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Method for preparing acrylic acid esters co-polymer membrane with anticoagulation function

A technology of acrylate and copolymer membranes, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve problems such as not resistant to high temperature disinfection, poor mechanical strength, etc.

Inactive Publication Date: 2007-10-17
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the polyacrylonitrile membrane has a strong removal ability for medium molecular weight substances, a high ultrafiltration rate, and excellent resistance to bacteria and organic solvents, but the membrane is brittle, poor in mechanical strength, and not resistant to high-temperature disinfection, which needs further improvement.

Method used

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  • Method for preparing acrylic acid esters co-polymer membrane with anticoagulation function
  • Method for preparing acrylic acid esters co-polymer membrane with anticoagulation function
  • Method for preparing acrylic acid esters co-polymer membrane with anticoagulation function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Add azobisisobutyronitrile, chloroform and N,N-dimethylformamide in turn to the container at room temperature, stir to make them fully mixed, transfer them into the polymerization reactor, and then add acryloyloxyethyl methyl ester and methyl acrylate, so that the molar ratio of methyl acrylate: acryloyloxyethyl methyl ester: azobisisobutyronitrile is 1: 0.50: 0.02, and the amount of total solvent is 8 times of the total monomer mass , The consumption of N,N-dimethylformamide is 50% of the total solvent mass. Continuously feed high-purity nitrogen for 10-40 minutes to remove oxygen, seal it, then place the polymerization reactor in a constant temperature water bath at 50°C, and oscillate (oscillation frequency 100-300rpm) for 24 hours. After the reaction was complete, the copolymer was precipitated with ether, filtered, and dried in vacuo.

[0028] Weigh a certain mass of copolymer in a container, use chloroform and N,N-dimethylformamide as solvents, adjust the concent...

Embodiment 2

[0030] Add dibenzoyl peroxide, chloroform and N,N-dimethylformamide in sequence at room temperature, stir to make them fully mixed, transfer them into the polymerization reactor, and then add acryloyl nonaoxyethyl formamide base ester and methyl methacrylate, so that methyl methacrylate: acryloyl nonaoxyethyl methyl ester: the material ratio of dibenzoyl peroxide is 1: 0.40: 0.015, and the consumption of total solvent is the total 9 times the mass of the monomer, and the amount of N,N-dimethylformamide is 40% of the total solvent mass. Continuously feed high-purity nitrogen for 10-40 minutes to remove oxygen, seal it, then heat the polymerization reactor to 60°C, stir (stirring frequency 100-300rpm) and react for 18 hours. After the reaction was complete, the copolymer was precipitated with ether, filtered, and dried in vacuo.

[0031] Weigh a certain mass of copolymer in a container, use chloroform and N,N-dimethylformamide as solvents, adjust the concentration of the copoly...

Embodiment 3

[0033]Add azobisisobutyronitrile, chloroform and ethanol in sequence in the container at room temperature, stir to make them fully mixed, transfer them to the polymerization reactor, and then add 2-methacryloyl dioxyethyl methyl ester and acrylic acid Methyl acrylate, so that methyl acrylate: 2-methacryloyl dioxyethyl methyl ester: azobisisobutyronitrile ratio of substances is 1: 0.30: 0.01, the amount of total solvent is the total monomer mass 10 times, the consumption of ethanol is 30% of total solvent mass. Continuously feed high-purity nitrogen for 10-40 minutes to remove oxygen, seal it tightly, then place the polymerization reactor in a constant temperature water bath at 70°C, and oscillate (oscillation frequency 100-300rpm) for 12 hours. After the reaction was complete, the copolymer was precipitated with ether, filtered, and dried in vacuo.

[0034] Weigh a certain mass of copolymer into a container, use chloroform and ethanol as solvents, adjust the concentration of ...

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Abstract

The invention relates to a preparation method of anticoagulant property acrylic ester copolymer membrane, and to the technology field of biology medical material preparation. The invention can prepare the acrylic ester copolymer in one-step by free radical polymerization, and then obtain the acrylic ester copolymer membrane by the evaporation of solution. The molecular weight, glass-transition temperature and mechanical strength of the acrylic ester copolymer membrane prepared in the method of the invention are controlled. The invention has anticoagulant property, and can be used in medical apparatus like hemodialysis. The invention provide a simple and high performance method for preparing anticoagulant property copolymer membrane.

Description

technical field [0001] The invention discloses a method for preparing an acrylic copolymer film with anticoagulant performance, which belongs to the technical field of preparation of biomedical materials. Background technique [0002] The key to preparing synthetic polymer membranes is to synthesize polymer substances with physiological compatibility, certain mechanical strength, and aging resistance. For example, the polyacrylonitrile membrane has a strong removal ability for medium molecular weight substances, a high ultrafiltration rate, and excellent resistance to bacteria and organic solvents. However, the membrane is brittle, has poor mechanical strength, and is not resistant to high-temperature disinfection, which needs further improvement. However, the present invention uses a physiologically compatible monomer as a functional monomer, and copolymerizes with the main monomer to obtain a copolymer, and then obtains a copolymer film by solvent evaporation. Contents o...

Claims

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Application Information

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IPC IPC(8): B01D71/40
Inventor 陈明清张晓冬倪忠斌熊万斌储鸿刘晓亚
Owner JIANGNAN UNIV
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