Collagen modified poly(3-hydroxybutyrate-3-hydroxyvalerate) and its preparing method and application

Abstract

The invention discloses a modified collagen with 5-30% collagen, 50-90% poly-3-hydrobutanoate-3-hydrovalerate and 5-20% partial amidifying polyacrylamide and making method and application, which comprises the following steps: adopting PHBV as basic material to make PHBV film; irradiating through ultraviolet; grafting polyacrylamide; making amidified PHBV to do Hofmann decomposing reaction; producing amidifying PHBV; bonding PHBV and collagen with excellent compatibility and dynamics.

Description

technical field The invention relates to a modified biological material and its preparation technology, in particular to a collagen-modified poly(3-hydroxybutyrate-3-hydroxyvalerate) with good biocompatibility and mechanical properties and its Preparation. Background technique Poly(3-hydroxybutyrate-3-hydroxyvalerate) (PHBV) is a natural polyester polymer synthesized by microorganisms. Due to its good biocompatibility, degradability and piezoelectricity, it has broad application prospects in the fields of drug controlled release, suture, artificial skin, cartilage and bone tissue engineering. However, PHBV is poorly hydrophilic, and cells adhere weakly to its surface. For this reason, the introduction of functional groups on the surface of PHBV, thereby improving the hydrophilicity and biological activity of the surface of PHBV, and then improving the interaction between cells and materials has always been a hot spot in the functionalization of biomedical materials. Alth...

AI Technical Summary

Problems solved by technology

However, degradable polymer materials do not contain biological information, lack cell recognition signals, and are not conducive to cell-specific adhesion and activation of specific genes.

Images