Bio-compatible monodisperse nano polymer carrier and its preparation and medicine-carrying method

Abstract

Biocompatible monodisperse nanopolymer carrier and methods for its preparation and drug loading. First, an amphiphilic block copolymer with a small molecular weight distribution index was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization, in which the hydrophilic segment was methacryloyloxyethylphosphorylcholine (MPC ), and the hydrophobic segment is n-butyl methacrylate (BMA). Then, the above-mentioned amphiphilic block copolymer is used to prepare nanometer polymer micelles by a solvent evaporation method, and drugs are encapsulated in the micelles by physical action to obtain a monodisperse nanometer polymer drug-carrying system with good biocompatibility.

Description

technical field [0001] The invention relates to a biocompatible monodisperse nanometer polymer drug-carrying system and a preparation method thereof, belonging to the technical field of pharmaceutical engineering. Background technique [0002] Many antineoplastic drugs (such as paclitaxel, doxorubicin, methotrexate, etc.) have very low solubility in water, and they also have strong toxic and side effects. Therefore, the direct use of such antineoplastic drugs has very low efficacy. and cause greater harm to the human body. In order to solubilize hydrophobic drugs and achieve drug sustained release, researchers have extensively studied many drug delivery systems, such as liposomes, microspheres, surfactant micelles, etc., but these systems still have many shortcomings, such as: lipid Surfactants and microspheres have large particle sizes and are easily phagocytosed by the human reticuloendothelial system (RES); surfactant micelles have a high critical micelle concentration (...

AI Technical Summary

Problems solved by technology

[0002] Many antineoplastic drugs (such as paclitaxel, doxorubicin, methotrexate, etc.) have very low solubility in water, and they also have strong toxic and side effects. Therefore, the direct use of such antineoplastic drugs has very low efficacy. and cause greater harm to the human body

In order to solubilize hydrophobic drugs and achieve drug sustained release, researchers have extensively studied many drug delivery systems, such as liposomes, microspheres, surfactant micelles, etc., but these systems still have many shortcomings, such as: lipid Surfactants and microspheres have large particle sizes and are easily phagocytosed by the human reticuloendothelial system (RES); surfactant micelles have a high critical micelle concentration (CMC) and lack good anti-dilution properties, etc.

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