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Preparing method of high content full cis-beta-carotene preparation

A carotene, all-trans technology, applied in food preparation, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of precipitation of coarse particles, affecting the bioavailability of beta-carotene preparations, and destroying beta-carotene. Oil system and other problems, to achieve the effect of convenient operation, reducing the amount of cis isomers, and simple process

Active Publication Date: 2007-08-15
ZHEJIANG UNIV +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the desolvation process under reduced pressure is likely to destroy the stability of the β-carotene oil system, which will lead to the precipitation of coarse particles, which directly affects the bioavailability of β-carotene preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 100g β-carotene crystals, 20g monoglyceride stearate, 1g ethoxyquin, 1g dl-α-tocopherol, 1.2g p-hydroxyanisole, 0.5g ethyl gallate, 0.6g Hydroxytoluene and 0.7g 4-hexylresorcinol were dissolved in a mixed solvent of 1kg ethyl acetate and 4kg dichloromethane to make a solution. Then, it was added in the form of spray to 20L of ethanol under high-speed stirring to make β-carotene precipitate in the form of amorphous powder of <2μm. After filtration, the filter cake was added to water pre-dissolved with protective colloids and other auxiliary materials under high-speed shearing. After 0.5 hours of emulsification, the residual solvent was removed by heating, and finally spray-dried to obtain β-containing 93.4% all-trans isomer. Carotene preparations.

Embodiment 2

[0027] 100g β-carotene crystals, 20g Span-80, 0.3g ascorbyl palmitate, 0.1g mixed tocopherol, 0.1g tert-butyl hydroquinone, 0.1g tert-butyl hydroxyanisole, 0.3g gallbladder at 40℃ Octyl acid and 0.1 g stearyl gallate are dissolved in a mixed solvent of 2 kg n-hexane and 8 kg chloroform to make a solution. Then, it was added in the form of spray to 20L of isopropanol with high speed stirring to make β-carotene precipitate in the form of amorphous powder of <2μm. After filtration, the filter cake was added to the water pre-dissolved with protective colloids and other auxiliary materials under high-speed shearing. After 0.5 hours of emulsification, the residual solvent was removed by heating, and finally spray-dried to obtain β-containing 92.7% all-trans isomer. Carotene preparations.

Embodiment 3

[0031]100g β-carotene crystals, 15g Span-60, 1g ascorbyl palmitate, 0.5g butyl-4-methoxyphenol, 0.4g tert-butyl p-hydroxyanisole and 0.1g propyl gallate at 50℃ It is dissolved in a mixed solvent of 10kg n-hexane and 40kg petroleum ether to make a solution. Then, it was added into 100L isopropanol with high-speed stirring in the form of spray, so that β-carotene was precipitated in the form of an amorphous powder of <2μm. After filtration, the filter cake is added to water pre-dissolved with protective colloids and other auxiliary materials under high-speed shearing. After 0.5 hours of emulsification, the residual solvent is removed by heating, and finally spray-dried to obtain β-containing 89.2% all-trans isomer. Carotene preparations.

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PUM

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Abstract

The invention discloses a making method of high-full trans-beta-carotene agent, which comprises the following steps: setting the weight rate of beta-carontene, combined antioxidant and solvent with emulsifier at 1:0.01-0.1:50-500; dissolving the mass into water to form solution under 30-60 deg.c; adding into high-speed stirring alcohol or isopropanol at spraying pattern; making beta-carontene to evolve at amorphous starch powder with size less than 2um; filtering; adding filtering pie into auxiliary water protected by gel in advance; emulsifying; removing residual solvent; spraying; drying; obtaining the product with antioxidant A and B.

Description

Technical field [0001] The invention relates to a preparation method of a high all-trans β-carotene preparation. Background technique [0002] β-Carotene is a typical representative of the carotenoid family. It is not only an important source of vitamin A in the body, but also has important physiological functions for the human body. It can prevent, delay and treat certain diseases , It can also improve the body's immune function. [0003] The molecular formula of β-carotene is C 40 H 56 , The molecular weight is 536.88, its melting point is 184℃, and there are about 20 kinds of isomers. It is insoluble in water, methanol, ethanol, propylene glycol, glycerin, acid or alkali, slightly soluble in vegetable oils, moderately soluble in aliphatic and aromatic hydrocarbons, and easily soluble in chlorinated hydrocarbons; due to its unsaturated structure, It has strong antioxidant activity and ability to scavenge free radicals, so it has a certain physiological activity. However, it is ...

Claims

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Application Information

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IPC IPC(8): C07C403/24A23L1/275A61K31/015A23L5/44
Inventor 仇丹陈志荣李浩然石程尹红石立芳罗素红
Owner ZHEJIANG UNIV
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