Gene chip for detecting functional central nerve damage and its production method

Abstract

The invention relates to gene chip used for detecting functional central nervous damage diagnosis and the preparing method. said gene chip is equipped with oligonucleotide gene probe array, the oligonucleotide biomolecule of said probe array is the special biological gene factor playing improtant role in multiple central nervous system damage process simutaneously, relating to netural cell death and tissue necrosis, inflammation, irritated response, ion dysequilibrium inside cell, signal transmission, abnormal control of cell cycle, abnormal cell construction and nerve degeneration damage morbid physiology and molecular biology active gene, respectively. The gene chip can be used to check the conditioning way, expression level and change rule of biological factor relative to cerebral ischemia damage inside body in the beginning of clinic for high risk group of cerebral apoplexy, and to predict possibility of cerebral apoplexy; and used to conditioning way and change rule of special biological factor relative to nerve damage inside nerve cell after central nervous system damage, and relationship between cell death and disease occurancy, and provides checking criterion for cilinical treatment.

Description

technical field [0001] The invention belongs to the field of gene technology, and relates to a gene chip for the diagnosis and detection of functional central nervous system damage and a manufacturing method thereof, in particular to a specific detection and central nervous system damage (including brain damage caused by cerebral apoplexy or cerebrovascular accident) , traumatic brain injury and spinal cord injury) pathophysiological and molecular biological changes closely related to the oligonucleotide chip of the main neurotrauma shared genes. Background technique [0002] Central nervous system injury (including brain injury caused by cerebral apoplexy or cerebrovascular accident, traumatic brain injury and spinal cord injury) is a major disease that threatens human health. It results in severe disability and an unusually high mortality rate, as well as enormous medical rehabilitation costs. Every year in the United States, about 430,000 people suffer from cerebral apop...

AI Technical Summary

Problems solved by technology

However, traditional high-throughput gene expression profiling chips are costly and require a lot of data. Many gene expression data are unnecessary or useless data for researchers.