Application of zedoary root cyclic diolefine in preparing medicament for treating tumour disease
A kind of technology of zedoary cyclodiene and tumor, which is applied in the direction of antineoplastic drugs, drug combinations, antiviral agents, etc.
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Embodiment 1
[0119] The preparation of embodiment 1 turmeric cyclodiene
[0120] Take 1 kg of dried rhizomes of Curcuma rhizome, cut into pieces and pulverize, and distill through a steam distillation device to obtain a total of 185 g of oil-water mixture, extract with ether and petroleum ether, separate the oil layer, discard the water layer, and concentrate to obtain 16.5 g of Zedoary volatile oil, Use a silica gel column to separate, elute with petroleum ether, collect in 100ml per bottle, combine 26 to 42 components, remove the solvent to obtain 8.6g of yellow crystals, then separate on a silica gel column, elute with petroleum ether, combine 16 to 30ml in each bottle ~28 components, the solvent was removed to obtain 3.7g of white crystals, the purity of the sample reached 99.7% by HPLC analysis, and the positive ion detection of high-resolution mass spectrometry showed that the quasi-molecular ion peak of the sample [M+H] + It is 217.1583, and its molecular weight is deduced to be 216...
Embodiment 2
[0121] Example 2 Pengzezhu Cyclodiene Injection
[0122] Prescription: 1g of zedoary cyclodiene, add vegetable oil for injection (tea oil, soybean oil, etc.) to 1000ml
[0123] Preparation process::Take vegetable oil for injection, dry heat sterilization at 150°C for 1 hour, let cool to 50°C, take out part of the oil and add turmeric cyclodiene, stir to dissolve, and finally add solvent to the full amount. Filter it with a dry No. 6 vertical fusing glass funnel, fill it in a 1ml dry sterilized ampoule, and sterilize it with circulating steam at 100°C for 30 minutes to make an injection solution containing 1 mg of phagozoa cyclodiene in 1 ml of each ampoule.
[0124] Usage and dosage: Intramuscular injection, 0.5-1ml each time.
Embodiment 3
[0125] Embodiment 3 Peng Curcuma Cyclodiene Emulsion Injection
[0126] Prescription: Pengcurcumadiene 1g
[0127] soybean oil 15g
[0128] Phospholipids 7.5g
[0129] Oleic acid 1.47g
[0130] Appropriate amount of water for injection
[0131]
[0132] Total 100ml
[0133] Preparation process: Dissolve phospholipids in soybean oil first, add the main drug fencura cyclodiene, stir to dissolve, then add oleic acid and stir evenly, filter through a microporous membrane with a pore size of 0.22 μm for later use, add water for injection to the prescription amount, the homogenizer is made into colostrum, and the homogenizer is used to make it reach the particle size of the emulsion. Sterile filtration was carried out through a microporous filter membrane with a pore size of 0.22 μm, and finally it was filled in a dry sterile ampoule of 1 ml. Make each ampule 1ml containing the emulsion injection of 10mg of turmeric cyclodiene.
[0134] Usage ...
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