048] Colchicine extracted from Arthia chinensis 1.5kg

[0049] β-cyclodextrin inclusion complex 5kg

[0050] Preparation method: According to the above formula, mix colchicine in water phase and oil phase vigorously at 80°C, emulsify under normal pressure, and perform micro-emulsification treatment for 10 minutes after high-shear stirring at 1500 rpm. Prepare a microemulsion dispersion and then clathrate it with β-cyclodextrin to make a dispersion, then add a transdermal absorption accelerator and a pressure-sensitive adhesive to make a nano-powder, and then make a nano-powder to control the composition of colchicine. The diameter is 200nm, enter the spiral low-temperature drying coating machine, coat at 27 ° C, sterilize, cut after coating, and make a patch, the loss rate is 10%, and the pass rate of quality inspection according to the Chinese Pharmacopoeia ...

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Abstract

The invention discloses an aqua-colchin percutaneous absorption plaster agent to treat acute gout and preparing method in medicinal preparation domain, which is characterized by the following: allocating 0. 5-1. 5 wt aqua-colchin, 3-8 wt transdermal accelerant and 1000-1500 wt pressure-sensitive adhesive; hypercritical-extracting bulb of edible tulip with carbon dioxide; getting the aqua-colchin; dispersing and refining the aqua-colchin to nanometer grade; controlling the nanometer grade grain size below 500nm. This invention can increase biological availability above 10 double, which can modify treating effect distinctively.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations characterized by sheet-like base materials, or transdermal drug delivery preparations. More specifically, it is prepared by using a carbon dioxide supercritical extraction method based on colchicine extracted from Arthia chinensis and adding a medicinal base A colchicine transdermal absorption patch for treating acute gout and a preparation method thereof. Background technique [0002] Transdermal drug delivery system or percutaneous absorption patch refers to a type of preparation that is applied through the skin, and the drug is absorbed through the skin into the blood circulation of the whole body and reaches an effective blood concentration to achieve disease treatment or prevention. The characteristic of the transdermal absorption patch is that the transdermal drug delivery system can avoid the first-pass effect of the liver and the inactivation of the drug in the gastroin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61K36/898A61K9/70A61P19/06A61M37/00
Inventor 李建民郝彬杨吉田高惠明
Owner TIANJIN ZHONGBAO PHARMACY
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