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Application of Gypensapogenin B in medicine for treating acute gout

A technology for acute gout and drugs, applied in the application field of Gypensapogenin B in the treatment of acute gout drugs, can solve problems such as neutropenia, aplastic anemia, etc., and achieve the effect of strong prevention and treatment activity and outstanding substantive characteristics

Active Publication Date: 2013-01-09
如东文园投资开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia

Method used

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  • Application of Gypensapogenin B in medicine for treating acute gout
  • Application of Gypensapogenin B in medicine for treating acute gout
  • Application of Gypensapogenin B in medicine for treating acute gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Preparation of Gypensapogenin B tablets of the compound involved in the present invention:

[0018] Take 20 grams of compound Gypensapogenin B, add 180 grams of conventional excipients for preparing tablets, mix them, and prepare 1,000 tablets with a conventional tablet press.

Embodiment 2

[0019] Example 2: Preparation of the compound Gypensapogenin B capsule of the present invention:

[0020] Take 20 grams of the compound Gypensapogenin B, add 180 grams of conventional auxiliary materials for preparing capsules, such as 180 grams of starch, mix well, and encapsulate to make 1000 tablets.

[0021] The following pharmacodynamic experiments will further illustrate its drug activity.

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PUM

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Abstract

The invention provides new application of Gypensapogenin B in medicine, namely application of Gypensapogenin B in preparing a medicine for treating acute gout. Experiment research results indicate that t Gypensapogenin B has the protective effect on acute gout models with human blood vessel endothelium cells damage cuased by urate, and restrains ICAM (intercellular adhesion molecule)-1 expression, so that Gypensapogenin B can be used for preparing the medicine for treating acute gout. The application of Gypensapogenin B in preparing the medicine for treating acute gout, which is provided by the invention, is disclosed for the first time. The skeleton type belongs to brand-new skeleton type, and the prevention activity of Gypensapogenin B to acute gout is extremely strong, so that no possibility for providing any prompt by other compounds exists. Gypensapogenin B has outstanding actual characteristics. Meanwhile, Gypensapogenin B has outstanding progress when being used for preventing and curing acute gout.

Description

Technical field [0001] The invention relates to a new use of Gypensapogenin B in medicine, and specifically relates to the application of Gypensapogenin B in preparing medicines for treating acute gout. Background technique [0002] Gout (gouty), also known as gouty arthritis (gouty arthritis), is a disease caused by the disorder of purine metabolism in the body. It is manifested as excessive uric acid in the blood, which easily causes urate (MSU) to precipitate crystals in joints and other tissues. The acute attack of gout is caused by the local infiltration of neutrophils and inflammatory reaction caused by MSU deposited in the joints. [0003] Western medicine uses three drugs in the acute attack of gout: colchicine, non-steroidal anti-inflammatory drugs and adrenal cortex hormones. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroidal anti-inflammato...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P19/06
Inventor 施桦王慧吴俊华
Owner 如东文园投资开发有限公司
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