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Preparation for treating angiocardiopathy and its preparation method

A cardiovascular and preparation technology, applied in the field of preparations for the treatment of cardiovascular diseases and their preparation, can solve the problems of complex preparation manufacturing process, slow disintegration of the original tablet, difficult drug stability and the like, and achieves improved bioavailability, Conducive to labor protection and environmental protection, good drug stability

Inactive Publication Date: 2007-07-18
SHANDONG TAITIAN NEW MEDICINE DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing Tongmailing tablets are film-coated tablets or sugar-coated tablets. The main component is alcohol or water extract, which is highly viscous. It needs to add a large number of auxiliary materials such as starch and lubricants to make granules, compressed tablets, and film-coated or sugar-coated tablets. Preparation process is more complex
In particular, the original process contains balsamic volatile oil, which brings difficulty to tablet compression and poor drug stability, and the original tablet has defects such as slow disintegration speed, long dissolution time limit, low dissolution rate, poor absorption, and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Tongmailing dripping pill of the present invention adopts following prescription (below the same):

[0051] Danshen 250, safflower 62.5, turmeric 125, rehmannia 125

[0052] Jiangxiang 62.5 Chuanxiong 62.5 Frankincense (made) 31.5 myrrh (made) 31.56

[0053] In the above composition, each part represents a part by weight, and the weight is calculated based on the crude drug, and the unit is gram.

[0054] Prepared using the following steps:

[0055] Step 1 Extraction and preparation of raw materials

[0056] 1) Percolation method (Appendix IO of Chinese Pharmacopoeia 2005 edition) under safflower extract and extract item with 70% ethanol

[0057] As a solvent, infiltrate after soaking for 24 hours, collect 8 times the volume of the medicinal material, concentrate until it has no alcohol smell, and set aside;

[0058] 2) Extract volatile oil from Dalbergia basilica, medicinal dregs and aqueous solution with Salvia miltiorrhiza, Curcuma, Rehmannia glutinosa, Chuanxion...

Embodiment 2

[0068] Step 1 Extraction and preparation of raw materials

[0069] 1) The infiltration method (Appendix IO of Chinese Pharmacopoeia 2005 edition) under safflower extract and extract item, with 70% ethanol

[0070] As a solvent, infiltrate after soaking for 24 hours, collect 10 times the volume of the medicinal material, concentrate until it has no alcohol smell, and set aside;

[0071] 2) Extract volatile oil from Dalbergia basilica, decoct medicinal dregs and aqueous solution with salvia miltiorrhiza, turmeric, rehmannia glutinosa, and chuanxiong for three times.

[0072] 2 hours, 1.5 hours for the second time, 1 hour for the third time, combine the decoction, filter, and set aside the filtrate;

[0073] 3) The above solutions were combined, concentrated under reduced pressure at a temperature of 80°C to form a thick paste, dried under reduced pressure, and pulverized into fine powder.

[0074] Mix with the volatile oil obtained above, frankincense (made) and myrrh (made) t...

Embodiment 3

[0080] Step 1 Extraction and preparation of raw materials

[0081] 1) Frankincense (made) and myrrh (made) are crushed into coarse powder and safflower extract and the method of infiltrating deer under the extract (Chinese

[0082] Chinese Pharmacopoeia 2005 edition appendix 10), make solvent with 70% ethanol, carry out infiltration after soaking 24 hours, collect

[0083] Liquid, concentrated to no alcohol smell, set aside;

[0084] 2) Extract volatile oil from Dalbergia basilica, decoct medicinal dregs and aqueous solution with salvia miltiorrhiza, turmeric, rehmannia glutinosa, and chuanxiong for three times.

[0085] 2 hours, 1.5 hours for the second time, 1 hour for the third time, combine the decoction, filter, and set aside the filtrate;

[0086] 3) The above solutions were combined, concentrated under reduced pressure at a temperature of 80°C to form a thick paste, dried under reduced pressure, and pulverized into fine powder.

[0087] Mix with the volatile oil obta...

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Abstract

A Chinese medicine 'Tongmailing dripping pill' for treating cardiovasular disease is prepared from 8 Chinese-medicinal materials including red sage root, safflower, rehmannia root, Chuan-xiong rhizome, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a preparation for treating cardiovascular diseases and a preparation method thereof. Tongmailing dripping pills are a secondary development of Tongmailing Tablets, a Chinese patent medicine used for gelatin pain and myocardial infarction, and belong to the improvement of Chinese medicine compound preparations. technology. Background technique [0002] Tongmailing tablet is a Chinese patent medicine for treating cardiovascular diseases, which is clinically used for the treatment of chest pain and heart pain. Its functions and indications are promoting blood circulation and removing blood stasis, dredging channels and relieving pain; it is used for atherosclerosis and myocardial infarction. [0003] The main composition of Tongmailing Tablets is 8 traditional Chinese medicines including safflower, jiangxiang, frankincense, myrrh, salvia, rehmannia, chuanxiong and turmeric. The pathogenesis of coronary heart disease is the forma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/20A61K47/12A61K47/34A61K47/42A61J3/06A61P9/10A61K47/10
Inventor 邢来田窦春水许双庆汪海洋
Owner SHANDONG TAITIAN NEW MEDICINE DEV
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